Helicobacter pylori—in vitrosusceptibility to garlic(Allium sativum)extract

Abstract

Gastric cancer is the major cancer in the developing world and one of the top two worldwide. Helicobacter pylori is a bacterium implicated in the etiology of stomach cancer. The incidence of stomach cancer is lower in individuals and populations with high Allium vegetable intakes. Allium vegetables, particularly garlic, have antibiotic activity. Standard antibiotic regimens against H. pylori are frequently ineffective in high-risk populations. As part of our study of the role of Allium vegetable intake on cancer prevention, we wished to investigate its antimicrobial activity against H. pylori. An aqueous extract of garlic cloves was standardized for its thiosulfinate concentration and tested for its antimicrobial activity on H. pylori grown on chocolate agar plates. Minimum inhibitory concentration was 40 micrograms thiosulfinate per milliliter. Staphylococcus aureus tested under the same conditions was not susceptible to garlic extract up to the maximum thiosulfinate concentration tested (160 micrograms/ml). To our knowledge, this is the first report of H. pylori's susceptibility to garlic extract of known thiosulfinate concentration. It is plausible that the sensitivity of H. pylori to garlic extract at such low concentration may be related to the reported lower risk of stomach cancer in those with a high Allium vegetable intake. Furthermore, it may identify a strategy for a low-cost intervention, with few side effects, in populations at high risk for stomach cancer, particularly where antibiotic resistance and the risk of reinfection are high.

Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case‐referent Study of a High‐epidemic Area in Jiangsu Province, China

“…[17][18][19] In vitro, garlic extracts have a potent capacity to eliminate HP. 20) We have no information about HP infection in Yangzhong city, but our data from another high-risk area for stomach cancer (Huaian city of Jiangsu province) indicate that frequent intake of raw garlic and Welsh onion may decrease the OR for HP infection (unpublished results). These studies indicate that a protective role of allium vegetables may not be limited to a particular species, organ, or carcinogen.…”

Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis

“…sativum (Oswega white)) (a gift from Dr Gowsala P Sivam) essentially as described by Sivam et al (1997). Garlic cloves were crushed with a morter and diluted in water 1 : 2.…”

Variação de peso, grau de escolaridade, saneamento básico, etilismo, tabagismo e hábito alimentar pregresso em pacientes com cancêr de estômago

“…Além disso, verificou-se que extrato de alho possui poder bactericida, in vitro, contra o Helicobacter pylori (24) .…”