Antioxidant and cytotoxic potential of a new thienyl derivative from<i>Tagetes erecta</i>roots

Gupta, Pankaj; Gupta, Atul; Agarwal, Krati; Tomar, Priti; Satija, Saurabh

doi:10.3109/13880209.2012.655378

Cited by 25 publications

(15 citation statements)

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“…Despite polyphenol absence TMO exhibited significant radical scavenging activity. This antioxidant activity was confirmed by previous researches with IC50 between 35 and 344 lg/mL (Gong et al 2012;Gupta et al 2012;Perez-Cruz et al 2013). Thus, TMO analyzed in this research showed stronger antioxidant activity compared to previously analyzed TMOs.…”

Section: Discussionsupporting

confidence: 89%

“…Cytotoxic activity of the ethanol extract of T. eracta roots against prostate (PC-3) and HeLa cancer cell lines was investigated by Gupta et al using MTT assay. The extract conferred noticeable cytotoxicity against both PC-3 and HeLa cell lines with IC 50 of 407 and 164 lg/mL, respectively (Gupta et al 2012), which are lower rather than TMO analyzed in this research. The results of MTT assay indicated that OBO had no effects on the viability of KB and HepG2 cells at low concentrations (<10 lg/mL).…”

Section: Discussionmentioning

confidence: 64%

“…The extract conferred noticeable cytotoxicity against both PC‐3 and HeLa cell lines with IC 50 of 407 and 164 μ g/mL, respectively (Gupta et al. ), which are lower rather than TMO analyzed in this research. The results of MTT assay indicated that OBO had no effects on the viability of KB and HepG2 cells at low concentrations (<10 μ g/mL).…”

Section: Discussionmentioning

confidence: 74%

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Chemical composition, antioxidant, antimicrobial and cytotoxic activities of Tagetes minuta and Ocimum basilicum essential oils

Shirazi

Gholami

Kavoosi

et al. 2014

Food Science & Nutrition

126

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Chemical composition, antioxidant, antimicrobial and cytotoxic activities of Tagetes minuta (TM) essential oil (TMO) and Ocimum basilicum (OB) essential oil (OBO) were examined. The main components for TMO were dihydrotagetone (33.9%), E-ocimene (19.9%), tagetone (16.1%), cis-β-ocimene (7.9%), Z-ocimene (5.3%), limonene (3.1%) and epoxyocimene (2.03%). The main components for OBO were methylchavicol (46.9%), geranial (19.1%), neral (15.15%), geraniol (3.0%), nerol (3.0%), caryophyllene (2.4%). Inhibitory concentrations (IC50) for reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenging were 12–17 and 200–250 μg/mL of TMO and OBO, respectively. Minimal inhibitory concentration (MIC) against Salmonella typhi,Escherichia coli,Staphylococcus aureus,Bacillus subtilis,Aspergillus niger, and Candida albicans were 150 ± 8, 165 ± 9, 67 ± 8, 75 ± 7, 135 ± 15, and 115 ± 8 μg/mL of TMO, respectively. MIC for S. typhi,E. coli,S. aureus,B. subtilis,A. niger, and C. albicans were 145 ± 8, 160 ± 7, 45 ± 4, 40 ± 3, 80 ± 9, and 95 ± 7 μg/mL of OBO, respectively. IC50 for nasopharyngeal cancer cell line (KB) and liver hepatocellular carcinoma cell line (HepG2) were 75 ± 5 and 70 ± 4 μg/mL of TMO, respectively. IC50 for KB and HepG2 were 45 ± 4 and 40 ± 3 μg/mL of OBO, respectively. Thus, they could be used as an effective source of natural antioxidant and antibacterial additive to protect foods from oxidative damages and foodborne pathogens. Furthermore, they could be promising candidate for antitumor drug design.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 74%

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Chemical composition, antioxidant, antimicrobial and cytotoxic activities of Tagetes minuta and Ocimum basilicum essential oils

