<i>Homalomena pineodora</i>, a Novel Essential Oil Bearing Plant and Its Antimicrobial Activity Against Diabetic Wound Pathogens

Rozman, Nur Amiera Syuhada; Tong, Woei Yenn; Tan, Wen-Nee; Ring, Leong Chean; Yusof, Fahmi Asyadi Bin Md; Sulaiman, Baharuddin

doi:10.1080/0972060x.2018.1526129

Cited by 8 publications

(7 citation statements)

References 31 publications

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“…The antimicrobial activity was evaluated using pathogenic microorganisms previously isolated from patients with chronic diabetic wounds (Rozman et al 2018). The test microorganisms were Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus, MRSA and Streptococcus spp.…”

Section: Antimicrobial Activity 141 Test Microorganismsmentioning

confidence: 99%

Metabolites characterisation of endophytic Phyllosticta fallopiae L67 isolated from Aloe vera with antimicrobial activity on diabetic wound microorganisms

Taher

Tan

Chear

et al. 2022

Natural Product Research

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This study aimed to assess the antimicrobial activity of endophytic Phyllosticta fallopiae L67 isolated from Aloe vera against diabetic wound microorganisms and characterise their active fraction for biologically important metabolites. The dichloromethane (DCM) extract exhibited the most significant activity with inhibition zones ranging from 11.33-38.33 mm. The minimal inhibitory and lethality concentrations of DCM extract ranged from 78.13 to 2500.00 µg/ml and 625.00 to 5000.00 µg/ml, respectively. The extract showed teratogenicity and lethality in the zebrafish model, where peritoneal and hepatic oedema occurred at 62.50 µg/ml, and no abnormality appeared at 31.25 µg/ml. The extract also inhibited more than 82% biofilm formation. Bioassay-guided fractionation on DCM extract yielded 18 fractions and the most active fraction was subjected to UPLC-QTOF-MS/MS analysis. Flavones, stilbenes, flavanonols, isoflavonoids, phenolic glycosides and phenol derivatives were detected. In conclusion, endophytic P. fallopiae possessed bioactive metabolites with significant antimicrobial activity against diabetic wound microorganisms.

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Section: Antimicrobial Activity 141 Test Microorganismsmentioning

confidence: 99%

Metabolites characterisation of endophytic Phyllosticta fallopiae L67 isolated from Aloe vera with antimicrobial activity on diabetic wound microorganisms

Taher

Tan

Chear

et al. 2022

Natural Product Research

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“…On the other hand, essential oil from H. aromatica rhizomes showed high antimicrobial activity against Trichophyton rubrum, T. mentagrophytes, Microsporum fulvum, M. gypseum, Trichosporon beigelii, Candida albicans Epidermophyton floccosum (6,7). Furthermore, the essential oils isolated from H. pineodora also exhibited against 4 Gram positive bacteria (Staphylococcus aureus, Bacillus cereus and B. subtilis), 5 Gram negative bacteria (Proteus mirabilis, Yersinia sp., Shigella boydii, Acinetobacter anitratus and Pseudomonas aeruginosa) and 1 yeast (Candida albicans) (26).…”

Section: Antibacterial Activity Of H Cochinchinensis Acetone Extractmentioning

confidence: 99%

Chemical profile and antibacterial activity of acetone extract of Homalomena cochinchinensis Engl. (Araceae)

