<i>In vitro</i> Efficacy of Ureteral Catheters Impregnated with Ciprofloxacin, N-acetylcysteine and their Combinations on Microbial Adherence

El-Rehewy, Mostafa S.; El-Feky, Mohamed A; Hassan, Mona A.; Abolella, Hassan A; Abolyosr, Ahmad; El-Baky, Rehab Mahmoud Abd; Gad, Gamal Fadl Mahmoud

doi:10.4137/cmu.s3367

Cited by 11 publications

(12 citation statements)

References 27 publications

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“…Many studies reported that NAC increase the therapeutic activity of antibiotics. El-Rehewy et al, [36] and El-Feky et al [37] investigated the effect of NAC (2 and 4mg/mL) in combination with ciprofloxacin (MIC and 2 × MIC) against biofilm cells of several bacteria including S. aureus, S. epidermidis, E. coli. and others.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

Mohsen¹,

Gomaa²,

Mohammed³

et al. 2015

AJEID

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Ureteral catheters are indispensable devices used in the management of ureteral obstruction. Although the stent is essential for treatment, it also has complications, which are encrustation, stone formation and biofilm formation. Biofilm infections result in a complication in the course of treatment, increasing the length of patients stay in hospital and overall cost. Catheter-associated infections are difficult to be treated with antibiotics and there is a need to change catheters due to the formation of biofilm on their surfaces. In this study, In this study, we examine the effect of some of prescribed drugs as NSAIDs and N-acetylcysteine on the adherence of S. aureus, K. pneumoniae, P. aeruginosa and Proteus mirabilis on the surface of catheters, and their effects on the preformed mature biofims. Also, we determine their antibacterial activity. The results showed that the tested agents had good antibacterial activity, a significant effect on the inhibition of adherence of the tested strains to plastic surfaces and a high disruptive effect on mature biofilms. In conclusion, the tested drugs can be used in the treatment of catheterassociated infections.

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Section: Discussionmentioning

confidence: 99%

Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

Mohsen¹,

Gomaa²,

Mohammed³

et al. 2015

AJEID

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“…Evaluating the qualitative antibacterial activity of coated IVC materials 23 Antibacterial activity of all the coated catheter samples was qualitatively evaluated. Coated catheters were sterilized and placed over Mueller-Hinton agar (MHA) surface which was seeded with test organisms.…”

Section: Methodsmentioning

confidence: 99%

Antibacterial Drug and Carrier Loaded Catheters to Retard Device Associated Bacterial Infections

Remya¹,

Vijayachitra²

2018

Int. J. Res. Ayurveda Pharm.

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In this research work, the intravascular catheter surface was modified with antibacterial coatings for the prevention of bacterial biofilm formation. Surface was coated with two synergistic drug combinations (Moxifloxacin-Ornidazole) grafted with a biodegradable carrier (DL-lactic acid). The carrier acts like bridging agent between catheter surface and drugs; it also allows the drug mixtures to get released from the surface very stable. So that the concentrations of the drugs would get released at sustained rate with an initial drug burst concentrations. To evaluate the biofilm producing capability of the test organisms, Microtitre plate assay was employed. The qualitative antibacterial activity of the coated catheters was evaluated against the test organisms (Escherichia coli, Acinetobacter baumannii, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans). Good and evident inhibitory zones around the coated catheters were found potential in preventing the growth of biofilm producers. In conclusion, the obtained results revealed that the catheter surface modified with antibacterial coatings have prevented catheter-associated biofilm producing organisms.

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“…AMP-coated wound dressing materials were subjected to evaluate the qualitative antibacterial activity against the test organisms individually (El-Rehewy et al, 2009). The standard disk diffusion method was used in the research to evaluate the antibacterial activity.…”

Section: Qualitative Antibacterial Activity Of Amps + Pva-coated Matementioning

confidence: 99%

Extraction and antibacterial evaluation of marine AMPs against diabetic wound pathogens

Tom¹,

Uma²,

Sivagurunathan³

et al. 2020

J Appl Pharm Sci

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In vitro Efficacy of Ureteral Catheters Impregnated with Ciprofloxacin, N-acetylcysteine and their Combinations on Microbial Adherence

Cited by 11 publications

References 27 publications

Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

Antibacterial Drug and Carrier Loaded Catheters to Retard Device Associated Bacterial Infections

Extraction and antibacterial evaluation of marine AMPs against diabetic wound pathogens

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