In vitro antibacterial and antifungal assay of poly‐(ethylene oxamide‐N,N′‐diacetate) and its polymer–metal complexes

Ahamad, Tansir; Parveen, Shadma; Nishat, Nahid

doi:10.1002/aoc.1331

Cited by 20 publications

(10 citation statements)

References 28 publications

(9 reference statements)

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“…This effect increases the lipophilic character of the metal ion, which favors the permeation through the lipoid layers of the bacterial membranes. The factors, such as solubility, conductivity, dipole moment, and cell permeability, may also contribute for the increased activity of the complexes …”

Section: Resultsmentioning

confidence: 99%

Thiazole‐Based Novel Terpolymer Ligand and Its Transition Metal Complexes: Thermal and Biological Studies

Ahamed¹,

Burkanudeen²

2013

Adv Polym Technol

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A new terpolymer ligand involving 2-amino-6-nitro-benzothiazole, melamine, and formaldehyde (BMF) has been synthesized in the presence of dimethyl formamide medium. The BMF ligand was characterized by elemental analysis and various spectral techniques like Fourier transform infrared (FTIR) spectroscopy, ultraviolet (UV)-visible spectroscopy, and 1 H & 13 C nuclear magnetic resonance (NMR) spectroscopy to elucidate the structure and properties of the terpolymer ligand. The BMF metal complexes were prepared using the BMF ligand with some transition metal ions, such as Cu 2+ , Ni 2+ , and Zn 2+ ions, in the presence of ethanol medium. The prepared complexes have been characterized by elemental analysis and FTIR, electronic, electron spin resonance, and 1 H & 13 C NMR spectral studies. The molecular weight of the BMF ligand and its metal complexes was determined by gel permeation chromatography. The surface features and crystalline behavior of the ligand and its complexes were analyzed by scanning electron microscope (SEM) and X-ray diffraction (XRD) methods. Thermal stability of the ligand and its metal complexes was studied by thermogravimetric analysis (TGA). Kinetic parameters such as activation energyand order of reaction (n), and thermodynamic parameters namely entropy change, free energy change, apparent entropy, and frequency factor were calculated using Freeman-Carroll, Sharp-Wentworth, and Phadnis-Deshpande (PD) methods. Thermal degradation model of the terpolymer ligand and its metal complexes was also proposed using the PD method. The antibacterial activities of the BMF ligand and its metal complexes were checked against chosen microbes such as Shigella sonnei, Escherichia coli, Klebsiella species, Staphylococcus aureus, Bacillus subtilis, and Salmonella typhimurium. C

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Section: Resultsmentioning

confidence: 99%

Thiazole‐Based Novel Terpolymer Ligand and Its Transition Metal Complexes: Thermal and Biological Studies

Ahamed¹,

Burkanudeen²

2013

Adv Polym Technol

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“…In vitro antibacterial and antifungal activities of poly(ethylene oxamide‐ N , N ‐diacetate) and its polymer–metal complexes were investigated. The antimicrobial activity of Cu(II)‐coordinated polymer was found to be greater than that of other metal‐coordinated polymers due to the higher stability constant of the Cu(II) ion . A Schiff base ligand was prepared via condensation of pyridine‐2,6‐dicarboxaldehyde with 2‐aminopyridine and transition metal complexes were also prepared.…”

Section: Introductionmentioning

confidence: 99%

“…The antimicrobial activity of Cu(II)-coordinated polymer was found to be greater than that of other metal-coordinated polymers due to the higher stability constant of the Cu(II) ion. [8] A Schiff base ligand was prepared via condensation of pyridine-2,6-dicarboxaldehyde with 2-aminopyridine and transition metal complexes were also prepared. The synthesized ligand, in comparison with its metal complexes, was also screened for its antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Polymer‐supported metal complexes as antibacterial agents: synthesis, characterization and thermal degradation kinetics

