In vitro evaluation of the use of diluted sodium hypochlorite (bleach) against Staphylococcus pseudintermedius,Pseudomonas aeruginosa and Malassezia pachydermatis

Recommendations for approaches to meticillin‐resistant staphylococcal infections of small animals: diagnosis, therapeutic considerations and preventative measures.

“…Despite the absence of reports on clinical treatment failure of topical anti‐staphylococcal treatment so far, monitoring of MICs, clinical efficacy and further evaluation of topical treatment alternatives such as hypochlorite (bleach), manuka honey and of synergistic combinations is warranted . For MRS infections involving biofilm‐producing strains (for example, around lip folds or implants), additional measures to improve efficacy of topical antibacterial agents may be needed.…”

Diluted sodium hypochlorite (bleach) in dogs: antiseptic efficacy, local tolerability and in vitro effect on skin barrier function and inflammation

“…Limited data are available on the microbiological efficacy of dilute bleach on methicillin‐susceptible (MSSP) and ‐resistant S. pseudintermedius (MRSP) . One study recommended a 15 min exposure of household bleach dilution at 0.19% for killing MRSP isolates .…”

“…We elected to test this higher hypochlorite concentration directly on the normal skin of atopic dogs outside an active AD flare, because it did not induce significant ceramide changes in the CPEK‐derived epidermal construct and we wished to better approximate the concentration proposed in a review on the therapeutic approach to canine pyoderma . Furthermore, a stronger in vitro antimicrobial effectiveness of diluted sodium hypochlorite against common canine pathogenic micro‐organisms affecting the skin has been reported at higher concentrations . Sterile water was used as a negative control.…”

“…8 Furthermore, a stronger in vitro antimicrobial effectiveness of diluted sodium hypochlorite against common canine pathogenic micro-organisms affecting the skin has been reported at higher concentrations. 9,10 Sterile water was used as a negative control. All testing products were freshly prepared for each application.…”

A pilot study comparingin vitroefficacy of topical preparations against veterinary pathogens

“…Although the investigation of antimicrobial agents is ongoing, evidence of broad spectrum activity and efficacy in the presence of antimicrobial resistance of many antiseptics in veterinary use is still lacking. Previous in vitro reports demonstrated the efficacy of chlorhexidine and sodium hypochlorite (bleach, NaOCl) against a range of microorganisms. Studies investigating the combination of chlorhexidine and climbazole, hypochlorous acid (HOCl), manuka honey (MH), lime sulfur (LS) and alcohols are lacking.…”