Antibacterial Drug and Carrier Loaded Catheters to Retard Device Associated Bacterial Infections

Abstract

In this research work, the intravascular catheter surface was modified with antibacterial coatings for the prevention of bacterial biofilm formation. Surface was coated with two synergistic drug combinations (Moxifloxacin-Ornidazole) grafted with a biodegradable carrier (DL-lactic acid). The carrier acts like bridging agent between catheter surface and drugs; it also allows the drug mixtures to get released from the surface very stable. So that the concentrations of the drugs would get released at sustained rate with an initial drug burst concentrations. To evaluate the biofilm producing capability of the test organisms, Microtitre plate assay was employed. The qualitative antibacterial activity of the coated catheters was evaluated against the test organisms (Escherichia coli, Acinetobacter baumannii, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans). Good and evident inhibitory zones around the coated catheters were found potential in preventing the growth of biofilm producers. In conclusion, the obtained results revealed that the catheter surface modified with antibacterial coatings have prevented catheter-associated biofilm producing organisms.