In vitro antimicrobial and anti-proliferative activities of plant extracts from Spathodea campanulata, Ficus bubu, and Carica papaya

Teinkela, Jean Emmanuel Mbosso; Nguedia, Jules Clément Assob; Meyer, Franck; Donfack, Erik V.; Ndjakou, Bruno Lenta; Ngouela, Silvère; Tsamo, Etienne; Adiogo, Dieudonné; Azebaze, Anatole Guy Blaise; Wintjens, René

doi:10.3109/13880209.2015.1103273

Cited by 25 publications

(12 citation statements)

References 67 publications

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“…The presence of tannins in the methanol leaf, stem and root extracts is in line with the report of Ghasemzadeh et al [35], that methanol(polar) was most effective in the extraction of phenolic compounds and still confirmed the use of most parts of the plant as antioxidants. Also the use of stem as anti diarrheal agent could be as a result of the presence of tannins in the methanol stem extract [10,6,33]. The absence of tannins in the n-hexane leaf, stem and root extracts and its presence in the methanol extracts is in line with the previous work done by Thavamoney et al [36] that the solubility of phenolic compounds increased with increasing solvent polarity, though water extract being the most polar solvent did not contain any phenolic compound.…”

Section: Resultsmentioning

confidence: 99%

“…S. campanulata flowers and bark are used to treat fever, convulsion, bacterial infections, HIV, poor blood circulation, gastrointestinal diseases, respiratory ailments, genitalurinary system disorders, filaria, gonorrhea, epilepsy and mental disorders. The flowers which are used as diuretic and anti-inflammatory; the leaves help in curing kidney diseases, urethra inflammations and animal poisoning [5,6]. Flowers of S. campanulata development is unique as inner whorls develop immersed in a fluid called water calyces and the fluid has been demonstrated to possess antimicrobial activities [7].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Phytochemical and Anti-microbial Studies of Leaf, Stem, Root of Spathodea companulata

Anarado

Umedum

et al. 2020

AJACR

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Aim: To compare the phytochemicals and anti bacterial activities of leaf, stem and root extracts of Spathodea companulata. Methodology: The leaf, stem and root of Spathodea companulata were collected, washed, air-dried, ground and each extracted with water, methanol, ethyl acetate and n-hexane. The extracts were analysed for the presence of phytochemicals. Antimicrobial analysis was also carried out on the extracts. Results: Glycosides were present in all the extracts except stem aqueous extract. Steroids were found absent in most of the extracts except methanol stem and n-hexane root extracts. Saponins were found in methanol, aqueous and ethyl acetate extracts of the root and stem, and in methanol and aqueous leaf extracts. Alkaloids were present in methanol and aqueous extracts of the leaf and root, and in ethyl acetate and n- hexane extracts of the stem. Quantity of Alkaloids and tannins were higher in leaf, while flavonoids and glycosides were higher in the stem and the roots contained higher amount of saponins. The extraction solvent polarities played important role in the type of metabolites extracted. The stem extracts were found to be most active against the seven test organisms used. Conclusion: More work should be done on the isolation and identification of compounds responsible for some of the pharmacological effects of the plant parts and the subsequent development of the compounds in formulation of drugs.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative Phytochemical and Anti-microbial Studies of Leaf, Stem, Root of Spathodea companulata

Anarado

Umedum

et al. 2020

AJACR

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“…The plates were cultivated at 37 °C, and the clear zone of growth inhibitions was observed. The microbroth dilution was performed in 96-well plate supplemented with Sabouraud dextrose broth [35]. Different concentrations of SSE and sasanquasaponin III (0, 0.0625, 0.125, 0.25, 0.5, 1, and 2 mg/mL) were obtained by a twofold serial dilution in the Sabouraud dextrose broth at a final volume of 50 µL, respectively.…”

Section: Methodsmentioning

confidence: 99%

Anticandidal Potential of Stem Bark Extract from Schima superba and the Identification of Its Major Anticandidal Compound

Wang²,

Wang

et al. 2019

Molecules

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Plant-derived extracts are a promising source of new drugs. Schima superba is traditionally used in China for heat clearing, detoxification, and treatment of furuncles. In this study, the anticandidal properties and mechanism of action of S. superba (SSE) were explored using a stem bark extract. SSE possessed high polyphenol and saponin contents of 256.6 ± 5.1 and 357.8 ± 31.5 µg/mg, respectively. A clear inhibition zone was observed for C. albicans growth through the disc diffusion method and the 50% inhibition of C. albicans by SSE was 415.2 µg/mL. Transcriptomic analysis in C. albicans treated with different doses of SSE was conducted through RNA-seq. Average values of 6068 genes and 20,842,500 clean reads were identified from each sample. Among these samples, 1680 and 1956 genes were differentially expressed genes (DEGs) from the SSE treatments of 0.2 and 0.4 mg/mL, respectively. C. albicans growth was inhibited by the changes in gene expression associated with the cell wall and membrane composition including the regulation of chitin degradation and ergosterol biosynthesis. This result could be reflected in the irregularly wrinkled morphology of the ruptured cell as revealed through SEM analysis. ESI-MS and NMR analyses revealed that the major compound purified from SSE was sasanquasaponin III and the 50% inhibition of C. albicans was 93.1 µg/mL. In summary, the traditional Chinese medicine S. superba can be applied as an anticandidal agent in complementary and alternative medicine.

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“…Giovina et al , found that ME of Salvia menthaefolia roots significantly inhibited the viability of the U87, T98G and DBTRG-05MG human GBM cell lines [ 188 ]. Similarly, the ME from leaves of another plant Ficus bubu (Moraceae family) also inhibited the proliferation of U373 GBM cells [ 189 ].…”

Section: Natural Products Effecting Gbm Cell Proliferation and Apoptomentioning

confidence: 99%

Natural products: a hope for glioblastoma patients

et al. 2018

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Glioblastoma (GBM) is one of the most aggressive malignant tumors with an overall dismal survival averaging one year despite multimodality therapeutic interventions including surgery, radiotherapy and concomitant and adjuvant chemotherapy. Few drugs are FDA approved for GBM, and the addition of temozolomide (TMZ) to standard therapy increases the median survival by only 2.5 months. Targeted therapy appeared promising in in vitro monolayer cultures, but disappointed in preclinical and clinical trials, partly due to the poor penetration of drugs through the blood brain barrier (BBB). Cancer stem cells (CSCs) have intrinsic resistance to initial chemoradiation therapy (CRT) and acquire further resistance via deregulation of many signaling pathways. Due to the failure of classical chemotherapies and targeted drugs, research efforts focusing on the use of less toxic agents have increased. Interestingly, multiple natural compounds have shown antitumor and apoptotic effects in TMZ resistant and p53 mutant GBM cell lines and also displayed synergistic effects with TMZ. In this review, we have summarized the current literature on natural products or product analogs used to modulate the BBB permeability, induce cell death, eradicate CSCs and sensitize GBM to CRT.

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In vitro antimicrobial and anti-proliferative activities of plant extracts from Spathodea campanulata, Ficus bubu, and Carica papaya

Abstract: These results indicate that effective drugs could be derived from the three studied plants.

Cited by 25 publications

References 67 publications

Comparative Phytochemical and Anti-microbial Studies of Leaf, Stem, Root of Spathodea companulata

Comparative Phytochemical and Anti-microbial Studies of Leaf, Stem, Root of Spathodea companulata

Anticandidal Potential of Stem Bark Extract from Schima superba and the Identification of Its Major Anticandidal Compound

Natural products: a hope for glioblastoma patients

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