<i>In Vitro</i> Bioactive Characteristics of Borate‐Based Glasses with Controllable Degradation Behavior

Yao, Aihua; Wang, Deping; Huang, Wenhai; Fu, Qiang; Rahaman, Mohamed N.; Day, Delbert E.

doi:10.1111/j.1551-2916.2006.01358.x

Cited by 263 publications

(308 citation statements)

References 11 publications

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“…However, the degradation of this silicon-based glass is highly timedependent, and the bulk material was reported to remain in the human body upto one year of implantation (Hamadouche et al 2001). As a result, borate glass, based on a B 2 O 3 network, is now showing potential in bone regeneration, owing to its complete conversion to apatite through a set of dissolutionprecipitation reactions similar in nature to those in 45S5 Bioglass (Huang et al 2006;Yao et al 2007;Liu et al 2009b). In particular, the mechanical strength of a scaffold based on a boron network former is significantly higher than that of the silicon network former in 45S5 Bioglass (Liu et al 2009a).…”

Section: Introductionmentioning

confidence: 99%

Strontium borate glass: potential biomaterial for bone regeneration

Pan

Zhao

Zhang

et al. 2009

J. R. Soc. Interface.

146

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Boron plays important roles in many life processes including embryogenesis, bone growth and maintenance, immune function and psychomotor skills. Thus, the delivery of boron by the degradation of borate glass is of special interest in biomedical applications. However, the cytotoxicity of borate glass which arises with the rapid release of boron has to be carefully considered. In this study, it was found that the incorporation of strontium into borate glass can not only moderate the rapid release of boron, but also induce the adhesion of osteoblast-like cells, SaOS-2, thus significantly increasing the cyto-compatibility of borate glass. The formation of multilayers of apatite with porous structure indicates that complete degradation is optimistic, and the spread of SaOS-2 covered by apatite to form a sandwich structure may induce bone-like tissue formation at earlier stages. Therefore, such novel strontium-incorporated borosilicate may act as a new generation of biomaterial for bone regeneration, which not only renders boron as a nutritious element for bone health, but also delivers strontium to stimulate formation of new bones.

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Section: Introductionmentioning

confidence: 99%

Strontium borate glass: potential biomaterial for bone regeneration

Pan

Zhao

Zhang

et al. 2009

J. R. Soc. Interface.

146

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“…The initial burst of release of TEC could be attributed to the rapid dissolution of TEC from the surface region of the TBG implants. Concurrently, the Ca 2ϩ ions released from the borate glass can react with the (PO 4 ) 3Ϫ ions from the solution to form an HA layer on the surface of the TBG implant, which thickens with time (14,27) and presumably contributes to a reduction in the rate of TEC release.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Borate Bioactive Glass and Calcium Sulfate as Implants for the Local Delivery of Teicoplanin in the Treatment of Methicillin-Resistant Staphylococcus aureus-Induced Osteomyelitis in a Rabbit Model

Jia

Huang

et al. 2015

Antimicrob Agents Chemother

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There is growing interest in biomaterials that can cure bone infection and also regenerate bone. In this study, two groups of implants composed of 10% (wt/wt) teicoplanin (TEC)-loaded borate bioactive glass (designated TBG) or calcium sulfate (TCS) were created and evaluated for their ability to release TEC in vitro and to cure methicillin-resistant Staphylococcus aureus (MRSA)-induced osteomyelitis in a rabbit model. When immersed in phosphate-buffered saline (PBS), both groups of implants provided a sustained release of TEC at a therapeutic level for up to 3 to 4 weeks while they were gradually degraded and converted to hydroxyapatite. The TBG implants showed a longer duration of TEC release and better retention of strength as a function of immersion time in PBS. Infected rabbit tibiae were treated by debridement, followed by implantation of TBG or TCS pellets or intravenous injection with TEC, or were left untreated. Evaluation at 6 weeks postimplantation showed that the animals implanted with TBG or TCS pellets had significantly lower radiological and histological scores, lower rates of MRSA-positive cultures, and lower bacterial loads than those preoperatively and those of animals treated intravenously. The level of bone regeneration was also higher in the defects treated with the TBG pellets. The results showed that local TEC delivery was more effective than intravenous administration for the treatment of MRSA-induced osteomyelitis. Borate glass has the advantages of better mechanical strength, more desirable kinetics of release of TEC, and a higher osteogenic capacity and thus could be an effective alternative to calcium sulfate for local delivery of TEC. Bacterial infection resulting from orthopedic surgery is a serious complication. The pathogenic organisms responsible for such infections are often resistant to multiple drugs. Methicillinresistant Staphylococcus aureus (MRSA) has become the most common osteomyelitis-inducing microorganism clinically (1, 2). Currently, the main treatment for chronic osteomyelitis includes surgical debridement and prolonged systemic antibiotic therapy over a course of several weeks. As an antibiotic, teicoplanin (TEC) has a long serum half-life and broad-spectrum antibacterial activity against most Gram-positive aerobic and anaerobic organisms such as MRSA and methicillin-resistant coagulase-negative S. aureus (3). Compared to vancomycin (a more widely used antibiotic), the use of TEC also results in less ototoxicity, nephrotoxicity, and gastrointestinal side effects. Because of its favorable pharmacokinetics, TEC is commonly used in Europe to treat osteomyelitis (4).Even after thorough debridement, residual infection often remains in the bone. The surgical procedure also creates a bone defect that usually requires subsequent reconstruction (5). Furthermore, nidus formation considerably limits the efficacy of systemic antibiotic therapy because of the compromised vascular perfusion at the infected site. High concentrations of antibiotics in the blood resulting from long-t...

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“…Using 15 mL polypropylene Falcon tubes, 0.1 g of each glass composition (45 -150 µm) (n=3) was suspended in 10 mL of tissue culture water (Sigma-Aldrich, Canada) [40][41][42][43]. This was done for each glass composition at each incubation time point: 24, 72, 168, 336 and 720 hours.…”

Section: Quantification Of Inorganic Ion Release Under Simulated Physmentioning

confidence: 99%

High Borate Networks as a Platform to Modulate Temporal Release of Therapeutic Metal Ions Gallium and Strontium

O'Connell¹,

Werner‐Zwanziger²,

O’Shea³

et al. 2017

Biomedical Glasses

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Abstract:The effect of increasing substitutions of Ga 2 O 3 :Na 2 O on the structure and contingent properties, of six quaternary high borate glasses was evaluated. Component ion release and particularly gallium ion release was studied post extraction, under simulated physiological conditions. Increasing substitutions of Ga 2 O 3 :Na 2 O (i.e. 0:1 -6:4) resulted in destabilization of the glass network, observed by increases in component ion release and half-life of release. However, at ≥ 6:4 Ga 2 O 3 :Na 2 O ratio, network stabilization appeared to occur, resulting in a decrease in ion release half-life and total ion release for B, Sr, and Ga at 720 h of extraction. A linear release profile for strontium was provided by each glass composition, and for gallium by composition GB202 (70B

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In Vitro Bioactive Characteristics of Borate‐Based Glasses with Controllable Degradation Behavior

Cited by 263 publications

References 11 publications

Strontium borate glass: potential biomaterial for bone regeneration

Strontium borate glass: potential biomaterial for bone regeneration

Comparison of Borate Bioactive Glass and Calcium Sulfate as Implants for the Local Delivery of Teicoplanin in the Treatment of Methicillin-Resistant Staphylococcus aureus-Induced Osteomyelitis in a Rabbit Model

High Borate Networks as a Platform to Modulate Temporal Release of Therapeutic Metal Ions Gallium and Strontium

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