Comparative Activity of Doripenem, Imipenem and Meropenem Against Gram Negative Pathogens: A Preliminary Study

Abstract

BACKGROUND AND OBJECTIVEDoripenem is a new parenteral carbapenems, which has beta-lactamase stability and is not inactivated by renal dehydropeptidases. Doripenem has a spectrum of activity similar to imipenem and ertapenem against Gram-positive cocci and similar to meropenem against Gram-negative pathogens. In this study, we summarize the activity of doripenem against Gram negative bacilli in comparison with other carbapenems (Imipenem, meropenem) and select group of antimicrobial drugs by disk diffusion.