<i>In vitro</i>antiplasmodial and antimicrobial potential of<i>Tagetes erecta</i>roots

Gupta, Pankaj; Vasudeva, Neeru

doi:10.3109/13880201003695142

Cited by 23 publications

(22 citation statements)

References 11 publications

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“…Previous studies from our laboratory evaluated the antiplasmodial and antimicrobial potential of the crude successive extracts viz. petroleum ether, chloroform, ethyl acetate, methanol, and aqueous extracts of the roots of T. erecta (Gupta & Vasudeva, 2010). In the present study, we undertook an evaluation of the root extract for antioxidant activity using diphenylpicrylhydrazyl (DPPH) radical scavenging assay and its cytotoxic potential against prostate and HeLa cancer cell lines.…”

Section: Research Articlementioning

confidence: 99%

Antioxidant and cytotoxic potential of a new thienyl derivative fromTagetes erectaroots

Gupta

Agarwal

et al. 2012

Pharmaceutical Biology

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Section: Research Articlementioning

confidence: 99%

Antioxidant and cytotoxic potential of a new thienyl derivative fromTagetes erectaroots

Gupta

Agarwal

et al. 2012

Pharmaceutical Biology

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“…As a result, all the extracts exhibited significant antimicrobial activities against three Gram-positive and two Gram-negative bacterial species (23).…”

Section: Discussionmentioning

confidence: 96%

Tagetes erecta, A Potential Medicinal Plant for Discovering a New Antibacterial Agent

Motamedi

Seyyednejad

Bakhtiari

et al. 2015

Jentashapir J Health Res

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Background: Tagetes genus contains 56 species and is native in North and South America, but some have become widespread around the world. Objectives: This study was designed to examine the antibacterial potential of methanolic and ethanolic extracts of Tagetes erecta. Materials and Methods: Hydroalcoholic extracts from aerial parts of this plant were prepared using aqueous solution of ethanol and methanol (8:2 v/v). The inhibitory effect of 1.5, 3, 6, 12 and 18 mg of effective dose per disc of these extracts was discovered against clinical bacterial isolates including three Gram-positive bacteria: Bacillus cereus, Staphylococcus aureus and S. epidermidis and five Gram-negative bacteria: Salmonella Typhi, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Proteus mirabilis. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time kill kinetic assay of these extracts were also investigated. Scanning electron microscopy (SEM) analysis was performed to find possible structural changes following exposure to the extract. Results: Both extracts of T. erecta were active against B. cereus, S. aureus, S. epidermidis and S. Typhi. Hydroalcoholic extracts of T. erecta showed significant antibacterial effects against some clinically important pathogenic bacteria. These extract also caused deformation and lysis of bacterial cells, as shown by SEM. Conclusions: These extracts can be used as antibacterial agents in treating infectious diseases. Further studies are needed for considering this plant as an antibacterial plant and benefit from its clinical applications for routine use.

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“…Thiopene derivatives α-terthienyl and 5-butyl-2,2′-bithienyl were found in the roots (Vasudevan et al 1997 ). A new bithienyl compound, 2-hydroxymethylnon-3-ynoic acid 2-[2,2′]-bithiophenyl-5-ethyl ester from the roots of T. erecta (Gupta and Vasudeva 2010 ). Wang et al ( 2002 ) isolated thiopene derivatives: 5,5′-dimethyl-2,2′-bithienyl; 5-vinyl-2,2′-bithiophene and 5-(3-butene-1-ynyl)-2,2′-bithiophene; and fl avonoids: quercetagetin 3-O -glucoside and kaempferol.…”

Section: Root Phytochemicalsmentioning

confidence: 97%

“…erecta essential leaf oil completely inhibited the growth of Fusarium oxysporum and Trichophyton mentagrophytes (Rai and Acharya 1999 ). T. erecta root extracts (petroleum ether, chloroform, ethyl acetate, methanol and aqueous) exhibited signifi cant antimicrobial activity against three Gram-positive and two Gramnegative bacterial and two fungal strains with MIC values ranging between 12.5 and 100 μg/ml (Gupta and Vasudeva 2010 ). Methanol extract of Tagetes erecta at 40 mg/ml concentration was found to have better inhibitory activity when compared to cold and hot aqueous extracts .…”

Section: Antimicrobial Activitymentioning

confidence: 98%

“…Among T. erecta root extracts tested, ethyl acetate extract exhibited signifi cant antiplasmodial effi cacy with the 50 % inhibitory concentrations (IC 50 ) of 0.02 and 0.07 mg/ml against the chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum , respectively (Gupta and Vasudeva 2010 ). The new bithienyl compound, 2-hydroxymethyl-non-3-ynoic acid 2-[2,2′]-bithiophenyl-5-ethyl ester, also showed signifi cant schizonticidal activity against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum with the IC 50 values of 0.01 and 0.02 mg/ml.…”

Section: Antiplasmodial Activitymentioning

confidence: 99%

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