<i>In vitro</i> effect of calcium dobesilate on oxidative/inflammatory stress in human varicose veins

Alda, O.; Valero, Marta Sofía; Pereboom, Désirée; Serrano, Pedro; Azcona, J.; Garay, Ricardo P.

doi:10.1258/phleb.2010.010052

Cited by 21 publications

(11 citation statements)

References 21 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The obtained results showed that the drug significantly improved antioxidant defense. 29 Calcium dobesilate is a drug strengthening blood vessels, commonly used in patients with CVI and thrombotic disease of the lower limbs. 30 The surgery technique used in the stripping of the GSV differs from the harvesting of the GSV used in the CABG surgery.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative mechanism in the course of varicose veins

et al. 2017

View full text Add to dashboard Cite

Objective Our objective was to evaluate the state of oxidative stress in the great saphenous varicose vein wall and blood of varicose vein patients taken from the antecubital vein. Methods The superoxide dismutase, reduced glutathione (GSH) and total antioxidant status were measured with commercially available colorimetric kits in erythrocytes, plasma and varicose vein wall of 65 patients (second degree of clinical state classification, etiology, anatomy and pathophysiology) aged 22-70 (49 women, 16 men) in comparison to normal great saphenous vein walls collected from 10 patients who underwent coronary artery bypass graft and blood collected from 20 healthy individuals. Results A statistically significant decrease (p < 0.001) in superoxide dismutase activity in erythrocytes and the increase (p < 0.05) in superoxide dismutase activity in varicose vein has been observed. There have been no significant changes in the concentration of GSH in plasma and in varicose vein. The decreased concentration of total antioxidant status in plasma (p < 0.001) and in varicose vein wall (p < 0.05) in comparison to the control has been noticed. Conclusion The varicose vein patients are affected by oxidative stress. Our results indicate impaired antioxidant defense mechanism in the blood of varicose vein patients. In contrast to the blood, an increased process of antioxidant defense in the varicose vein wall was noticed.

show abstract

Section: Discussionmentioning

confidence: 99%

Antioxidative mechanism in the course of varicose veins

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In this sense, the fish oil emulsion, rich in Ω-3 polyunsaturated fatty acids, has anti-inflammatory and antioxidant in vitro properties, with the capability to inhibit the production of pro-inflammatory growth factors and cytokines [ 22 ]. Table 1 summarizes the main in vitro studies on antioxidants and their results as possible therapeutic agents for DR treatment [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ].…”

Section: In Vitro Experimentsmentioning

confidence: 99%

Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials

et al. 2020

View full text Add to dashboard Cite

Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular endothelial growth factors or corticosteroids. Nonetheless, these techniques have not been demonstrated to completely stop the evolution of this disorder. The pathophysiology of DR is not fully known, but there is more and more evidence indicating that oxidative stress is an important mechanism in the progression of DR. In this sense, antioxidants have been suggested as a possible therapy to reduce the complications of DR. In this review we aim to assemble updated information in relation to in vitro experiments, animal studies and clinical trials dealing with the effect of the antioxidants on DR.

show abstract

“…30 In our study, patients in the calcium dobesilate group also showed a statistically significant improvement in the CIVIQ sub score “pain or discomfort in ankles or legs during the past four weeks” at the end of treatment, suggesting that the benefits of calcium dobesilate treatment were becoming apparent at the end of the treatment period. These findings suggest the possibility of a sustained and progressive therapeutic effect of calcium dobesilate in CVI, possibly due to its anti-inflammatory actions, 31,32 which would presumably result in a sustained effect over the long term even after drug intake has been stopped. It may also be hypothesized that pain or discomfort improved because of the primary effects of calcium dobesilate on the venous system, and that these effects did not immediately translate into a lower level of edema.…”

Section: Discussionmentioning

confidence: 93%

A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency

2015

View full text Add to dashboard Cite

show abstract

In vitro effect of calcium dobesilate on oxidative/inflammatory stress in human varicose veins

Abstract: Calcium dobesilate protected human varicose veins against oxidative stress in vitro at levels that correspond to therapeutic concentrations. Further studies are required to investigate whether a similar action is found in varicose veins from patients orally treated with calcium dobesilate.

Cited by 21 publications

References 21 publications

Antioxidative mechanism in the course of varicose veins

Antioxidative mechanism in the course of varicose veins

Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials

A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency

Contact Info

Product

Resources

About