<i>In vitro</i> degradation of starch/PVA films and biocompatibility evaluation

Shi, Rui; Zhu, Aichen; Chen, Dafu; Jiang, Xiujuan; Xu, Xiaochuan; Zhang, Liqun; Tian, Wei

doi:10.1002/app.31136

Cited by 50 publications

(29 citation statements)

References 47 publications

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“…Keeping in mind the rapid, initial decrease of iron oxide reported for oxidized starch-coated nanoparticles, 5 it is therefore conceivable that the PVA shell and the larger particle size of SPION microbubbles causes their slower degradation in macrophages. 30 These results indicate more stable iron loading into the administered SPION microbubbles. Using SPION incorporated into microbubbles as a vehicle for drug delivery might therefore result in more sustained release, and this should be investigated further.…”

mentioning

confidence: 87%

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

Barrefelt¹,

Saghafian²,

Kuiper³

et al. 2013

IJN

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mentioning

confidence: 87%

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

Barrefelt¹,

Saghafian²,

Kuiper³

et al. 2013

IJN

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“…After incubation of cells with extracts of the test sample and controls at 37 ±1 °C for 24 to 26 h, the culture was examined microscopically for cellular response. For negative control, the sample was prepared by incubating a 1.25 cm 2 polyethylene disc with 1 mL of culture medium with serum at 37 ±1 °C; a positive control was prepared by diluting phenol stock solution (13 mg/ml) with culture medium with serum (Shi et al 2010). …”

Section: Characterizationmentioning

confidence: 99%

Designing casein-coated iron oxide nanostructures (CCIONPs) as superparamagnetic core–shell carriers for magnetic drug targeting

Singh¹,

Bajpai²,

Tiwari

et al. 2014

Prog Biomater

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Magnetic drug targeting is a drug delivery system applicable to cancer treatment. Coated magnetic particles, called carriers, are very useful for delivering chemotherapeutic drugs. In the present research, casein-coated iron oxide nanocarriers (CCIONPs) of core shell nanostructure have been described as being applicable to magnetic drug targeting. The structure, morphology, and composition of prepared magnetic nanoparticles were determined by analytical techniques like Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Electron diffraction (ED), X-ray diffraction (XRD), Zeta potential, Dynamic light scattering (DLS), Mossbauer and Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), Vibrating sample magnetometery (VSM)) and in vitro cytotoxicity analysis. Magnetization studies of CCIONPs conducted at room temperature using a vibrating sample magnetometer suggested their superparamagnetic nature as having a saturation magnetization (Ms) of 64 emu g−1 at an applied magnetic field of 5 kOe. The size of the magnetic polymeric nanoparticles was found to lie in the range of 73.9 ±0.36 nm, and the particles exhibited superparamagnetic behavior. The prepared particles could be used as a drug carrier for controlled and targeted drug delivery.

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“…After a predetermined time interval, the films were withdrawn and weighed before and after drying and were studied for degradation characteristics such as swelling degree and weight loss [23,24]. Formulation of oral mucoadhesive gel systemIrinotecan loaded oral mucoadhesive gel was prepared using modified bora rice starch.…”

Section: In Vitro Degradation Studymentioning

confidence: 99%

Chemical Modification, Characterization and Evaluation of Mucoadhesive Potentiality of Assam Bora Rice Starch

Ahmed¹,

Bhaduri²

2017

Int J Pharm Pharm Sci

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Objective: The objective of the present study was to chemical modification, characterization and evaluation of mucoadhesive potentiality of Assam bora rice starch as potential excipients in the sustained release drug delivery system. Methods:The starch was isolated from Assam bora rice and esterified using thioglycolic acid and characterized by Fourier transform infrared spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and Nuclear magnetic resonance (NMR). The 10% w/v gel formulation based on modified bora rice starch loaded with irinotecan (0.6%) was prepared and evaluated for various rheological properties, ex-vivo mucoadhesion using goat intestine and in vitro drug release study in phosphate buffer pH 6.8. Results:The chemical modification was confirmed by FT-IR and NMR studies with the presence of the peak at 2626.74 cm -1 and a singlet at 2.51 respectively due to-SH group. Ex-vivo mucoadhesion studies showed 6.6 fold increases in mucoadhesion of the modified starch with compared to native starch (46.3±6.79g for native starch; 308.7±95.31g for modified starch). In vitro study showed 89.12±0.84 % of drug release after 6 h in phosphate buffer pH 6.8 and the release kinetics followed Non-Fickian diffusion. Conclusion:The modified Assam bora rice starch enhanced a mucoadhesive property of the native starch and thus, can be explored in future as a potential excipient for the sustained release mucoadhesive drug delivery system.

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In vitro degradation of starch/PVA films and biocompatibility evaluation

Cited by 50 publications

References 47 publications

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

Designing casein-coated iron oxide nanostructures (CCIONPs) as superparamagnetic core–shell carriers for magnetic drug targeting

Chemical Modification, Characterization and Evaluation of Mucoadhesive Potentiality of Assam Bora Rice Starch

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