<i>In situ </i>ethylation of organolead, organotin and organomercury species by bromomagnesium tetraethylborate prior to GC‐ICP‐MS analysis

Nsengimana, Hermogène; Cukrowska, Ewa; Dinsmore, Andrew; Tessier, Emmanuel; Amouroux, David

doi:10.1002/jssc.200900204

Cited by 18 publications

(8 citation statements)

References 26 publications

(23 reference statements)

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“…Alternatively, chloroformate [60] and cyanogen bromide [61] have been used as devertization reagents for the determination of seleno amino acids. Moreover, synthesized BrMgEt 4 B was used for in situ ethylation of organolead, organotin and organomercury to replace the commercially available high cost alkylborates [62]. Recently, Yan et al [63] reported to use butyl magnesium bromide as a derivatization reagent to avoid the loss of species specific information of analytes and employed synthesized Pr 3 PbCl as an alternative internal standard to improve the analytical precision and accuracy for the simultaneous determination of different Pb and Hg species.…”

Section: Alkylationmentioning

confidence: 99%

Application of chemical vapor generation in ICP-MS: A review

2013

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Chemical vapor generation (CVG) is an important sample introduction technique, and is widely used for atomic spectrometry for its enhanced sensitivity and selectivity. In the past 30 years, inductively coupled plasma mass spectrometry (ICP-MS) has become a widely used and the most sensitive instrument for (ultra-)trace element determination and elemental speciation. A review of applications of this state-of-the-art coupling of CVG and ICP-MS is presented. Discussion is focused on its applications for both element determination and speciation, including hydride generation, cold vapor generation, photochemical vapor generation, alkylation, and electrochemical vapor generation. In addition, recent studies undertaken isotope dilution calibration in CVG-ICP-MS for achieving improved accuracy and precision are summarized, and the future perspectives are discussed. chemical vapor generation, inductively coupled plasma mass spectrometry, isotope dilution, trace element determination, speciationCitation:

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Section: Alkylationmentioning

confidence: 99%

Application of chemical vapor generation in ICP-MS: A review

2013

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“…Most of the analytical methodologies for determination of TBT are based on gas chromatography (GC) owing to its high resolution and the compatibility with highly sensitive detectors like mass spectrometric (MS), flame photometric (FPD) and microwave induced plasma atomic emission detectors (MIP‐AED) (Birjandi et al ., ; Chou and Lee, ; Tutschku et al ., ; Zachariadis and Rosenberg, ). More recently many workers studied the benefits of hyphenated techniques such as liquid and gas chromatography attached to ICP‐MS (González‐Toledo et al ., ; Nsengimana et al ., ; Point et al ., ; Vahcic et al ., ; Xiao et al ., ) for the speciation analysis of organotins in environmental and biological samples. The accuracy of organotin determination in environmental or biological samples depends not only on the measurement step but also on the sample preparation, sampling and storage conditions, which potentially affect the reliability of the results (Abalos et al ., ).…”

Section: Introductionmentioning

confidence: 98%

Storage stability studies for tributyltin determination in human urine samples using headspace solid‐phase microextraction and gas chromatography mass spectrometry

Zachariadis

Tzollas

Nikolaou

et al. 2012

Biomedical Chromatography

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A headspace solid-phase micro-extraction (HS-SPME) method was employed in order to study the effect of storage conditions of human urine samples spiked with tributyltin (TBT) using gas chromatography and mass spectrometry. To render the analyte more volatile, the derivatization (ethylation) was made in situ by sodium tetraethylborate (NaBEt(4) ), which was added directly to dilute unpreserved urine samples and in buffers of similar acidity. The stability of TBT in human urine matrix was compared with the stability of TBT in buffer solutions of similar pH value. Critical parameters of storage conditions such as temperature and time, which affect the stability of TBT in this kind of matrix, were examined extensively. The tests showed that the stability of TBT remains practically satisfactory for a maximum of 2 days of storage either at +4 or 20°C. Greater variations were observed in the concentration of TBT in human urine samples at +4°C and lower ones at -20°C over a month's storage. The freeze-thaw cycles have negative effect on the stability and should be kept to a minimum. The results from spiked urine samples are also discussed in comparison to those acquired from buffer solutions of equal TBT concentration.

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“…Another advantage of the present technique was detection method. HPLC offers the advantage that the derivatization procedure is not required, which was chosen in this work instead of GC in the reported methods . HPLC has good separation efficiency, fast operation, and many available detectors, such as atomic absorption spectroscopy (AAS) , inductively coupled plasma atomic emission spectroscopy (ICP‐AES) , MS , UV spectrophotometry (UV) , and inductively coupled plasma mass spectrometry (ICP‐MS) .…”

Section: Introductionmentioning

confidence: 99%

Fast and effective low‐temperature freezing extraction technique to determine organotin compounds in edible vegetable oil

Liu

Wan

et al. 2016

J of Separation Science

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Most organotin compounds that have been widely used in food packaging materials and production process show serious toxicity effects to human health. In this study, a simple and low-cost method based on high-performance liquid chromatography with inductively coupled plasma mass spectrometry for the simultaneous determination of four organotins in edible vegetable oil samples was developed. Four organotins including dibutyltin dichloride, tributyltin chloride, diphenyltin dichloride, and triphenyltin chloride were simultaneously extracted with methanol using the low-temperature precipitation process. After being concentrated, the extracts were purified by matrix solid-phase dispersion using graphitized carbon black. The experimental parameters such as extraction solvent and clean-up material were optimized. To evaluate the accuracy of the new method, the recoveries were investigated. In addition, a liquid chromatography with tandem mass spectrometry method was also proposed for comparison. The procedures of extracting and purifying samples for the analysis were simple and easy to perform batch operations, also showed good efficiency with lower relative standard deviation. The limits of detection of the four organotins were 0.28-0.59 μg/L, and the limits of quantification of the four organotins were 0.93-1.8 μg/L, respectively. The proposed method was successfully applied to the simultaneous analysis of the four organotins in edible vegetable oil. Some analytes were detected at the level of 2.5-28.8 μg/kg.

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In situ ethylation of organolead, organotin and organomercury species by bromomagnesium tetraethylborate prior to GC‐ICP‐MS analysis

Cited by 18 publications

References 26 publications

Application of chemical vapor generation in ICP-MS: A review

Application of chemical vapor generation in ICP-MS: A review

Storage stability studies for tributyltin determination in human urine samples using headspace solid‐phase microextraction and gas chromatography mass spectrometry

Fast and effective low‐temperature freezing extraction technique to determine organotin compounds in edible vegetable oil

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