<i>In Vitro</i> Anti‐AChE, Anti‐BuChE, and Antioxidant Activity of 12 Extracts of <i>Eleutherococcus</i> Species

Załuski, Daniel; Kuźniewski, Rafał

doi:10.1155/2016/4135135

Cited by 15 publications

(11 citation statements)

References 21 publications

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“…All listed compounds contain in their structure the chemical groups that can interact with AChE and BuChE and inhibit them. They can act as chelators of metal ions or next possible mechanism is the interactions between active groups of inhibitors and amino acids of the active site of enzymes (Załuski & Kuźniewski, ). However, other specific studies on the mechanism of inhibition isolated compounds, their bioavailability, digestibility should to be conducted.…”

Section: Resultsmentioning

confidence: 99%

Changes of peach juices during the shelf‐life and their in vitro effect on glycolipid digestion and neurotransmitter metabolism

Nowicka

Teleszko

Wojdyło

2019

Int J of Food Sci Tech

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In this study, the polyphenols content, a-amylase, a-glucosidase and cholinesterase-inhibiting activities of cloudy peach (Prunus persica) juices, were measured immediately after thermal treatment and after storage (6 months at 4 and 30°C). The study showed that some cultivars were more useable for industry than others. Due to the high content of polyphenols and a high ability to inhibit enzymes linked to type 2 diabetes and Alzheimer's disease, noteworthy are the juices obtained from 'Redheaven early' and 'Redheaven' cultivars. The content of total phenolics ranged from 1109.7 to 390.7 mg/L of juice, and the dominant fraction was polymeric procyanidins. Following 6 months of storage a significant change was observed in the content of polyphenols, especially flavonols and anthocyanins. The data compiled from the conducted study indicate that peach juice could be useful for the juice industry as a promising source of bioactive compounds. Characteristics of peach juices during storage P. Nowicka et al. 1866 6 m at 30°C Paraguayo 17.41 AE 0.95b 254.54 AE 5.62e 2.12 AE 0.11e 271.95 AE 6.57e 22.16 AE 1.07d 26.84 AE 1.56c 0.00 AE 0.00d 0.57 AE 0.03 2.41 AE 0.18a 51.98 AE 2.84c Candor 15.96 AE 0.05c 329.26 AE 3.99d 2.49 AE 0.09c 345.22 AE 4.04d 41.50 AE 3.93b 22.81 AE 0.83d 0.70 AE 0.03c 1.94 AE 0.21 1.93 AE 0.06b 68.88 AE 5.06b Harna s 15.55 AE 0.99c 447.89 AE 8.70c 2.93 AE 0.04a 463.44 AE 9.69c 33.71 AE 0.76c 18.42 AE 1.10e 0.94 AE 0.05b 1.00 AE 0.09 1.55 AE 0.01d 55.62 AE 2.01c Characteristics of peach juices during storage P. Nowicka et al. PcJ, peach juice. Mean values followed by different letters are statistically different at P ≤ 0.05. † Values are means of three repetitions. ‡ The percentage values means changes of enzyme inhibition during storage time compared to the products immediately after processing.Italic values are means of average inhibitory activities toward enzymes, within selected qualitative characteristics (stability of selected cultivars and the effect of storage time).Characteristics of peach juices during storage P. Nowicka et al. 1872 Characteristics of peach juices during storage P. Nowicka et al.

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Section: Resultsmentioning

confidence: 99%

Changes of peach juices during the shelf‐life and their in vitro effect on glycolipid digestion and neurotransmitter metabolism

Nowicka

Teleszko

Wojdyło

2019

Int J of Food Sci Tech

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“…The previous studies of Załuski et al [ 30 ] on the anti-AChE activity of the 75% ethanol extracts from the roots of Eleutherococcus spp. have shown 50% inhibition for the extract concentration in the range of 300-1750 μ g/mL.…”

Section: Resultsmentioning

confidence: 99%

EleutherococcusSpecies Cultivated in Europe: A New Source of Compounds with Antiacetylcholinesterase, Antihyaluronidase, Anti-DPPH, and Cytotoxic Activities

Adamczyk

Olech

Abramek

et al. 2019

Oxidative Medicine and Cellular Longevity

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Secondary metabolites of the roots of Eleutherococcus spp. cultivated in Poland, or the bioactivity, are not fully known. The 75% methanol extracts of five Eleutherococcus spp. (E. senticosus, E. divaricatus, E. sessiliflorus, E. gracilistylus, and E. henryi) were examined for the content of polyphenols and phenolic acids as well as for antiacetylcholinesterase, antihyaluronidase, anti-DPPH∗, and cytotoxic activities. The richest in polyphenols were the roots of E. henryi (10.4 mg/g DW), while in flavonoids the roots of E. divaricatus (6.5 mg/g DW). The richest in phenolic acids occurred the roots of E. henryi [protocatechuic acid (1865 μg/g DE), caffeic acid (244 μg/g DE), and p-coumaric and ferulic acids (55 μg/g DE)]. The highest inhibition of AChE was observed for E. gracilistylus and E. sessiliflorus (32%), at the concentration of 100 μg/0.19 mL of the reaction mixture, while that of Hyal for the roots of E. henryi (40.7%), at the concentration of 100 μg/0.16 mL of the reaction mixture. Among five species tested, the E. henryi extract exhibited the strongest HL-60 cell line growth’s inhibition (IC50 270 μg/mL). The extracts reduced DPPH∗ in a time-dependent mode, at the concentration of 0.8 mg/mL. After 90 min from 14.7 to 26.2%, DPPH∗was reduced. A phytochemical composition and activity of the Eleutherococcus species, cultivated in Poland, are still under research; however, on the basis of the results obtained, it may be concluded that they may become a source of phytochemicals and be useful for Europe’s citizens.

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“…TLC and HPTLC were also employed for the separation of the mixture and isolation of the bioactive compounds using 3). Leaf extract contained more flavonoids and phenolic compounds in the F2 fraction [32] .…”

Section: Table 4: the Identified Components Present In Gc-ms Analysismentioning

confidence: 93%

Anticholinesterase Activity and Mass Spectral Analysis of Olea dioica Roxb., An in vitro Study

Pratap¹,

Rather²,

Shantaram³

2020

pharmaceutical-sciences

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In Vitro Anti‐AChE, Anti‐BuChE, and Antioxidant Activity of 12 Extracts of Eleutherococcus Species

Cited by 15 publications

References 21 publications

Changes of peach juices during the shelf‐life and their in vitro effect on glycolipid digestion and neurotransmitter metabolism

Changes of peach juices during the shelf‐life and their in vitro effect on glycolipid digestion and neurotransmitter metabolism

EleutherococcusSpecies Cultivated in Europe: A New Source of Compounds with Antiacetylcholinesterase, Antihyaluronidase, Anti-DPPH, and Cytotoxic Activities

Anticholinesterase Activity and Mass Spectral Analysis of Olea dioica Roxb., An in vitro Study

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