In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway

Liu, Song; Zhou, Tong; Chen, Dan; Liu, Rong; Qin, Huanhuan; Zhou, Min; Liu, Guang-Qi; Cao, Xiaolu

doi:10.1039/d0fo02388d

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…A recent study reported that puerarin increased synaptic thickness, density, and length, and relieved the calcium overload in the hippocampus and cortical neurons in Aβ 25-35 -induced AD rats. This effect could possibly be attributed to the increased levels of calcium/calmodulin-dependent protein kinase IIα (CaMKIIα) and the activation of the p38 mitogen activated protein kinase-cyclic-adenosine monophosphate (cAMP) response element-binding protein (MAPK-CREB) signaling pathway, which is essential for synaptic plasticity and memory formation [ 26 ]. In addition, puerarin was able to enhance the extension of axons and dendrite lengths, the numbers of neuronal arbors, and synapse formation due to upregulation of a number of proteins involved in neurite or synaptic development, including dynein light chain 2, elongation factor 2, and actin-related protein 2 [ 27 , 28 ].…”

Section: Bioactivity Of Puerarin In Central Nervous System Disordersmentioning

confidence: 99%

Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update

Yu¹,

Du²,

Li³

et al. 2022

Aging and disease

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Due to global population aging and modern lifestyle changes, the incidence of central nervous system (CNS) disorders, such as neurodegenerative diseases, neuropsychiatric disorders, and cerebrovascular diseases, is increasing and has become a major public health challenge. Current medications commonly used in the clinic are far from satisfactory and may cause serious side effects. Therefore, the identification of novel drugs for the effective management of CNS diseases is very urgent. Puerarin, a highly bioactive ingredient isolated from Pueraria lobata , is known to possess a broad spectrum of pharmacological properties including anti-diabetic, anti-inflammatory, anti-antioxidant, neuroprotective, and cardioprotective features. However, its clinical application is limited due to its poor water solubility. Since puerarin has demonstrated a wide range of neuroprotective functions in various CNS diseases, such as Alzheimer’s disease, Parkinson’s disease, cerebral ischemia, depression, and spinal cord injury, it has been attracting increasingly intense attention worldwide. In this review, we intend to extensively summarize the research progress on neuroprotective mechanisms of puerarin in recent years and discuss the future directions of its application in CNS disease treatment.

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Section: Bioactivity Of Puerarin In Central Nervous System Disordersmentioning

confidence: 99%

Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update

Yu¹,

Du²,

Li³

et al. 2022

Aging and disease

View full text Add to dashboard Cite

show abstract

“…It is a major cause of neonatal death and disability ( Kennedy et al, 2022 ). MiR-214 is involved in cell differentiation and apoptosis and is associated with myocardial damage ( Liu S. et al, 2021 ; Xiao et al, 2021 ), hepatocellular carcinoma cell invasion ( Zhao et al, 2022 ), and rectal cancer ( Yang et al, 2021 ). It was shown that PI3K/Akt/mTOR pathway mediates hypoxia-induced apoptosis and autophagy ( Gong et al, 2019 ), and regulation of miR-214 could activate PI3K/Akt/mTOR pathway to alleviate hypoxia-induced apoptosis and autophagy.…”

Section: Puerarin Regulates Pi3k/akt Signal Pathway To Protect the Ne...mentioning

confidence: 99%

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

et al. 2022

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Neurological diseases impose a tremendous and increasing burden on global health, and there is currently no curative agent. Puerarin, a natural isoflavone extracted from the dried root of Pueraria montana var. Lobata (Willd.) Sanjappa and Predeep, is an active ingredient with anti-inflammatory, antioxidant, anti-apoptotic, and autophagy-regulating effects. It has great potential in the treatment of neurological and other diseases. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/Akt) signal pathway is a crucial signal transduction mechanism that regulates biological processes such as cell regeneration, apoptosis, and cognitive memory in the central nervous system, and is closely related to the pathogenesis of nervous system diseases. Accumulating evidence suggests that the excellent neuroprotective effect of puerarin may be related to the regulation of the PI3K/Akt signal pathway. Here, we summarized the main biological functions and neuroprotective effects of puerarin via activating PI3K/Akt signal pathway in neurological diseases. This paper illustrates that puerarin, as a neuroprotective agent, can protect nerve cells and delay the progression of neurological diseases through the PI3K/Akt signal pathway.

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Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases

Chauhan,

Wadhwa,

Mishra

et al. 2024

Mol Neurobiol

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In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway

Abstract: In silico-methods were used to screen out the anti-AD active ingredient via p38MAPK-CREB from the Pueraria lobate, and verified by an in vivo study.

Cited by 5 publications

References 46 publications

Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update

Neuroprotective Mechanisms of Puerarin in Central Nervous System Diseases: Update

Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases

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