Shirazi

Gholami

Kavoosi

et al. 2014

Food Science & Nutrition

126

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“…A literature survey revealed that T. erecta possesses a wide spectrum of phytochemical constituents that are used as remedies to treat various health problems, including piles, wounds, fevers, stomachic, rheumatism, scabies and liver troubles, and is also utilized for eye treatments [1]. However, one of the most complex mixture components in T. erecta is the essential oil with volatile and aromatic properties, which exhibit effective pharmacological activities like anti-inflammatory [2], insecticidal [3], larvicidal [4], antimicrobial [5], antioxidant [6], anticancer [7], as well as allelopathy efficacy [8]. The present study has been undertaken to isolate the EO from TES, TEF, and TER parts of T. erecta using the GC-MS technique, and to evaluate their antifungal and cytotoxic activities.…”

Section: Introductionmentioning

confidence: 99%

Screening of Chemical Characterization, Antifungal and Cytotoxic Activities of Essential Oil Constituents of <i>Tagetes erecta</i> L. from Erbil, Kurdistan Region-Iraq

Safar¹,

Ghafoor²,

Dastan³

2020

Pol. J. Environ. Stud.

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Ethnopharmacologic relevance: The history of health benefits of Tagetes (Asteraceae) dates back at least to the 12 th century. Tagetes erecta, an important specie from this genus, was widely known for its traditional medicine. Different parts of T. erecta are used in folk medicine to cure various types of diseases. Aim of the study: Considering the lack of scientific studies of Tagetes, the present study was aimed to evaluate the chemical composition, antifungal activity of its essential oil against fungi responsible for human infections, as well as its cytotoxicity on HepG2 human liver carcinoma cell lines. Materials and methods: Clevenger-type was performed to hydrodistillate EOs and chemically analyzed by combination of GC and MS technique, followed by the evaluation of antifungal activity by using the broth microdilution method. The cytotoxicity was evaluated through MTT assay against HepG2 and expressed as IC 50. Results: One hundred and eleven compounds of the total EOs were identified from three parts (shoot, flower, and root). For the first time, more than 60 new compounds such as iso-bergapten, bergapten, (3)-thujanol acetate, sylvestrene, α-vetivone, tridecenol acetate, β-atlantol, and p-cymenene have been isolated from T. erecta. Among all yeasts, C. albicans was the most sensitive with MICs of 0.08, 0.04, 0.16 µL mL-1 for TES, TEF, and TER oil respectively. In addition, maximum apoptosis rate of up to 90% was observed for HepG2 cell line at concentrations ranging between 82 and 122 µg/ml, with IC 50 value from 11.58 µg mL-1 to 19.86 µg mL-1 Conclusion: The findings from this study showed that the chemical composition of T. erecta EO varies, depending on the geographical situation, extraction method, environmental factors, and plant

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“…The ethanol extract of T. erecta roots scavenged DPPH free radicals thereby exhibiting antioxidant activity with an IC 50 of 35.9 μg/ml and conferred marked cytotoxicity against the HeLa (LD 50 of 164.28 μg/ml) and PC-3 cell lines (LD 50 of 407.3 μg/ml) (Gupta et al 2012 ). Among the 21 isolates obtained, T 3 showed antioxidant activity with IC 50 of 11.56 μg/ml and cytotoxicity with LD 50 of 12.5 μg/ml against HeLa and 30.25 μg/ml against prostate PC-3 cell lines and was characterized as 2-ethynyl-5-(thiophen-2-yl) thiophene.…”

Section: Antiproliferative/cytotoxicity Activitymentioning

confidence: 99%

Tagetes erecta

Lim¹

2013

Edible Medicinal and Non-Medicinal Plants

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Antioxidant and cytotoxic potential of a new thienyl derivative fromTagetes erectaroots

Cited by 25 publications

References 8 publications

Chemical composition, antioxidant, antimicrobial and cytotoxic activities of Tagetes minuta and Ocimum basilicum essential oils

Chemical composition, antioxidant, antimicrobial and cytotoxic activities of Tagetes minuta and Ocimum basilicum essential oils

Screening of Chemical Characterization, Antifungal and Cytotoxic Activities of Essential Oil Constituents of <i>Tagetes erecta</i> L. from Erbil, Kurdistan Region-Iraq

Tagetes erecta

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