In vitro bioactivity of melt‐derived glass 46S6 doped with magnesium

Abstract

Melt-derived glasses in the system SiO(2)-CaO-Na(2)O-P(2)O(5) were synthesized pure or doped with magnesium from 0.4 to 1.2 wt %, for applications as biomaterials in bony surgery. This chemical element has been chosen because of its high physiological interest. Its introduction for different contents in melt derived glasses has never been studied. The bioactivity of glasses was assessed by immersion of the samples in the simulated body fluid solution. Changes in glass surface morphology and composition after immersion were evaluated by several physico-chemical techniques. The aim of this work was to characterize the formation of the apatite-like layer at the glass surface, after in vitro assays and to evaluate the kinetic reaction between the glass and the surrounding synthetic fluids. Results indicate that magnesium influences the formation and the evolution of the newly formed layers: (1) it promotes the dissolution of the silica network, (2) it increases the thickness of the silica gel layer formed conventionally prior to the apatite-like layer, and (3) it slows down the crystallization of the apatite layer. However, the intensity of these effects depends on the content of magnesium introduced in the glass matrix.

Physical and biological characteristics of nanohydroxyapatite and bioactive glasses used for bone tissue engineering

“…The SBF solution was prepared by dissolving NaCl, NaHCO 3 , KCl, K 2 HPO 4 ·3H 2 O, MgCl 2 ·6H 2 O, and CaCl 2 in deionized water and buffering with (CH 2 OH) 3 CNH 2 and HCl 6N to obtain a pH value of 7.4 according to Kokubo's technique [140,141]. The ionic composition of this solution is shown in Table 6.…”

Development of magnesium calcium phosphate biocement for bone regeneration

“…Previous studies have reported that ion-dissolution products containing Ca and Mg from bioactive glasses and ceramics could stimulate cell proliferation (Dietrich et al 2009;Sader et al 2009). It is believed that the release of Mg ions from corroding Mg alloys should not cause toxicity (local or systemic), and may even have beneficial effects on cell responses, in the relevant local tissue (Staiger et al 2006;Witte et al 2007).…”

Thermal investigations of Ti and Ag-doped bioactive glasses

“…Their bioactive character results of their ability to form a hydroxyapatite layer Ca 10 (PO 4 ) 6 (OH) 2 on their surface when they are immersed in a simulated body fluid (SBF) [4-5-6]. The hydroxyapatite is the major inorganic compound of the human bone.…”