Azarudeen¹,

Ahamed²,

Prabu

et al. 2014

Applied Organom Chemis

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Polymeric metal complexes were prepared using a synthesized novel terpolymer ligand involving anthranilic acid–o‐toluidine–formaldehyde by a polycondensation technique. The synthesized ligand and its metal complexes were characterized using elemental analysis and molar conductivity measurements, and FT‐IR, electronic, electron spin resonance and NMR (1H and 13C) spectral methods. The surface morphology and the nature of the synthesized compounds were examined using scanning electron microscopy and X‐ray diffraction. The thermal stabilities of the ligand and its metal complexes were determined using thermogravimetric analysis (TGA). From the TGA results, various kinetic parameters, i.e. activation energy and order of reaction, and thermodynamic parameters, i.e. entropy change, apparent entropy, frequency factor and free energy change, were determined using the Freeman–Carroll and Sharp–Wentworth methods. In addition, a thermal degradation model was also proposed using the Phadnis–Deshpande method. The thermal stability of the ligand and its metal complexes was found to be appreciably high; in particular, the ligand showed very high stability compared to its metal complexes due to intramolecular hydrogen bonding. Furthermore, the synthesized compounds were subjected to in vitro antibacterial studies with various microorganisms. The results of the studies confirmed that the compounds showed better antibacterial results than a standard antibacterial drug. Copyright © 2014 John Wiley & Sons, Ltd.

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“…A new polyester poly(ethylene oxamide-N,N-diacetate) containing glycine moiety was synthesized and its metal complexes were prepared. According to their reports, these polymers can be effectively used as anti-fungal and anti-fouling coating materials in lifesaving medical devices and the bottoms of ships [13]. Polychelates of Cu(II), Co(II), and Ni(II) chlorides with the poly(acrylic acid-co-maleic acid) copolymer in aqueous medium [14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral, Morphology, Thermal Degradation Kinetics and Antibacterial Studies of Terpolymer Metal Complexes

Azarudeen¹,

Burkanudeen²

2011

J Inorg Organomet Polym

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Terpolymer metal complexes involving transition metal ions such as Cu(II), Mn(II) and Zn(II) were prepared using a terpolymer ligand derived from anthranilic acid-phenyl hydrazine-formaldehyde (APHF). The terpolymer ligand and its metal complexes were intended to spectral characterizations viz. FTIR, electronic, ESR, 1 H NMR and 13 C NMR to elucidate the structural confirmations. The number, weight, and size average molecular weights of the terpolymer ligand were determined by gel permeation chromatography (GPC). The empirical formula of the repeating unit for both the terpolymer ligand and its metal complexes was clearly justified by elemental analysis. The thermal stability of the ligand and its metal complexes was established by thermogravimetric analysis (TGA). On basis of the TGA data, the kinetic and thermodynamic parameters such as activation energy (E a ), order of reaction (n), entropy change (DS), apparent entropy (S*), frequency factor (Z) and free energy change (DF) were calculated using Freeman-Carroll and SharpWentworth methods. Further the degradation mechanism for the thermal decomposition was also identified from Phadnis-Desphande method. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis were used to establish the surface morphology and nature of the terpolymer ligand and its metal complexes. In addition, the terpolymer ligand and its metal complexes were screened against the growth of few bacteria and their inhibitions were measured and reported.

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In vitro antibacterial and antifungal assay of poly‐(ethylene oxamide‐N,N′‐diacetate) and its polymer–metal complexes

Cited by 20 publications

References 28 publications

Thiazole‐Based Novel Terpolymer Ligand and Its Transition Metal Complexes: Thermal and Biological Studies

Thiazole‐Based Novel Terpolymer Ligand and Its Transition Metal Complexes: Thermal and Biological Studies

Polymer‐supported metal complexes as antibacterial agents: synthesis, characterization and thermal degradation kinetics

Synthesis, Spectral, Morphology, Thermal Degradation Kinetics and Antibacterial Studies of Terpolymer Metal Complexes

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