Comparison of efficacy, safety and cost-effectiveness of clotrimazole 1% cream and sertaconazole 2% cream in patients suffering from of mild to moderate tinea corporis, attending tertiary care hospital out-patient department: a randomized, open-labeled, comparative, parallel group trial

Khan, Huma S.; Dudhgaonkar, Sujata; Bende, Mats; Wankhede, Sumit S.

doi:10.5455/2319-2003.ijbcp20150214

Cited by 5 publications

(4 citation statements)

References 11 publications

(12 reference statements)

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“…Moreover, as per the studies conducted by Khan et al, Shivamurthy et al, and Satish et al; topical sertaconazole has shown better therapeutic response in comparison with topical clotrimazole in other types of tinea infections such as tinea corporis. [9][10][11] In this manner, the study results of this study is quite similar to the previously conducted studies on comparison of topical antifungals in other tinea infections.…”

Section: Discussionsupporting

confidence: 86%

Prospective study on comparison of efficacy of topical anti-fungal agents: clotrimazole 1% and sertaconazole 2% in treatment of tinea cruris

Lakhani¹,

Joshi²,

Kumbhani³

et al. 2019

Int J Res Dermatol

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Background: Tinea cruris is a common superficial dermatophytic infection of the skin occurring in 20-25% population worldwide. The various types of antifungal agents are available for topical use in treatment of tinea cruris. Clotrimazole is conventional imidazole antifungal drug whereas sertaconazole is newer imidazole antifungal claimed to be superior to clotrimazole in tinea infection. The aim of the study was to determine and compare the efficacy of potent topical azole agents 1% clotrimazole and 2% sertaconazole in patients diagnosed with tinea cruris attending out-patient department of skin and VD of tertiary care hospital in Vadodara.Methods: A total of 71 patients diagnosed with tinea cruris were divided into two groups. Group A received topical clotrimazole (1% cream), and Group B received topical sertaconazole (2% cream). Outcome parameters such as erythema, scaling, itching, margins of lesions and size of lesions were noted atthe time of hospital visit, by 3rd week and by 6th week for the assessment of efficacy. The statistical test used was independent student t-test and software used was SPSS 20.0.Results: At the end of follow-up phase, both the drugs were found to be effective with no recurrence or relapse of tinea cruris. However, compared to clotrimazole 1% cream, sertaconazole 2% cream had statistically significant rapid relief in terms of reduction in clinical parameters such as erythema (p<0.001), scaling (p<0.001), itching (p<0.001), size of lesion (p<0.001) and margin of lesion (p<0.011).Conclusions: Topical sertaconazole 2% cream was found to be highly efficacious and superior to clotrimazole 1% cream in improvement of clinical parameters of tinea cruris.

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Section: Discussionsupporting

confidence: 86%

Prospective study on comparison of efficacy of topical anti-fungal agents: clotrimazole 1% and sertaconazole 2% in treatment of tinea cruris

Lakhani¹,

Joshi²,

Kumbhani³

et al. 2019

Int J Res Dermatol

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“…On doing cost-effective analysis, treatment modality having low cost-effective ratio (CER) is considered to be superior to the other drug. [ 20 ] It was observed in our study CER was high for clotrimazole drug than luliconazole at the end of two weeks as the cure rate was more in luliconazole group. There is no cost-effectiveness study available on head on comparison between these two study drugs.…”

Section: Discussionmentioning

confidence: 59%

Efficacy, safety, and cost evaluation of the topical luliconazole therapy versus topical clotrimazole therapy in patients with localized dermatophytosis in a tertiary care hospital: An observational study

