<i>In vitro</i> Antibacterial Activity of Doripenem against Gram-Negative Blood Isolates in a Korean Tertiary Care Center

Choi, Seong-Ho; Ahn, Mi Young; Chung, Jin-Won; Lee, Mi-Kyung

doi:10.3947/ic.2015.47.3.175

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…From our point of view, local susceptibility data could be precious. Recent data from an Asia-Pacific surveillance study and a Korean tertiary care center indicate that doripenem has excellent in vitro activity against Enterobacteriaceae, while the MIC values of doripenem for nonfermentative Gramnegative pathogens (Pseudomonas aeruginosa and Acinetobacter baumannii) were worrisome (34,35). Therefore, we suggest that empirical dosing of doripenem without determination of an MIC would result in treatment failure.…”

Section: Discussionmentioning

confidence: 88%

Population Pharmacokinetic Analysis of Doripenem after Intravenous Infusion in Korean Patients with Acute Infections

Lee

Kim

Jin

et al. 2017

Antimicrob Agents Chemother

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We investigated the population pharmacokinetics (PK) of doripenem in Korean patients with acute infections and determined an appropriate dosing regimen using a Monte Carlo simulation for predicting pharmacodynamics (PD). Patients (n ϭ 37) with a creatinine clearance (CL CR ) of 20 to 50 ml/min or Ͼ50 ml/min who received a 250-mg or 500-mg dose of doripenem over the course of 1 h every 8 h, respectively, were included in this study. Blood samples were taken predosing and 0 h, 0.5 h, and 4 to 6 h after the fourth infusion. A nonlinear mixed-effect modeling tool was used for the PK analysis and pharmacodynamic simulation; doripenem PK were well described by a one-compartment model. The population mean values of the body weight (WT)-normalized clearance (CL/WT) and the body weight-normalized volume of distribution (V/WT) were 0.109 liter/h/kg of body weight (relative standard error, 9.197%) and 0.280 liter/kg (relative standard error, 9.56%), respectively. Doripenem CL was significantly influenced by CL CR . The proposed equation to estimate doripenem CL in Korean patients was CL/WT ϭ 0.109 ϫ WT ϫ (CL CR /57) 0.688 , where CL/WT is in liters per hour per kilogram. CL in Korean patients was expected to be lower than that in Caucasian patients, regardless of renal function. The Monte Carlo simulation showed that 90% attainment of target PK/PD magnitudes could be achieved with the usual dosing regimens when the MIC was Յ1 mg/liter. However, prolonged infusions (4 h) should be considered, especially when patients have augmented renal function and for patients infected with pathogens with a high MIC. Our results provide an individualized doripenem dosing regimen for patients with various renal functions and for patients infected with bacteria with decreased susceptibility.

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Section: Discussionmentioning

confidence: 88%

Population Pharmacokinetic Analysis of Doripenem after Intravenous Infusion in Korean Patients with Acute Infections

Lee

Kim

Jin

et al. 2017

Antimicrob Agents Chemother

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“…-0%) to doripenem. (16) The activity of all the three carbapenems against Pseudomonas spp. was comparable to each other.…”

Section: Discussionmentioning

confidence: 99%

Comparative Activity of Doripenem, Imipenem and Meropenem Against Gram Negative Pathogens: A Preliminary Study

Alexander¹,

Oberoi²,

Kumar³

2016

jemds

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BACKGROUND AND OBJECTIVEDoripenem is a new parenteral carbapenems, which has beta-lactamase stability and is not inactivated by renal dehydropeptidases. Doripenem has a spectrum of activity similar to imipenem and ertapenem against Gram-positive cocci and similar to meropenem against Gram-negative pathogens. In this study, we summarize the activity of doripenem against Gram negative bacilli in comparison with other carbapenems (Imipenem, meropenem) and select group of antimicrobial drugs by disk diffusion.

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“…The prevalence of carbapenem-producing Enterobacteriaceae (CPE) is high in humans with advanced age, primarily, due to their frequent visits to hospitals, long-term stay in health care facilities, tertiary care hospitals, and teaching hospitals [ 25 , 26 , 27 , 28 , 29 , 30 ]. Hospital stay represents a particularly high risk to be colonize or in developing an infection with a CRE.…”

Section: Carbapenemases-producing Enterobacteriaceae mentioning

confidence: 99%

Molecular Epidemiology of Carbapenemases in Enterobacteriales from Humans, Animals, Food and the Environment

et al. 2020

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The Enterobacteriales order consists of seven families including Enterobacteriaceae, Erwiniaceae, Pectobacteriaceae, Yersiniaceae, Hafniaceae, Morganellaceae, and Budviciaceae and 60 genera encompassing over 250 species. The Enterobacteriaceae is currently considered as the most taxonomically diverse among all seven recognized families. The emergence of carbapenem resistance (CR) in Enterobacteriaceae caused by hydrolytic enzymes called carbapenemases has become a major concern worldwide. Carbapenem-resistant Enterobacteriaceae (CRE) isolates have been reported not only in nosocomial and community-acquired pathogens but also in food-producing animals, companion animals, and the environment. The reported carbapenemases in Enterobacteriaceae from different sources belong to the Ambler class A (blaKPC), class B (blaIMP, blaVIM, blaNDM), and class D (blaOXA-48) β-lactamases. The carbapenem encoding genes are often located on plasmids or associated with various mobile genetic elements (MGEs) like transposons and integrons, which contribute significantly to their spread. These genes are most of the time associated with other antimicrobial resistance genes such as other β-lactamases, as well as aminoglycosides and fluoroquinolones resistance genes leading to multidrug resistance phenotypes. Control strategies to prevent infections due to CRE and their dissemination in human, animal and food have become necessary. Several factors involved in the emergence of CRE have been described. This review mainly focuses on the molecular epidemiology of carbapenemases in members of Enterobacteriaceae family from humans, animals, food and the environment.

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In vitro Antibacterial Activity of Doripenem against Gram-Negative Blood Isolates in a Korean Tertiary Care Center

Cited by 4 publications

References 18 publications

Population Pharmacokinetic Analysis of Doripenem after Intravenous Infusion in Korean Patients with Acute Infections

Population Pharmacokinetic Analysis of Doripenem after Intravenous Infusion in Korean Patients with Acute Infections

Comparative Activity of Doripenem, Imipenem and Meropenem Against Gram Negative Pathogens: A Preliminary Study

Molecular Epidemiology of Carbapenemases in Enterobacteriales from Humans, Animals, Food and the Environment

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