<i>In vitro</i> evaluation of the ability of platelet‐rich plasma to seal an iatrogenic fetal membrane defect

Lewi, Liesbeth; Liekens, Daisy; Heyns, Liesbeth; Poliard, E; Beutels, Elke; Deprest, Jan; Hoylaerts, Marc

doi:10.1002/pd.2249

Cited by 13 publications

(8 citation statements)

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“…The ability of a collagen plug soaked in fibrinogen concentrate to seal an iatrogenic fetal membrane defect was tested in an ex vivo iPPROM model . In brief, this consists of a fetal membrane clamped over a standardized (30 mm × 30 mm) opening in a container, with the amnion facing the inside of the container.…”

Section: Methodsmentioning

confidence: 99%

In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma

et al. 2013

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Section: Methodsmentioning

confidence: 99%

In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma

et al. 2013

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“…In an in-vitro study, PRP was used to assess its ability to seal an iatrogenic fetal membrane defect [30]. If during pregnancy these membrane defects do not seal spontaneously, it is most likely that fluid leakage through the vagina may occur, resulting in infections and pregnancy loss.…”

Section: Gynecologymentioning

confidence: 99%

Is the Use of Autologous Platelet-Rich Plasma Gels in Gynecologic, Cardiac, and General, Reconstructive Surgery Beneficial?

Everts¹,

Hoogbergen²,

A.Weber³

et al. 2012

CPB

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Tissue repair at wound sites begins with clot formation, and subsequently platelet degranulation with the release of platelet growth factors, which are necessary and well-regulated processes to achieve wound healing. Platelet-derived growth factors are biologically active substances that enhance tissue repair mechanisms, such as chemotaxis, cell proliferation, angiogenesis, extracellular matrix deposition, and remodeling. This review describes the biological background and results on the topical use of autologous platelet-rich plasma and platelet gel in gynecologic, cardiac, and general surgical procedures, including chronic wound management and soft-tissue injuries.

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“…Laser therapy carries small risks of preterm prelabour ruptured membranes (5%) and intra‐amniotic haemorrhage (<1%). Patching of membranes with platelets and cryoprecipitate 31 has been used following fetoscopy and, more recently, patching with platelet‐rich plasma in vitro ; 32 these techniques may reduce the morbidity and mortality associated with preterm prelabour rupture of the membranes in the future.…”

Section: Placental Diseasementioning

confidence: 99%

Advances in fetal therapy

Morris

Chan

Kilby

2010

The Obstetric & Gynaecologis

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Key content Fetal medicine is a rapidly developing subspecialty. The mainstay of treatment for fetal alloimmune thrombocytopenia remains maternal immunoglobulin therapy. Stem cell transplantation and gene therapy have advanced over the last decade but must still be considered experimental. Laser coagulation is the best treatment for all stages of twin‐to‐twin transfusion syndrome presenting before 26 weeks of gestation. Fetoscopic endoluminal tracheal occlusion appears to improve prognosis in severe congenital diaphragmatic hernia. Learning objectives To gain an overview of the recent developments in fetal therapy. To understand the benefits and risks of different methods of fetal therapy. To appreciate the importance of high‐quality research in fetal medicine. Ethical issues With the option of fetal therapy, the value and implications of prenatal diagnosis have to be reviewed. The acceptability of fetal therapy to parents and to society should be investigated. The consideration of the mother and fetus as individual people presents an inherent difficulty in implementing randomised controlled trials in fetal medicine. Please cite this article as: Morris RK, Chan BC, Kilby MD. Advances in fetal therapy. The Obstetrician & Gynaecologist 2010;12:94–102.

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In vitro evaluation of the ability of platelet‐rich plasma to seal an iatrogenic fetal membrane defect

Abstract: Our in vitro experiments suggest that PRP plugs may provide a long-lasting, waterproof sealing of fetal membrane defects and stimulate fetal membrane repair.

Cited by 13 publications

References 18 publications

In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma

In vitro sealing of iatrogenic fetal membrane defects by a collagen plug imbued with fibrinogen and plasma

Is the Use of Autologous Platelet-Rich Plasma Gels in Gynecologic, Cardiac, and General, Reconstructive Surgery Beneficial?

Advances in fetal therapy

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