<i>In Vitro</i> and <i>In Vivo</i> Characterization of the New Analgesic Combination Beta‐Caryophyllene and Docosahexaenoic Acid

Fiorenzani, Paolo; Lamponi, Stefania; Magnani, Agnese; Ceccarelli, Ilaria; Aloisi, Anna Maria

doi:10.1155/2014/596312

Cited by 24 publications

(25 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this purpose, Fiorenzani et al. studied the antinociceptive activity of BCP in mixture with docosahexaenoic acid (DHA). DHA is a member of omega‐3 polyunsaturated fatty acids (PUFAs) and well‐known anti‐inflammatory mediator .…”

Section: Bcp(o) As Analgesic Agentsmentioning

confidence: 99%

“…One can hypothesize that better analgesic effects may be obtained when BCP is used in combination with other natural agent(s) of desired properties. For this purpose, Fiorenzani et al [61] studied the antinociceptive activity of BCP in mixture with docosahexaenoic acid (DHA). DHA is a member of omega-3 polyunsaturated fatty acids (PUFAs) and well-known anti-inflammatory mediator [62].…”

Section: Bcp(o)asanalgesicagentsmentioning

confidence: 99%

See 1 more Smart Citation

β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties

et al. 2016

View full text Add to dashboard Cite

Natural bicyclic sesquiterpenes, β‐caryophyllene (BCP) and β‐caryophyllene oxide (BCPO), are present in a large number of plants worldwide. Both BCP and BCPO (BCP(O)) possess significant anticancer activities, affecting growth and proliferation of numerous cancer cells. Nevertheless, their antineoplastic effects have hardly been investigated in vivo. In addition, both compounds potentiate the classical drug efficacy by augmenting their concentrations inside the cells. The mechanisms underlying the anticancer activities of these sesquiterpenes are poorly described. BCP is a phytocannabinoid with strong affinity to cannabinoid receptor type 2 (CB 2), but not cannabinoid receptor type 1 (CB 1). In opposite, BCP oxidation derivative, BCPO, does not exhibit CB 1/2 binding, thus the mechanism of its action is not related to endocannabinoid system (ECS) machinery. It is known that BCPO alters several key pathways for cancer development, such as mitogen‐activated protein kinase (MAPK), PI3K/AKT/mTOR/S6K1 and STAT3 pathways. In addition, treatment with this compound reduces the expression of procancer genes/proteins, while increases the levels of those with proapoptotic properties. The selective activation of CB 2 may be considered a novel strategy in pain treatment, devoid of psychoactive side effects associated with CB 1 stimulation. Thus, BCP as selective CB 2 activator may be taken into account as potential natural analgesic drug. Moreover, due to the fact that chronic pain is often an element of cancer disease, the double activity of BCP, anticancer and analgesic, as well as its beneficial influence on the efficacy of classical chemotherapeutics, is particularly valuable in oncology. This review is focused on anticancer and analgesic activities of BCP and BCPO, the mechanisms of their actions, and potential therapeutic utility.

show abstract

Section: Bcp(o) As Analgesic Agentsmentioning

confidence: 99%

Section: Bcp(o)asanalgesicagentsmentioning

confidence: 99%

β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In this work we used an essential oil – BCP – and a polyunsaturated fatty acid – DHA – to investigate anti‐inflammatory effects. Only one study in the literature combined both substances applied in vitro and in vivo to test the analgesic activity of this combination, revealing potent antinociceptive effects from BCP‐DHA, but they did not present an explanatory hypothesis for this synergistic activity …”

Section: Discussionmentioning

confidence: 99%

“…However, there is little research on the effects of the association of these two substances. It is only known that BCP and DHA together can present potent analgesic action . The objective of this work was therefore to determine the anti‐inflammatory profile of β BCP associated with DHA in a mouse sepsis model induced by intraperitoneal inoculation of Staphylococcus aureus .…”

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory activity of β‐caryophyllene combined with docosahexaenoic acid in a model of sepsis induced by Staphylococcus aureus in mice

et al. 2019

View full text Add to dashboard Cite

BACKGROUND Sepsis is a set of serious organic manifestations caused by an infection, whose progression culminates in exacerbated inflammation and oxidative stress, poor prognosis, and high hospital costs. Antioxidants used against sepsis have been evaluated, including essential oils such as β‐caryophyllene (BCP), and polyunsaturated fatty acids, such as docosahexaenoic acid (DHA). The aim of this study was to evaluate the anti‐inflammatory activity of the association of these two compounds. RESULTS Treatment with BCP‐DHA, at a dose of 200 μL/animal, significantly inhibited the migration of neutrophils in a Cg‐induced peritonitis model. After Staphylococcus aureus infection, in the groups treated with BCP‐DHA there was a significant decrease in the total and differential count of leukocytes, increased expression of cytokines TNF‐α and IFN‐γ in treated groups, an increase of IL‐4 and IL‐5 in B/D and B/D + SA groups, and an augmentation of IL‐6 and IL‐12 groups in B/D + SA groups. Histological and bacterial analysis revealed lower neutrophil migration and lower bacterial load in the infected and treated groups. CONCLUSION In general, the BCP‐DHA association presented anti‐inflammatory activity against two different models of acute inflammation and infection, showing promising potential as a therapeutic adjuvant in sepsis. © 2019 Society of Chemical Industry

show abstract

“…Beta caryophyllene has been found to be a type 2 beta cannabinol receptor agonist and caryophyllene has been approved as a food additive by Food and Drug Administration of United States of America [25] [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of Alligator Pepper on Litter Weight of Rats Fed on High Glycemic Index Diet

Inegbenebor¹,

Eghomwanre²

2017

FNS

View full text Add to dashboard Cite

This study was carried out to find out if alligator pepper can prevent the development of fetal macrosomia in Sprague-Dawley rats fed with high glycemic index diet. Fifteen adult female Sprague-Dawley rats of proven fertility were acclimatized for a period of two weeks in a well-ventilated laboratory and fed with grower's mash and water ad libitum. Thereafter, they were randomly placed in separate cages after which a male Sprague-Dawley rat of proven fertility was introduced into each of the cages containing the female rats. They were left in the cages for three days during, which mating was confirmed to have occurred. The male rats were then withdrawn from the female rats, which were placed in separate maternity cages. The female rats were randomly allocated to three groups A, B and C so there were 5 pregnant rats in each group. The rats in group A were fed with 50 g of grower's mash daily while the rats in groups B and C were fed with 50 g of cooked fermented cassava respectively. All rats were given water ad libitum throughout the duration of the experiment. The rats in groups A and B were intraperitoneally injected with 13.3 ml per Kg body weight of distilled water while the rats in group C were intraperitoneally injected with 13.3 mg/Kg body weight of aqueous extract of alligator pepper respectively. They were observed for 18 -25 days. The litters of the rats in group B had a significantly higher mean weight than the rats in group A while the litters of the rats in group C had a significantly lower mean weight than the rats in groups B. It was concluded that intraperitoneally injected aqueous extract of alligator pepper, in the first trimester of pregnancy, can prevent the development of fetal macrosomia in Sprague-Dawley rats.

show abstract

In Vitro and In Vivo Characterization of the New Analgesic Combination Beta‐Caryophyllene and Docosahexaenoic Acid

Cited by 24 publications

References 31 publications

β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties

β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties

Anti‐inflammatory activity of β‐caryophyllene combined with docosahexaenoic acid in a model of sepsis induced by Staphylococcus aureus in mice

Effect of Alligator Pepper on Litter Weight of Rats Fed on High Glycemic Index Diet

Contact Info

Product

Resources

About