In vitro evaluation of anti-hepatoma activity of brevilin A: involvement of Stat3/Snail and Wnt/β-catenin pathways

Abstract

Brevilin A, a natural sesquiterpene lactone extracted from Centipeda minima, has been found to exhibit anti-tumor effect.

Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway

“…STAT3 can access the active promoter region of H19 to upregulate H19 expression [ 50 ]. Brevilin A functions as an inhibitor of Stat3 pathway [ 51 ]. Therefore, we guessed whether Brevilin A has a role in H19 expression.…”

Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway

“…At the same concentration (100 µM), brevilin A had a better toxic effect than cisplatin, known for curing various types of cancer (Figure 6D). Previous studies have reported that brevilin A shows anticancer effects against a range of cancer cells, including a human lung adenocarcinoma cell line (A549), human breast cancer cell lines (MCF-7 and MDA-MB-231), a human colon cancer cell line (SW480), human liver cancer cell lines (HepG2 and SMMC-7221), and human melanoma cell lines (A375 and A2058), with respective 24-h IC50 values of 10, 12, 7, 13, 13, 17, 1.98, and 2.71 µM [5][6][7].…”

“…For example, arnicolide D isolated from CMX has been demonstrated to have anticancer effects against human nasopharyngeal carcinoma cells [4]. Previous studies have also reported that brevilin A, of which CMX is an abundant source, shows anticancer effects on a range of different cancer cell lines, including those of lung, breast, liver, and colon cancers and melanoma [5][6][7]. Brevilin A is a natural sesquiterpene lactone that has been established to have a range of pharmacological effects, including anti-influenza viral [8], antiprotozoal [9], and anti-inflammatory [10] activities.…”

Brevilin A exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling in vitro

“…Studies have shown that sesquiterpene lactones have anti-inflammatory, anti-oxidative and anti-cancer properties [ 13 , 14 ]. Brevilin A, a sesquiterpene lactone in Centipedae Herba, has been proved to possess anti-fibrotic [ 15 ], anti-virus [ 16 ] and anti-cancer effects, including anti-breast cancer [ 17 ], anti-lung cancer [ 18 , 19 ], anti-hepatoma [ 20 ], anti-glioblastoma [ 21 ], anti-nasopharyngeal carcinoma, anti-melanoma [ 22 ] and anti-gastric cancer [ 23 ] effects, which stimulates researchers’ interest in developing brevilin A or its derivatives as novel anti-cancer drug(s) [ 24 ]. In the future, whether it can be developed into a drug for clinical treatment of tumors needs further study.…”