A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency

Rabe, Eberhard; Ballarini, Stefania; Lehr, Lorenz

doi:10.1177/0268355515586097

Cited by 29 publications

(7 citation statements)

References 22 publications

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“…We will consider this parameter in future studies. However, since a reduction in leg edema can be detected in long-term use (>3 weeks) of calcium dobesilate, and calcium dobesilate was administered in the study conducted by Rabe et.al and in our study, it may not have been possible to differentiate whether the reduction in edema was associated with subcutaneous lidocaine or calcium dobesilate 32 ) .…”

Section: Discussionmentioning

confidence: 66%

“…In this study, we used compression stockings, oral therapy (calcium dobesilate), and an exercise program, all of which are optimal methods for the treatment of this condition, and considered a conservative treatment protocol. We preferred calcium dobesilate, especially because it is well tolerated, and has a low side-effect profile 32 ) . Various agents and different methods have been used to treat patients with CVI.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of subcutaneous lidocaine injection in venous insufficiency: a prospective, randomized, controlled study, and new treatment protocol

Dernek¹,

Adıyeke

Duymuş

et al. 2018

J Phys Ther Sci

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[Purpose] The purpose of this study was to evaluate the efficacy of subcutaneous injection with lidocaine in patients with chronic venous insufficiency in the early stage. [Subjects and Methods] Patients (n=50) randomized to the treatment group received subcutaneous injections from a mixture of physiological saline sterile solution and lidocaine once a week to both legs below the knee for 5 sessions. Patients in the treatment group were also given ankle pumping exercises and compression stockings throughout the treatment. Patients randomized to the control group (n=50) received only ankle pumping exercises and compression stockings. Patients were evaluated using the visual analog scale (VAS) for pain and Chronic Venous Disease Quality of life Questionnaire (CIVIQ-20) for quality-of-life at months 1, 3, 6, at the end of month 12, and at the end of the injection treatment for 5 sessions. [Results] CIVIQ-20 and VAS results were significantly lower in the treatment group, than in the control group at months 1, 3 and 6. However, CIVIQ-20 and VAS results were not significantly different, compared with the pre-operative period at month 12. [Conclusion] We observed that 5-week subcutaneous lidocaine injection treatment was effective in patients who do not respond to oral medical treatment or in whom surgery is not considered.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Efficacy of subcutaneous lidocaine injection in venous insufficiency: a prospective, randomized, controlled study, and new treatment protocol

Dernek¹,

Adıyeke

Duymuş

et al. 2018

J Phys Ther Sci

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“…2 ). In contrast, studies comparing calcium dobesilate [ 15 , 19 , 20 ] or troxerutin [ 9 ] with placebo found no significant effect for these agents on QoL (Fig. 2 ).…”

Section: Impact Of Treatment On Qol In Cvd Patientsmentioning

confidence: 95%

Quality of Life in Chronic Venous Disease: Bridging the Gap Between Patients and Physicians

Santiago

2023

Clin Drug Investig

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Chronic venous disease (CVD) has a negative impact on patients’ quality of life (QoL). This was demonstrated in the recent Patient Journey on CVD study, which examined QoL in patients with early- and advanced-stage CVD (Clinical, Etiological, Anatomical and Pathophysiological classification C0 to C4), and the gaps between the way in which physicians and patients viewed the impact of CVD on QoL. The study was conducted in five countries (Brazil, China, Czech Republic, Italy and Russia) and included 100 patients with CVD and 60 CVD specialists. Patients completed the 14-item Chronic Venous Insufficiency Questionnaire (CIVIQ-14) to assess their QoL, and all patients and physicians were questioned during a 60-minute qualitative structured interview, focusing on four key dimensions—physical symptoms, aesthetics/appearance, emotional impact and impact on relationships. The study found that physicians tended to focus more on physical symptoms than on other impacts of CVD and rarely measured QoL in clinical practice. Patients were significantly less satisfied with the management of their QoL than physicians perceived them to be. About 25% of patients with CVD reported disturbed sleep, but physicians did not routinely ask them how CVD affected their sleep. These data reinforce the importance of physicians obtaining information about the impact of CVD on all aspects of the patient’s life, including sleep and QoL. Evidence from randomised controlled trials and real-world studies demonstrates that some veno-active drugs, particularly micronised purified flavonoid fraction, can positively impact QoL in patients with CVD.

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“…In pharmacological treatment, calcium dobesilate was found to be effective in reducing edema in C3-4 patients. 78,79 For various symptoms, other medications were also efficient, such as red vine leaf extract, 80 rutosides, 81 and sulodexide. 82 All had few adverse effects.…”

Section: Conservative or Non-invasive Treatmentmentioning

confidence: 99%

Brazilian guidelines on chronic venous disease of the Brazilian Society of Angiology and Vascular Surgery

Kikuchi,

Nhuch,

Drummond

et al. 2023

J. vasc. bras.

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The Brazilian Society of Angiology and Vascular Surgery has set up a committee to provide new evidence-based recommendations for patient care associated with chronic venous insufficiency. Topics were divided in five groups: 1. Classification, 2. Diagnosis, 3. Conservative or non-invasive treatment, 4. Invasive treatment and 5. Treatment of small vessels. This last series is closely related to the activities of Brazilian angiologists and vascular surgeons, who are heavily involved in the treatment of small superficial veins. These guidelines are intended to assist in clinical decision-making for attending physicians and health managers. The decision to follow a guideline recommendation should be made by the responsible physician on a case-by-case basis taking into account the patient's specific condition, as well as local resources, regulations, laws, and clinical practice recommendations.

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A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency

Cited by 29 publications

References 22 publications

Efficacy of subcutaneous lidocaine injection in venous insufficiency: a prospective, randomized, controlled study, and new treatment protocol

Efficacy of subcutaneous lidocaine injection in venous insufficiency: a prospective, randomized, controlled study, and new treatment protocol

Quality of Life in Chronic Venous Disease: Bridging the Gap Between Patients and Physicians

Brazilian guidelines on chronic venous disease of the Brazilian Society of Angiology and Vascular Surgery

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