<i>In Vitro</i> Antimicrobial Evaluation of Coated VICRYL* Plus Antibacterial Suture (Coated Polyglactin 910 with Triclosan) using Zone of Inhibition Assays

Rothenburger, Stephen; Spangler, Daniel; Bhende, Shubhangi; Burkley, Daniel

doi:10.1089/sur.2002.3.s1-79

Cited by 139 publications

(55 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…39 In vivo studies on triclosan-coated sutures exhibited significant inhibition of bacterial colonies on its surface near the infected site without compromising the mechanical property of the suture. 7 In the present study, there was no significant difference of age and gender distribution among both the groups.…”

Section: Discussioncontrasting

confidence: 48%

A comparative study to test the effectiveness of triclosan coated polyglactin 910 in reduction of surgical site infection in clean wounds

et al. 2019

View full text Add to dashboard Cite

Background: Surgical site infection (SSI) has been pointed out as the 2nd most common nosocomial infection. Since suture materials have been proven to be a contributor to SSI, they have been the focus of research and development centered on making them less conducive to bacterial overgrowth. The Triclosan coated suture slowly releases Triclosan, which is an antibacterial agent that inhibits bacterial colonization of the suture and wound site and thus, promises prevention of surgical site infection.Methods: Total of 100 patients undergoing excision of uninfected subcutaneous benign lumps and cutaneous swellings were randomized in two groups: group A in which triclosan coated polyglactin 910 suture was used for wound closure (50 patients) and Group B in whom conventional uncoated Polyglactin 910 suture was used for wound closure (50 patients).Results: In this study, maximum number of patients was in the age group of 46-60 years. Mean age of subjects in triclosan- coated suture group was 45.03 years while it was 47.32 in conventional uncoated suture group. Among 100 subjects in triclosan- coated suture group, 26 (52%) were males and 24 (48%) were females. In comparison to it, male and female subjects in conventional uncoated suture group were 25 (50%) each. Among 50 subjects in triclosan- coated suture group, only 2 (4.0%) had surgical site infection while in conventional uncoated suture group, 8 (16.0%) had surgical site infection. Incidence of surgical site infection with use of triclosan- coated suture was significantly lower compared to conventional uncoated suture group. (p 0.04).Conclusions: Triclosan coated suture surely, helps in preventing surgical site infection which, not only increases the morbidity of the patient but also has long-term implications.

show abstract

Section: Discussioncontrasting

confidence: 48%

A comparative study to test the effectiveness of triclosan coated polyglactin 910 in reduction of surgical site infection in clean wounds

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Rothenburger et al have evaluated a coated polyglactin 910 suture with triclosan for its antibacterial effectiveness against staphylococci [23]. They report a sufficient anti-microbial effect to prevent in vitro colonization caused by S. aureus and S. epidermidis.…”

Section: Discussionmentioning

confidence: 99%

New Anti-infective Coatings of Surgical Sutures Based on a Combination of Antiseptics and Fatty Acids

Matl

Zlotnyk

Obermeier

et al. 2009

Journal of Biomaterials Science, Polymer Edition

View full text Add to dashboard Cite

Wound infection is a complication feared in surgery. The aim of this study was to develop new anti-infective coatings of surgical sutures and to compare the anti-microbial effectiveness and biocompatibility to the well-established Vicryl Plus. Synthetic absorbable PGA surgical sutures were coated with three different chlorhexidine concentrations and two different octenidine concentrations in combination with palmitic acid and lauric acid. Drug-release kinetics lasting 96 h were studied in phosphate-buffered saline at 37 degrees C. Anti-infective characteristics were determined by measuring the change in optical density of Staphylococcus aureus suspensions charged with coated sutures over time. Microorganisms adsorbed at the surface of coated sutures were assessed on blood agar plates and coated sutures eluted for 24 h were placed on bacterial lawns cultured on Mueller-Hinton plates to prove retained anti-microbial potency. A cell proliferation assay was performed to assess the degree of cytotoxicity. Anti-infective characteristics and biocompatibility were compared to Vicryl Plus. A coating technology for slow-release drug-delivery systems on surgical sutures could be developed. All coatings showed a continuous drug release within 96 h. Individual chlorhexidine and octenidine coated sutures showed superior anti-infective characteristics but inferior biocompatibility in comparison to Vicryl Plus. We conclude that the developed anti-infective suture coatings consisting of lipid-based drug-delivery systems in combination with antiseptics are highly effective against bacterial colonization in vitro; however, drug doses have to be adjusted to improve biocompatibility.

show abstract

“…Preventing bacterial attachment and growth on implanted sutures is a strategy that has recently been proposed to improve the performance of such materials 5. It is well known that synthetic absorbable sutures can be classified into monofilament and braided sutures on the basis of their filament structure.…”

Section: Introductionmentioning

confidence: 99%

Incorporation of triclosan into polydioxanone monofilaments and evaluation of the corresponding release

Blanco

Franco

Puiggalı́

et al. 2009

J of Applied Polymer Sci

View full text Add to dashboard Cite

Poly(p-dioxanone) monofilaments were loaded with triclosan, a drug with a well-known antimicrobial effect. Two different procedures were considered: loading by molecular diffusion with a swelling solvent such as dichloromethane and loading by means of a coating based on polycaprolactone or polycaprolactone/magnesium stearate mixtures. Triclosan release was studied in different media by high-performance liquid chromatography. The kinetics of loading by diffusion and the release from both kinds of preparations were evaluated with wellestablished models. In general, the first stages of the loading process fit with the Higuchi approximation, whereas the final stages fit with the first-order model. The last model could be applied to predict the release behavior. A sustained release over a period that could reach 400 h was attained when ethanol was added to the release medium, whereas equilibrium conditions were reached when Sö rensen's hydrophilic medium was used. Significant differences in the release profiles of a Sö rensen's/ethanol medium were observed, which depended on the loading methodology. Thus, an 80% release was attained after 36 h for a polycaprolactone-coated sample and after 80-100 h for a sample loaded by diffusion. Degradation studies of the triclosan-loaded samples were also performed because the increase in the hydrophobicity of the samples could hinder the hydrolytic degradation. The weight-average molecular weight of unloaded and loaded (29,075 lg/g) sutures dropped to 220.000 and 110.000 after 45 days of exposure to the medium at 37 C, respectively.

show abstract

In Vitro Antimicrobial Evaluation of Coated VICRYL* Plus Antibacterial Suture (Coated Polyglactin 910 with Triclosan) using Zone of Inhibition Assays

Abstract: These data support the conclusion that coated polyglactin 910 suture with triclosan provides antimicrobial effect sufficient to prevent in vitro colonization by S. aureus and S. epidermidis.

Cited by 139 publications

References 8 publications

A comparative study to test the effectiveness of triclosan coated polyglactin 910 in reduction of surgical site infection in clean wounds

A comparative study to test the effectiveness of triclosan coated polyglactin 910 in reduction of surgical site infection in clean wounds

New Anti-infective Coatings of Surgical Sutures Based on a Combination of Antiseptics and Fatty Acids

Incorporation of triclosan into polydioxanone monofilaments and evaluation of the corresponding release

Contact Info

Product

Resources

About