In vitro evaluation of antagonism, modulation of cytokines and extracellular matrix proteins by Bifidobacterium strains

Abstract

The skin is the first line of defence against invasive micro-organisms, and its local microbiota provides additional protective functions based on antagonism against pathogenic micro-organisms and immunomodulation. Based on in vitro assays using Bifidobacterium spp. we demonstrated the antagonistic potential, as well as capacity in stimulating the production of cytokines and proteins of the extracellular matrix that these bacteria may exert on skin cells. This positive influence suggests the use of a consortium of these bifidobacteria in a topical product for dermatological treatments.

Immunomodulatory Effects of Bifidobacterium spp. and Use of Bifidobacterium breve and Bifidobacterium longum on Acute Diarrhea in Children

“…As a result, recent research efforts have tended to focus on the immunomodulatory effects of postbiotics. Furthermore, the use of non-viable microbial cell extracts to treat wounds has shown that inactivated postbiotic bifidobacteria are more effective than viable forms in some subjects [ 24 ].…”

Antimicrobial and Immunomodulatory Effects of Bifidobacterium Strains: A Review

“…Furthermore, the levels of IL-8 decreased in all inactivated bacteria and live B. longum and B. pseudolongum , and the decrease was greater in the inactivated bacteria. In the case of IL-6, an anti-inflammatory cytokine, all tested inactivated and live bifidobacteria reduced its levels, with the exception of live B. pseudolongum 119 1A [ 33 ].…”