“…Here, the goal is to extrapolate intestinal availability in humans from the most relevant animal model, or if necessary directly from human intestinal metabolism data that has been generated in vitro (22,23,27,29). The latter consideration is particularly important given that patterns of phase I and II DME expression in the intestine can differ markedly between species (63,79,87). Although research into IVIVE of intestinal metabolism data is evolving (88), it is still some way behind the established models used for the liver (22,23,28,29).…”