In vitro
 antimicrobial combinatory effect of
 Cinnamomum cassia
 essential oil with 8‐hydroxyquinoline against
 Staphylococcus aureus
 in liquid and vapour phase

Netopilova, M; Houdková, Markéta; Urbanová, Klára; Rondevaldova, Johana; Damme, Petra Van; Kokoška, Ladislav

doi:10.1111/jam.14683

Cited by 15 publications

(12 citation statements)

References 32 publications

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“…Moreover, a number of non-antimicrobial therapeutic agents, including ibuprofen, have been found to play a role in multidrug-resistant infections such as methicillin-resistant Staphylococcus aureus (MRSA). Furthermore, there is an increasing interest in the efficacy of herbal products and essential oils as a health remedy for the control of drug resistance issues, which may be due to the synergistic influence of bioactive compounds [ 75 , 76 ]. For example, GeloMyrtol (G. PohlBoskamp, Hohenlockstedt, Germany) is a notable herbal medicine used to treat asthma and sinusitis.…”

Section: Resultsmentioning

confidence: 99%

“…For example, GeloMyrtol (G. PohlBoskamp, Hohenlockstedt, Germany) is a notable herbal medicine used to treat asthma and sinusitis. GeloMyrtol is extracted from a variety of essential oils provided by Citrus limon , Camellia sinensis , Eucalyptus globulus , and Myrtus communis [ 76 ]. Therefore, we believe that the medicinal properties of Cassia timoriensis might have the potential to be developed as herbal products with antimicrobial properties in the future.…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers

et al. 2021

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Despite being widely used traditionally as a general tonic, especially in South East Asia, scientific research on Cassia timoriensis, remains scarce. In this study, the aim was to evaluate the in vitro activities for acetylcholinesterase (AChE) inhibitory potential, radical scavenging ability, and the anti-inflammatory properties of different extracts of C. timoriensis flowers using Ellman’s assay, a DPPH assay, and an albumin denaturation assay, respectively. With the exception of the acetylcholinesterase activity, to the best of our knowledge, these activities were reported for the first time for C. timoriensis flowers. The phytochemical analysis confirmed the existence of tannins, flavonoids, saponins, terpenoids, and steroids in the C. timoriensis flower extracts. The ethyl acetate extract possessed the highest phenolic and flavonoid contents (527.43 ± 5.83 mg GAE/g DW and 851.83 ± 10.08 mg QE/g DW, respectively) as compared to the other extracts. In addition, the ethyl acetate and methanol extracts exhibited the highest antioxidant (IC50 20.12 ± 0.12 and 34.48 ± 0.07 µg/mL, respectively), anti-inflammatory (92.50 ± 1.38 and 92.22 ± 1.09, respectively), and anti-AChE (IC50 6.91 ± 0.38 and 6.40 ± 0.27 µg/mL, respectively) activities. These results suggest that ethyl acetate and methanol extracts may contain bioactive compounds that can control neurodegenerative disorders, including Alzheimer’s disease, through high antioxidant, anti-inflammatory, and anti-AChE activities.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers

et al. 2021

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“…Much safer than cypermethrin, C. verum and C. cassia EOs as well as cinnamaldehyde provided a high toxicity against mosquitoes but are non-toxic to humans, other mammals, or bene cial insects [19][20]60 . Furthermore, they are easily degraded in the environment, and they have already been used for ages by Asian people as an anti-microbial agent in their local medicine [45][46][47][48] .…”

Section: Discussionmentioning

confidence: 99%

“…albopictus. We had selected to investigate these three EOs among numerous plant EOs because they have been reported to possess pharmaceutical, antifungal, antibacterial and insecticidal properties as well as to be safe for human and the environment [45][46][47][48] . EO combinations that showed a highly synergistic effect can be developed into effective adulticidal agents for controlling and managing Aedes mosquitoes in urban and rural areas as well as for controlling dengue diseases and other vector-borne diseases.…”

Section: Introductionmentioning

confidence: 99%

Improved adulticidal activity against Aedes aegypti (L.), and Aedes albopictus (Skuse), from synergy between Cinnamomum spp. essential oils

Aungtikun

Soonwera

2020

Preprint

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Improved natural adulticidal agents against mosquito vectors are in urgent need, and essential oils from Cinnamomum plants can assume this role quite readily. Cinnamomum verum, C. cassia, and C. loureiroi essential oils (EOs) were extracted from the barks and evaluated for their chemical composition by GC-MS. The major constituent of the three EOs was cinnamaldehyde. WHO susceptibility tests on individual and combined EOs as well as cinnamaldehyde were conducted against female adults of Aedes aegypti and Aedes albopictus. All EO combinations exhibited a synergistic effect, manifesting a higher toxicity, with a synergistic value ranging from 2.9-6.7. Their increasing mortality value was improved between 16.0 to 41.7%. The highest synergistic effect was achieved by an EO combination of 0.5% C. cassia + 0.5% C. loureiroi, while the highest insecticidal activity was achieved by 2.5% C. verum + 2.5% C. cassia and 1% cinnamaldehyde, with a knockdown and mortality rate of 100% and a KT50 between 0.7-2.1 min. This combination was more toxic to both mosquito species than 1% w/v cypermethrin. These findings demonstrate that cinnamaldehyde and synergistic combinations of C. verum + C. cassia EOs and C. cassia + C. loureiroi EOs have a high insecticidal efficacy against Aedes populations.

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“…Essential oils of Cinnamomum plants are widely used as promising antibacterial agents. Reports have indicated that the essential oils of C. camphora [3] and C. cassia [4,5] reverse antibiotic resistance and biofilm formation. Studies have also indicated that the C. zeylanicum (synonym of C. verum) has also found to be effective against multidrug resistant strains of clinical Shigella isolates [6].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition of Cinnamomum verum Leaf and Flower Essential Oils and Analysis of Their Antibacterial, Insecticidal, and Larvicidal Properties

Narayanankutty¹,

Kunnath

Alfarhan

et al. 2021

Molecules

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Cinnamomum verum is widely used in traditional medicines, and the different parts of the plant, such as bark, leaves, and flowers, are used for essential oil production. The present study compared the chemical composition of the essential oil of C. verum extracted from the leaves and flowers. In addition, efficacy of these essential oils against the two common pests Sitophilus oryzae and Callosobruchus maculatus was also evaluated. The results indicated the presence of cinnamaldehyde, eugenol, caryophyllene, and linalool in these essential oils, however, at different concentrations. The leaf essential oil was found to be 10–20% more effective as a fumigant against both the pests. Likewise, the leaf essential oil found to repel these pests even at lower concentrations than that of flower essential oil of C. verum. Besides, these essential oils were also effective in controlling the growth of various gram positive and gram negative microbial pathogens and possibly a safeguard for human health. On contrary, both the essential oils were found to be safe for the application on grains, as indicated by their germination potentials. It was also observed that these essential oils do not cause any significant toxicity to guppy fishes, thus confirming their ecological safety for use as a biopesticide.

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In vitro antimicrobial combinatory effect of Cinnamomum cassia essential oil with 8‐hydroxyquinoline against Staphylococcus aureus in liquid and vapour phase

Cited by 15 publications

References 32 publications

Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers

Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of Cassia timoriensis DC. Flowers

Improved adulticidal activity against Aedes aegypti (L.), and Aedes albopictus (Skuse), from synergy between Cinnamomum spp. essential oils

Chemical Composition of Cinnamomum verum Leaf and Flower Essential Oils and Analysis of Their Antibacterial, Insecticidal, and Larvicidal Properties

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