Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case‐referent Study of a High‐epidemic Area in Jiangsu Province, China

Gao, Chang–Ming; Takezaki, Toshiro; Ding, Jiannan; Li, Maosheng; Tajima, Kazuo

doi:10.1111/j.1349-7006.1999.tb00791.x

Cited by 165 publications

(108 citation statements)

References 24 publications

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“…Irregular lunch-time -has also impact on cancer incidence which is consistent with other studies (Yi et al, 1998;Gao et al, 1999;Cai et al, 2003;Wu et al, 2013). but in Sun`s study there was no significant relationship between irregular lunch-time and risk of gastric cardia cancer (Sun et al, 2013).…”

Section: Discussionsupporting

confidence: 81%

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Modeling of Influential Predictors of Gastric Cancer Incidence Rates in Golestan Province, North Iran

Behnampour¹,

Hajizadeh²,

Zayeri³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Golestan province has a reputation for relatively high incidence rates of gastric cancer in Iran. Along with dietary, lifestyle and environmental influential factors, soil selenium and high levels of pesticide used may exert influence in this region. The present study was designed for modeling the influential predictors on incidence of gastric cancer in Golestan. All registered cases of gastric cancer from March 2009 to March 2010 (49 females and 107 males) were investigated. Data were gathered by both check list and researcher made questionnaire (demographic, clinical and lifestyle characteristics) and analysed using logistic regression. Mean (±SD) age at diagnosis was 62.9±13.8 years. CIR and ASR of gastric cancer showed 9.16 and 13.9 per 100,000 people, respectively. Based on univariate logistic regression, a history of smoking (OR= 2.076), unwashed hands after defecation (OR= 2.612), history of cancer in relatives (OR= 2.473), history of gastric cancer in first-degree relatives (OR= 2.278), numbers of gastric cancers in first-degree relatives (OR= 2.078), history of X-ray and dye exposure (OR= 2.395), history of CT scan encounter (OR= 2.915), improper food habits (OR= 3.320), specific eating behavior (OR= 0.740), consumption of probable high risk foods (OR= 2.942), charred flesh (OR= 1.945), and animal fat (OR= 2.716) were confirmed as a risk factors. Changes in lifestyle may be expected to increase gastric cancer incidence dramatically in the near future. Therefore, appropriate educational interventions should be designed and implemented by competent authorities

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Section: Discussionsupporting

confidence: 81%

“…Along with other studies, results showed that specific eating behaviors (effective food chewing, eating slowly (speed of eating)), were identified as a preventive factor (Gao et al, 1999;Sierpinska et al, 2007;Sun et al, 2013).…”

Section: Discussionmentioning

confidence: 97%

Modeling of Influential Predictors of Gastric Cancer Incidence Rates in Golestan Province, North Iran

Behnampour¹,

Hajizadeh²,

Zayeri³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Our finding is in agreement with reports of several case-control studies. 17,60,64,65 Prospective study on allium vegetables and GC is limited to a cohort study which reported an inverse association between onion and GC. 66 Moreover, this study did not find any evidence to support a protective role for raw vegetables.…”

Section: Discussionmentioning

confidence: 99%

The role of diet and other environmental factors in the causation of gastric cancer in Iran—A population based study

Pourfarzi

Whelan

Kaldor

et al. 2009

Intl Journal of Cancer

126

107

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Despite a declining trend in the incidence of gastric cancer (GC), it is still a major global public health concern of the 21st century. The rates of GC reported from Ardabil Province, Iran, are among the highest in the world. To investigate risk factors for GC in Ardabil, we undertook a population-based case-control study. The study aimed to recruit all Ardabil residents newly diagnosed with GC in the time period of 2004-2005, and 2 controls per case. Participants were interviewed using a structured questionnaire. Ten milliliters of blood was collected for blood grouping and investigating the presence of IgG antibodies against Helicobacter pylori. During the study period, 217 people with GC and 394 controls were recruited. In multivariate analysis, diet and Helicobacter pylori infection (OR 5 2.41; 95% CI: 1.35-4.32) were found to be the factors that were most strongly related to GC. High intake of Allium vegetables (OR 5 0.35) and fruit, especially citrus fruit (OR 5 0.31) and consumption of fresh fish (OR 5 0.37) were significantly protective. On the other hand, consumption of red meat (OR 5 3.40) and dairy products (OR 5 2.28) were positively associated with the risk of GC. People who had a preference for higher salt intake (OR 5 3.10) and drinking strong and hot tea (OR 5 2.64 and 2.85, respectively) were at higher risk. In conclusion, Helicobacter pylori infection as measured by serum IgG as well as the consumption of red meat and dairy products increases the risk of GC in Ardabil, while the intake of fresh fruit and fresh fish decrease the risk. ' 2009 UICC

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“…Epidemiological studies have concluded that dietary intake of Allium vegetables may reduce the risk of various types of malignancies including cancer of the prostate (You et al, 1989;Challier et al, 1998;Gao et al, 1999;Hsing et al, 2002). For example, the risk of prostate cancer was suggested to be significantly lower in men consuming >10 g/day of total Allium vegetables than in men with low total Allium vegetable intake (o2.2 g/day) (Hsing et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Diallyl trisulfide-induced G2–M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C

Xiao

Herman-Antosiewicz²,

Antosiewicz³

et al. 2005

Oncogene

176

195

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Molecular mechanism of cell cycle arrest caused by diallyl trisulfide (DATS), a garlic-derived cancer chemopreventive agent, has been investigated using PC-3 and DU145 human prostate cancer cells as a model. Treatment of PC-3 and DU145 cells, but not a normal prostate epithelial cell line (PrEC), with growth suppressive concentrations of DATS caused enrichment of the G 2 -M fraction. The DATS-induced cell cycle arrest in PC-3 cells was associated with increased Tyr 15 phosphorylation of cyclin-dependent kinase 1 (Cdk1) and inhibition of Cdk1/cyclinB1 kinase activity. The DATStreated PC-3 and DU145 cells also exhibited a decrease in the protein level of Cdc25C and an increase in its Ser 216 phosphorylation. The DATS-mediated decrease in protein level and Ser 216 phosphorylation of Cdc25C as well as G 2 -M phase cell cycle arrest were significantly attenuated in the presence of N-acetylcysteine implicating reactive oxygen species (ROS) in cell cycle arrest caused by DATS. ROS generation was observed in DATS-treated PC-3 and DU145 cells. DATS treatment also caused an increase in the protein level of Cdk inhibitor p21, but DATS-induced G 2 -M phase arrest was not affected by antisense-mediated suppression of p21 protein level. In conclusion, the results of the present study indicate that DATS-induced G 2 -M phase cell cycle arrest in human prostate cancer cells is caused by ROS-mediated destruction and hyperphosphorylation of Cdc25C.

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Protective Effect of Allium Vegetables against Both Esophageal and Stomach Cancer: A Simultaneous Case‐referent Study of a High‐epidemic Area in Jiangsu Province, China

Cited by 165 publications

References 24 publications

Modeling of Influential Predictors of Gastric Cancer Incidence Rates in Golestan Province, North Iran

Modeling of Influential Predictors of Gastric Cancer Incidence Rates in Golestan Province, North Iran

The role of diet and other environmental factors in the causation of gastric cancer in Iran—A population based study

Diallyl trisulfide-induced G2–M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C

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