<i>In Vitro</i>
            Evaluation of A Novel Nanostructured Ti-36Nb-6Ta Alloy for Orthopedic Applications

Voltrova, Barbora; Jarolimova, Petra; Hybášek, Vojtěch; Blahnová, Veronika Hefka; Šepitka, Josef; Sovková, Věra; Matějka, Roman; Daniel, Matěj; Fojt, Jaroslav; Filová, Eva

doi:10.2217/nnm-2020-0123

Cited by 7 publications

(3 citation statements)

References 74 publications

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“…The Ti-36Nb-6Ta alloy was chosen for two reasons. The first is the known properties and response of the cellular systems, even in the nanotopographically enhanced surface variant [36]. The second is the high content of niobium oxides in the layer, and niobium was chosen based on the possible structural change in the target pH range (Figure 7), which can be expected to affect the electrochemical response.…”

Section: Discussionmentioning

confidence: 99%

pH Sensing for Early Detection of Septic Inflammation Based on Intrinsic Titanium β-Alloy Nanotubular Oxides

Fojt,

Šťovíček,

Jírů

et al. 2024

Metals

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Orthopaedic surgeries like total hip and knee arthroplasty play a crucial role in restoring joint function for individuals with osteoarthritis. Deep bacterial infections are one of the most serious complications for orthopaedic implants. An infectious complication of an orthopaedic implant requires long-term and demanding treatment, often with repeated surgical procedures, and can lead to serious consequences such as implant failure, sepsis, and even death. Early detection of complications is of key importance for efficient therapy. The objective of this work is to investigate the possibilities of the nanotubular TiNbTa oxide for pH change sensing. Different surface treatments which lead to different surface natures were tested. For experiments, the inflammation was simulated by pH changes in the physiological solution. The response of the surface was monitored via the electrode potential changes. The results show that the nanotubular surface prepared on the TiNbTa alloy is a good possible candidate for pH sensing devices.

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Section: Discussionmentioning

confidence: 99%

pH Sensing for Early Detection of Septic Inflammation Based on Intrinsic Titanium β-Alloy Nanotubular Oxides

Fojt,

Šťovíček,

Jírů

et al. 2024

Metals

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“…More than 150 proteins, such as vinculin, talin and kindlin, have been identified in protein complexes called focal adhesions, which link integrin to the actin cytoskeleton and thus promote cell adhesion, migration and proliferation [ 55 , 56 ]. Vinculin, a membrane–cytoskeletal focal adhesion protein, serves to anchor actin filaments to the membrane; therefore, it plays an important role in cell spreading, lamellipodia formation and cell shape control [ 57 ].…”

Section: Osteogenic Differentiation and Its Testingmentioning

confidence: 99%

“…The immunohistochemical staining is also used to visualize specific proteins structures, such as Col1 or OCN [ 55 , 64 ].…”

Section: Osteogenic Differentiation and Its Testingmentioning

confidence: 99%

Human cells with osteogenic potential in bone tissue research

et al. 2023

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Bone regeneration after injury or after surgical bone removal due to disease is a serious medical challenge. A variety of materials are being tested to replace a missing bone or tooth. Regeneration requires cells capable of proliferation and differentiation in bone tissue. Although there are many possible human cell types available for use as a model for each phase of this process, no cell type is ideal for each phase. Osteosarcoma cells are preferred for initial adhesion assays due to their easy cultivation and fast proliferation, but they are not suitable for subsequent differentiation testing due to their cancer origin and genetic differences from normal bone tissue. Mesenchymal stem cells are more suitable for biocompatibility testing, because they mimic natural conditions in healthy bone, but they proliferate more slowly, soon undergo senescence, and some subpopulations may exhibit weak osteodifferentiation. Primary human osteoblasts provide relevant results in evaluating the effect of biomaterials on cellular activity; however, their resources are limited for the same reasons, like for mesenchymal stem cells. This review article provides an overview of cell models for biocompatibility testing of materials used in bone tissue research.

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Electrochemical impedance response of the nanostructured Ti–6Al–4V surface in the presence of S. aureus and E. coli

2023

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Implant infections associated with biofilm are a significant problem in current healthcare. Early detection of the development of bacterial infection would allow the deployment of antibiotic treatment to suppress complications. Biofilm detection can be based on the changes in the electrochemical response of a metal oxide sensor. The nanostructured surface of titanium alloys provides a large active/geometric surface area ratio and may respond to the presence of bacteria by changing its behaviour. In this work, the changes in impedance response of nanostructured Ti–6Al–4V alloy surface in the presence of E. coli and S. aureus were studied. The nanostructures were prepared by anodic oxidation in a fluoride ions-containing environment. The change in impedance spectra and open circuit potential of the prepared surfaces was monitored for 48 h. Furthermore, a series of measurements in model systems were carried out to help identify the processes leading to the change in the electrochemical behaviour of the surface. The measurements showed significant changes in the surface impedance response over a wide range of frequencies and for both bacterial strains. Based on the results, the implantable sensor based on the nanotubular titanium oxide seems to be a possible and simple way how to detect bacterial infection. Graphical Abstract

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In Vitro Evaluation of A Novel Nanostructured Ti-36Nb-6Ta Alloy for Orthopedic Applications

Cited by 7 publications

References 74 publications

pH Sensing for Early Detection of Septic Inflammation Based on Intrinsic Titanium β-Alloy Nanotubular Oxides

pH Sensing for Early Detection of Septic Inflammation Based on Intrinsic Titanium β-Alloy Nanotubular Oxides

Human cells with osteogenic potential in bone tissue research

Electrochemical impedance response of the nanostructured Ti–6Al–4V surface in the presence of S. aureus and E. coli

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