In VitroAntifungal Activity of Sertaconazole Nitrate Against Recent Isolates of Onychomycosis Causative Agents

Sertaconazole Antifungal Profile Determined by a Microdilution Method versus Nine Topical Substances against Dermatophyte Fungi

“…The susceptibility profile of dermatophyte fungi seems to be genus/species-dependent as previously described for BFZ, STZ and TRB, but with the use of nonstandardized culture media [10,11,21,22,23]. Our data suggest that the antifungal concentration is important because different inhibition percentages are obtained for inocula and isolates, which in some cases are not related to an increase in the concentration.…”

“…Before the trial, the isolates were reidentified by biochemical and morphological tests in culture media and also via macroscopical microscopical observations [15]. The quality control strains Candida krusei ATCC 6258 and C. parapsilosis ATCC 22019 and the reference strains Aspergillus fumigatus NCPF 7100 and A. fumigatus NCPF 7099 were included as in previous research studies on standardization and adaptation to the requirements of dermatophyte fungi [6,7,8,9,10,11,12,13]. …”

“…Drugs were used as pure substances from Sigma-Aldrich and, in the case of STZ, the substance provided by the manufacturer was used (Grupo Ferrer, Barcelona, Spain). The standardized methods include the special requirements of dermatophyte fungi and were studied by several authors, enabling the assessment of antifungal activity based on the determination of minimum inhibitory concentrations (MIC) [5,6,7,8,9,10,11,12,13]. These requirements were related to incubation temperature (28°C) and prolonged incubation times from 2–3 days to 4–10 days or, alternatively, until some kind of fungal development was detected.…”

Comparison of efficacy, safety and cost-effectiveness of clotrimazole 1% cream and sertaconazole 2% cream in patients suffering from of mild to moderate tinea corporis, attending tertiary care hospital out-patient department: a randomized, open-labeled, comparative, parallel group trial

“…In addition, anti-inflammatory properties have been described by reducing cytokine secretion from activated lymphocytes, histamine release from mast cells and release of PGE 2, all of which control the inflammatory component of dermatophytosis. [19][20][21] PGA showed that complete clinical cure rate i.e. excellent response at the end of "treatment phase" was highest with topical sertaconazole 2% cream (93.75) as compared to clotrimazole 1% cream (74.47%).…”

Sertaconazole Nitrate Shows Fungicidal and Fungistatic Activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, Causative Agents of Tinea Pedis

“…imidazole nitrate, against dermatophytes has been previously described (3)(4)(5)(6)10), but the only available fungicidal data against dermatophytes are limited to two strains of T. mentagrophytes (13). Sertaconazole has previously been shown to exhibit both fungistatic and fungicidal activities against several Candida species and other yeasts (2, 7-9, 11, 13, 17-20).…”