Kaur

Gupta

Mahajan

et al. 2020

Int J App Basic Med Res

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Background: Dermatophytosis is a superficial fungal infection that has high affinity for keratinized tissues of the body. The treatment of localized dermatophytosis is a major concern for the dermatologist especially in tropical countries like India. Various topical antifungals are available for the treatment of localized uncomplicated dermatophytosis. Luliconazole is an azole antifungal available that has potent activity against dermatophytes. Objectives: The objective of this study was to compare two treatment modalities for the treatment of localized dermatophytosis in terms of efficacy, safety, and cost evaluation. Materials and Methods: This was a prospective and observational study carried out for 6 months and included 200 patients (luliconazole group [ n = 94] and clotrimazole group [ n = 106]). Patients were followed up for 2, 4, and 6 weeks. Outcome parameters such as pruritis, erythema, scaling, vesiculations, and global assessment score were noted at 2, 4, and 6 weeks for the assessment of efficacy. The statistical analysis was done using Chi-square and Student's t -test. Results: Luliconazole and clotrimazole showed 56.38% and 23.58% cure rate at the end of two weeks respectively ( P < 0.05). At the end of treatment, the cure rates were 98.93% and 95.28% in luliconazole and clotrimazole, respectively ( P > 0.005). Both the drugs were equally safe. On cost-effective analysis, luliconazole was found to be more cost-effective than clotrimazole at the end of 2 weeks. Conclusion: Therapeutic efficacy of luliconazole was more as significant proportion of patients achieved complete clearance of lesions at faster rate within 2 weeks with convenient once daily application.

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“…The rate of topical fungal infections is progressively raised due to increase in the number of immunocompromised patients, and increased use of community swimming pools. 2 Recent occurance of dermatophytic infections is due to unhygienic conditions, swimming pools etc., 3 The incidence of fungal infections is increasing due to widespread use of antimicrobials and immunosuppressants and due to immunecompromised states such as diabetes mellitus, HIV-AIDS etc. 3,4 Several species of fungi causes ringworm, most commonly include trichophyton, microspores and epidermophyton.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Safety, Efficacy, and Cost-Effectiveness of Miconazole 2% Versus Sertaconazole 2% in the Treatment of TineaCorporis: A Randomized Control Trial

Narayana¹,

Somasekhar²,

Kc³

et al. 2022

Int J Life Sci Pharm Res

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Tineacorporis is a dermatophytic infection of the body, which involves the keratin layer of the skin. These lesions are present as an annular plaque with an advancing border along with central clearing. Miconazole, a topical antifungal drug and has good efficacy, in anti dermatophyte. Sertaconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethylation via the inhibition of the enzyme cytochrome P450 14α-demethylase.It is claimed to be superior to other old topical imidazoles in tineacorporis. .The present study was aimed to compare the safety, efficacy and cost-effectiveness of topical antifungals, where we have compared Miconazole and Sertaconazole 2% creams in the treatment of fungal infection caused by tineacorporis, by assessing the ADR’s and therapeutic outcomes, using comparative, unicentered, randomized, non-blinded trial with 2 parallel treatment arms of one-month duration. In this study 106 patients were randomly assigned into 2 groups of Miconazole 2% cream and Sertaconazole 2% with 54 and 52 patients in each group respectively. Measurement is carried out at baseline, 1st, 2nd and 3rd follow-up for desired effects like itching, erythema, pain and lesions, physician’s global assessment (PGA), safety and cost-effectiveness. The results showed that sertaconazole 2% cream is efficacious and superior to Miconazole 2% cream in the improvement of clinical parameters and PGA. At the end of the follow-up phase, both groups of drugs are effective and well-tolerated in patients with no recurrence of tineacorporis. Effectiveness of SSertaconazole is early and superior with minor side effects. However, Miconazole is cost effective and safe.

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Comparison of efficacy, safety and cost-effectiveness of clotrimazole 1% cream and sertaconazole 2% cream in patients suffering from of mild to moderate tinea corporis, attending tertiary care hospital out-patient department: a randomized, open-labeled, comparative, parallel group trial

Cited by 5 publications

References 11 publications

Prospective study on comparison of efficacy of topical anti-fungal agents: clotrimazole 1% and sertaconazole 2% in treatment of tinea cruris

Prospective study on comparison of efficacy of topical anti-fungal agents: clotrimazole 1% and sertaconazole 2% in treatment of tinea cruris

Efficacy, safety, and cost evaluation of the topical luliconazole therapy versus topical clotrimazole therapy in patients with localized dermatophytosis in a tertiary care hospital: An observational study

Comparison of Safety, Efficacy, and Cost-Effectiveness of Miconazole 2% Versus Sertaconazole 2% in the Treatment of TineaCorporis: A Randomized Control Trial

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