In Vitro Characterization of the OptiChamber Diamond Valved Holding Chamber

Abstract

The two antistatic VHCs were equivalent for both pMDI brands. Aerosol delivered from the antistatic VHCs at 15 L/min had a higher proportion of fine particles compared with the conventional VHC.

Drug Delivery from an Innovative LAMA/LABA Co-suspension Delivery Technology Fixed-Dose Combination MDI: Evidence of Consistency, Robustness, and Reliability

“…GFF MDI demonstrated delivery of a consistent FPF for flow rates of 30-90 L/min, which may help to provide reliable dosing to patients with COPD with variable peak inhalation flow rates and volumes. These results are higher than, or comparable with, other MDIs, including an ultrafine solution-based formulation (23)(24)(25)(26)(27). The flow rate independence of other MDIs has previously been shown, but across a narrower range of flow rates (24,27,32).…”

Lung Deposition of 99mTc-Radiolabeled Albuterol Delivered through a Pressurized Metered Dose Inhaler and Spacer with Facemask or Mouthpiece in Children with Asthma

“…(23) The medium LiteTouch facemask, intended for use with the Diamond spacer, included a soft, contoured silicone edge and a rigid, transparent shell.…”

In Vitro Comparison of the Effect of Inhalation Delay and Flow Rate on the Emitted Dose from Three Valved Holding Chambers

“…The results showed equivalence for the Diamond VHC with the predicate device, the AC Z-Stat VHC. (16) Emitted dose was representative of the dose of drug available to inhalation via each VHC, when ProAir HFA was used under the conditions tested. Our results indicated that for all three VHCs, the emitted dose was reduced when the length of the inhalation delay increased.…”

“…(16) The present article reports on the interaction between clinically relevant inhalation delays (0, 5, and 10 sec) and extraction flow rates (5,15, and 30 L/min), using a conventional VHC and two brands of antistatic VHC. The dose of albuterol delivered to a filter (emitted dose) was determined for each of the combinations of inhalation delay, flow rate, and VHC brand.…”