<i>In-silico</i> screening of bioactive phytopeptides for novel anti-ageing therapeutics

Salekeen, Rahagir; Ahmed, Asif; Islam, Emdadul; Billah, Morsaline; Rahman, Hafizur; Islam, Kazi Mohammed Didarul

doi:10.1080/07391102.2020.1859411

Cited by 6 publications

(8 citation statements)

References 45 publications

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“…Other currently available atherotherapeutics and relevant non-citrus peptides have been listed in Table S1. Citrusin I Citrus unshiu Antiinflammatory in-vitro Inhibits PTGS-2 and NF-κB [26] Citrusin II Citrus natsudaidai, Citrus sinensis Anti-aging in-silico Inhibits mTOR; activates SIRT1 and AMPK [27] Citrusin III Citrus natsudaidai, Citrus sinensis functional data reflects a pronounced lack of focused biochemical and molecular biological researchparticularly with no reported studies investigating the peptide or proteinaceous fractions in citrus bioactivity beyond the nutritional protein content.…”

Section: Introductionmentioning

confidence: 99%

Citrus Fruits as Source of Novel Bioactive Peptides: in-vitro and in-silico Analysis of Atheroprotective Potentials

Salekeen,

Akhter,

Islam

et al. 2022

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Citrus Fruits as Source of Novel Bioactive Peptides: in-vitro and in-silico Analysis of Atheroprotective Potentials

Salekeen,

Akhter,

Islam

et al. 2022

Food Funct.

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“…and Dunaliella tertiolecta and relatively low free radical scavenging activities in Alcalase® extracts from Undaria pinnatifida. To the best of our knowledge, the antioxidant properties of EPHs from almost all the algae species included in the study (except Undaria pinnatifida 15 , Ascophyllum nodosum 27 , Nannochloropsis sp. 50 , and Fucus vesiculosus 51 ) have never been evaluated.…”

Section: Resultsmentioning

confidence: 99%

“…Due to these multiple effects on metabolic functions, the identification of suitable sirtuin activating compounds (STACs) is a research field of great interest. Several classes of plant and seaweed polyphenols may increase SIRT1 activity 27 , 28 . Resveratrol (3, 5, 4′-trihydroxystilbene), a polyphenol found in grapes and red wines, is one of the most effective SIRT1 activators 29 .…”

Section: Introductionmentioning

confidence: 99%

Taurine, homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae

Terriente-Palacios

Rubiño

Hortós

et al. 2022

Sci Rep

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Prevention and control of diseases and delaying the signs of ageing are nowadays one of the major goals of biomedicine. Sirtuins, a family of NAD+ dependent deacylase enzymes, could be pivotal targets of novel preventive and therapeutic strategies to achieve such aims. SIRT1 activating and inhibiting compounds, such as polyphenols and bioactive peptides, have been proposed to be involved in the development of many human diseases. The objective of this work was to assess and compare the antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates (EPHs) from a wide number of algae species (24 commercial samples and 12 samples harvested off the Atlantic coast of northern Spain). High antioxidant activities were observed in EPHs from red and green seaweed species. Moreover, 19 samples exhibited SIRT1 activation, while EPHs from the 16 samples were SIRT1 inhibitors. Pearson's correlation test and Principal Component Analysis revealed significant correlations between (1) total peptide and hydrophobic amino acid content in EPHs and their antioxidant activities, and (2) concentrations of taurine, homotaurine, and amino acid gamma aminobutyric acid in EPHs and their SIRT1 modulation activity.

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“…and Dunaliella tertiolecta and relatively low free radical scavenging activities in Alcalase® extracts from Undaria pinnati da. To the best of our knowledge, the antioxidant properties of EPHs from almost all the algae species included in the study (except Undaria pinnati da [15], Ascophyllum nodosum [27], Nannochloropsis sp.…”

Section: Composition Of Algae Protein Hydrolysatesmentioning

confidence: 99%

“…Due to these multiple effects on metabolic functions, the identi cation of suitable sirtuin activating compounds (STACs) is a research eld of great interest. Several classes of plant and seaweed polyphenols may increase SIRT1 activity [27,28]. Resveratrol (3, 5, 4′-trihydroxystilbene), a polyphenol found in grapes and red wines, is one of the most effective SIRT1 activators [29].…”

Section: Introductionmentioning

confidence: 99%

Taurine, Homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae

Terriente-Palacios¹,

Campoy²,

Hortós³

et al. 2022

Preprint

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Prevention and control of diseases and delaying the signs of ageing are nowadays one of the major goals of biomedicine. Sirtuins, a family of NAD+ dependent deacylase enzymes, could be pivotal targets of novel preventive and therapeutic strategies to achieve such aims. SIRT1 activating and inhibiting compounds, such as polyphenols and bioactive peptides, have been proposed to be involved in the development of many human diseases. The objective of this work was to assess and compare the antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates (EPHs) from a wide number of algae species (24 commercial samples and 12 samples harvested off the Atlantic coast of northern Spain). High antioxidant activities were observed in EPHs from red and green seaweed species. Moreover, 19 samples exhibited SIRT1 activation, while EPHs from the 16 samples were SIRT1 inhibitors. Pearson's correlation test and Principal Component Analysis revealed significant correlations between i) total peptide and hydrophobic amino acid content in EPHs and their antioxidant activities, and ii) concentrations of taurine, homotaurine, and amino acid gamma aminobutyric acid (GABA) in EPHs and their SIRT1 modulation activity.

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In-silico screening of bioactive phytopeptides for novel anti-ageing therapeutics

Cited by 6 publications

References 45 publications

Citrus Fruits as Source of Novel Bioactive Peptides: in-vitro and in-silico Analysis of Atheroprotective Potentials

Citrus Fruits as Source of Novel Bioactive Peptides: in-vitro and in-silico Analysis of Atheroprotective Potentials

Taurine, homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae

Taurine, Homotaurine, GABA and hydrophobic amino acids content influences “in vitro” antioxidant and SIRT1 modulation activities of enzymatic protein hydrolysates from algae

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