<i>In vitro</i> antimicrobial activity of sodium hypochlorite and chlorhexidine against selected single‐species biofilms

Sena, Neylla Teixeira; Gomes, Brenda Paula Figueiredo de Almeida; Vianna, Morgana Eli; Berber, Vanessa Bellocchio; Zaia, Alexandre Augusto; Ferraz, Caio Cézar Randi; Souza-Filho, Francisco José de

doi:10.1111/j.1365-2591.2006.01161.x

Cited by 137 publications

(170 citation statements)

References 51 publications

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“…The 2.5% NaOCl group and 2% CHX group's CFU counts had no statistically significant difference, which suggests that 2% CHXs antifungal properties are comparable to 2.5% NaOCl's antifungal properties against the C. albicans biofilm. Sena et al found similar result that both NaOCl and CHX have antifungal properties but do not differ significantly, supporting the findings of this study [15].…”

Section: Discussionsupporting

confidence: 81%

Effects of a 980-Nm Diode Laser’s Activation of 2.5% Naocl and 2% Chlorhexidine Antifungal Irrigation Solutions on Candida Albicans Biofilms

2018

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Objective: Candida albicans is the most frequently found fungi in persistent root canal infections; it can form a biofilm and penetrate into dentinal tubules. Endodontic irrigants, such as 2.5% sodium hypochlorite (NaOCl) and 2% chlorhexidine (CHX), have antifungal properties, but limited penetration into dentinal tubules, which somewhat protects the C. albicans fungi. The use of a diode laser is an innovative approach in root canal treatments because it is able to penetrate deeper into the dentinal tubules. This study examined the effect of a 980-nm diode laser on the antifungal properties of 2.5% NaOCl and 2% CHX on C. albicans biofilms. Methods:The number of C. albicans colonies in the biofilms was recorded after irrigation using 2.5% NaOCl and 2% CHX. Then, the biofilms were radiated using a 980-nm diode laser.Results: Showed statistically significant differences between the use of the irrigants only and the use of the irrigants plus the diode laser treatment in the reduction of the C. albicans colonies in the biofilm. Conclusion:Diode laser is able to activate the antifungal properties of the 2.5% NaOCl and 2% CHX endodontic irrigants.

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Section: Discussionsupporting

confidence: 81%

Effects of a 980-Nm Diode Laser’s Activation of 2.5% Naocl and 2% Chlorhexidine Antifungal Irrigation Solutions on Candida Albicans Biofilms

2018

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“…It is by far the fungal species most commonly isolated from in- www.bjournal.com.br fected root canals, showing resistance to intracanal medication (3). The ability to form a biofilm and to invade dentinal tubules may help to explain the association with cases of persistent root canal infections (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens

Botelho

Nogueira

Bastos

et al. 2007

Braz J Med Biol Res

340

222

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Dental caries and periodontal disease are associated with oral pathogens. Several plant derivatives have been evaluated with respect to their antimicrobial effects against such pathogenic microorganisms. Lippia sidoides Cham (Verbenaceae), popularly known as "Alecrimpimenta" is a typical shrub commonly found in the Northeast of Brazil. Many plant species belonging to the genus Lippia yield very fragrant essential oils of potential economic value which are used by the industry for the commercial production of perfumes, creams, lotions, and deodorants. Since the leaves of L. sidoides are also extensively used in popular medicine for the treatment of skin wounds and cuts, the objective of the present study was to evaluate the composition and antimicrobial activity of L. sidoides essential oil. The essential oil was obtained by hydro-distillation and analyzed by GC-MS. Twelve compounds were characterized, having as major constituents thymol (56.7%) and carvacrol (16.7%). The antimicrobial activity of the oil and the major components was tested against cariogenic bacterial species of the genus Streptococcus as well as Candida albicans using the broth dilution and disk diffusion assays. The essential oil and its major components thymol and carvacrol exhibited potent antimicrobial activity against the organisms tested with minimum inhibitory concentrations ranging from 0.625 to 10.0 mg/mL. The most sensitive microorganisms were C. albicans and Streptococcus mutans. The essential oil of L. sidoides and its major components exert promising antimicrobial effects against oral pathogens and suggest its likely usefulness to combat oral microbial growth.

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“…This is a result of the physical limitations of endodontic instruments and the short time irrigants remain in the root canal during instrumentation/ irrigation procedures. Although sodium hypochlorite (NaOCl) has excellent antimicrobial activity against most putative endodontic pathogens (5), this irrigant is allowed to act within the root canal system only for a short period. As chemomechanical preparation procedures have been expedited after introduction of rotary instruments, the permanence of NaOCl within the root canal has been even shortened.…”

Section: Introductionmentioning

confidence: 99%

Influence of serum and necrotic soft tissue on the antimicrobial effects of intracanal medicaments

et al. 2010

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The purpose of this study was to investigate the influence of serum and necrotic soft tissue on the antimicrobial activity of intracanal medicaments. The medicaments tested were: calcium hydroxyde/glycerin paste, calcium hydroxide/chlorhexidine paste, calcium hydroxide/camphorated paramonochlorophenol/glycerin paste, and chlorhexidine/zinc oxide paste. Survival of Enterococcus faecalis and Candida albicans exposed to the medicaments tested in the presence or absence of serum or necrotic tissue was monitored in three in vitro experiments where samples for culturing were taken at different time periods. The overall results demonstrated that the antimicrobial activity of all intracanal medicaments tested was slowed down in the presence of necrotic tissue. Calcium hydroxide pastes in glycerin or chlorhexidine were significantly affected by serum. Of the medicaments tested in this study, the least affected was the calcium hydroxide/camphorated paramonochlorophenol/glycerin paste.

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In vitro antimicrobial activity of sodium hypochlorite and chlorhexidine against selected single‐species biofilms

Abstract: Mechanical agitation improved the antimicrobial properties of the chemical substances tested using a biofilm model, favouring the agents in liquid presentation, especially 5.25% NaOCl and 2% chlorhexidine.

Cited by 137 publications

References 51 publications

Effects of a 980-Nm Diode Laser’s Activation of 2.5% Naocl and 2% Chlorhexidine Antifungal Irrigation Solutions on Candida Albicans Biofilms

Effects of a 980-Nm Diode Laser’s Activation of 2.5% Naocl and 2% Chlorhexidine Antifungal Irrigation Solutions on Candida Albicans Biofilms

Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens

Influence of serum and necrotic soft tissue on the antimicrobial effects of intracanal medicaments

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