Investigating the Potential Therapeutic Mechanisms of Puerarin in Neurological Diseases

Chauhan, Payal; Wadhwa, Karan; Mishra, Richa; Gupta, Saurabh; Ahmad, Fuzail; Kamal, Mehnaz; Iqbal, Danish; Alsaweed, Mohammed; Nuli, Mohana Vamsi; Abomughaid, Mosleh Mohammad; Almutary, Abdulmajeed G.; Mishra, Prabhu Chandra; Jha, Saurabh Kumar; Ojha, Shreesh; Nelson, Vinod Kumar; Dargar, Abha; Singh, Govind; Jha, Niraj Kumar

doi:10.1007/s12035-024-04222-4

Cited by 1 publication

(1 citation statement)

References 152 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…He et al [14] reviewed the protective effects of kudzu root flavonoids and triterpene saponins on the liver through different targeted therapy mechanisms, and summarized the therapeutic potential for different types of liver diseases. Wang et al and Chauhan et al [15,16] summarized the main biological functions and neuroprotective effects of puerarin in some neurological diseases, such as nerve cell damage, Alzheimer's disease, etc. Liu et al and Tomczyk et al [17,18] reviewed the use of kudzu in reducing alcohol consumption.…”

Section: Introductionmentioning

confidence: 99%

Puerariae lobatae Radix: Progress in Extraction, Separation Methods and Pharmacological Activities Research

Gao,

Wang,

Huang

et al. 2024

Separations

View full text Add to dashboard Cite

Kudzu root (Puerariae lobatae Radix) is the tuberous root of Pueraria lobata, family Leguminosae. Kudzu root contains a variety of beneficial active ingredients such as puerarin, daidzin, daidzein, genistenin, 3′-hydroxy puerarin, β-sitosterol, stigmasterol, arachidic acid, and so on. Modern medical research shows that active ingredients in kudzu root are widely used clinically as raw materials for the treatment of hyperglycemia, non-alcoholic fatty liver disease, myocardial infarction, alcohol addiction, oxidative stress, inflammatory response, and retinal blockage due to their various pharmacological effects such as improving cardiovascular circulation, lowering blood lipids, lowering blood pressure, lowering blood sugar, being antipyretic, being estrogen-like, and relieving alcohol. China has rich resources of kudzu root, and active ingredients are usually extracted before it is made into a preparation, so whether the extraction and separation process is reasonable will directly affect the ease of preparation and the efficacy of the treatment. This paper reviews the process methods for the extraction and separation of active ingredients in kudzu root and its common pharmacological activities. The aim is to provide some references for readers to compare the advantages and disadvantages of various extraction and separation methods as well as understand the active ingredients and pharmacological activities of kudzu root.

show abstract