Van

Nguyen

et al. 2021

Plant Sci. Today

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Homalomena cochinchinensis Engl. is a rare species which is found in Southern China, Cambodia, Laos and Vietnam and its chemical constituents and bioactivity have not been determined yet. In this study, we identified 32 and 38 compounds in acetone extracts of H. cochinchinensis aerial part and rhizome, respectively via gas chromatography mass spectrometry (GC/MS). The main constituents of acetone extract of the aerial part were 3-((4Z,7Z)-Heptadeca-4,7-dien-1-yl)phenol (18.73%); cis-9,cis-12-Octadecadienoic acid (12.04%); linolenic acid (11.08%); n-Hexadecanoic acid (10.13%); (Z)-3-(Heptadec-10-en-1-yl)phenol (7.09%); ?-Sitosterol (5.58%) and linalool (5.56%). On the other hand, acetone extract of rhizome contained linalool (28.42%); 1,2,3-Propanetriol, 1-acetate (10.13%); 3-((4Z,7Z)-Heptadeca-4,7-dien-1-yl)phenol (5.28%); 3-Buten-2-one, 3-methyl-4-(1,3,3-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl)- (5.28%) and 4-(2,6,6-Trimethyl-cyclohex-1-enyl)-butyric acid (4.54%). Furthermore, this study has also proved the antibacterial activity of acetone extracts from the aerial part and the rhizome of this species for the first time using disk diffusion method. The results showed that the extract of the aerial part could inhibit the growth of 5 out of a total 6 bacterial strains, including Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Staphylococcus aureus; while the susceptible strains to the rhizome extract were 5 strains, such as B. cereus, E. coli, P. aeruginosa, Salmonella typhimurium and S. aureus. The findings suggest the further application of this species in pharmacology and medicine.

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“…The biological properties of EOs are determined by the concentration of their major components; therefore, analyzing the constituents of EOs is necessary to assess the biological activity. The components of EOs of Syzygium aromaticum L. Myrtaceae (clove) [ 16 ], Citrus tangerina (tangerine), Carum carvi (caraway) [ 17 ], and Homalomena pineodora [ 18 ] have been analyzed using gas chromatography/mass spectrometry (GC/MS).…”

Section: Introductionmentioning

confidence: 99%

Mode of Antifungal Action of Daito-Gettou (Alpinia zerumbet var. exelsa) Essential Oil against Aspergillus brasiliensis

Okazaki

Sumitani

Takahashi

et al. 2023

Foods

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Plant-derived essential oils (EOs) are used in medicines, disinfectants, and aromatherapy products. Information on the antifungal activity of EO of Alpinia zerumbet var. exelsa (known as Daito-gettou) found in Kitadaito Island, Okinawa, is limited. Therefore, we aimed to evaluate the antifungal activity of EOs obtained via steam distillation of leaves of Daito-gettou, which is a hybrid of A. zerumbet and A. uraiensis. Daito-gettou EO showed antifungal activity (minimum inhibitory concentration = 0.4%) against Aspergillus brasiliensis NBRC 9455, which was comparable to that of A. zerumbet found in the Okinawa main island. Gas chromatography/mass spectrometry revealed that the main components of Daito-gettou EOs are γ-terpinene, terpinen-4-ol, 1,8-cineole, 3-carene, and p-cymene. Terpinen-4-ol content (MIC = 0.075%) was 17.24%, suggesting that the antifungal activity of Daito-gettou EO was mainly attributable to this component. Daito-gettou EO and terpinen-4-ol inhibited mycelial growth. Moreover, calorimetric observations of fungal growth in the presence of Daito-gettou EO showed a characteristic pattern with no change in the initial growth rate and only a delay in growth. As this pattern is similar to that of amphotericin B, it implies that the action mode of Daito-gettou EO and terpinen-4-ol may be fungicidal. Further studies on the molecular mechanisms of action are needed for validation.

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Homalomena pineodora, a Novel Essential Oil Bearing Plant and Its Antimicrobial Activity Against Diabetic Wound Pathogens

Cited by 8 publications

References 31 publications

Metabolites characterisation of endophytic Phyllosticta fallopiae L67 isolated from Aloe vera with antimicrobial activity on diabetic wound microorganisms

Metabolites characterisation of endophytic Phyllosticta fallopiae L67 isolated from Aloe vera with antimicrobial activity on diabetic wound microorganisms

Chemical profile and antibacterial activity of acetone extract of Homalomena cochinchinensis Engl. (Araceae)

Mode of Antifungal Action of Daito-Gettou (Alpinia zerumbet var. exelsa) Essential Oil against Aspergillus brasiliensis

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