Helicobacter pyloriinfection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis

Abstract

BackgroundOver the last few years, epidemiological studies have shown that infection with Helicobacter pylori has a major effect on micronutrient deficiency as well as on adverse pregnancy outcomes. Importantly, there are gaps in understanding the linkage of H. pylori infection with micronutrients deficiency in pregnant women.ObjectiveWe conducted a systematic review and meta-analysis to estimate the association between H. pylori infection and micronutrient deficiencies in pregnant women.MethodsA systematic literature search was conducted for relevant articles using PubMed, Web of Science, and Scopus database from inception to March 2020. The OR with 95% CIs was determined by meta-analysis of data extracted from the selected studies.ResultsFrom 2384 primary articles, 6 studies were selected for systematic reviews and 4 studies distinctively (with 1274 participants: 553 cases and 721 controls) were selected for meta-analysis. The meta-analysed fixed effect model estimated the odds of having H. pylori infection was not significantly higher among pregnant women with micronutrient deficiencies than those without deficiencies (OR=1.12, 95% CI 0.88 to 1.42, p=0.37). In the subgroup analysis, no correlation was found between H. pylori infection and vitamin B12 (OR=0.74, 95% CI 0.45 to 1.21, p=0.22), folate (OR=1.07, 95% CI 0.73 to 1.58, p=0.73), and ferritin (OR=0.81, 95% CI 0.51 to 1.31, p=0.4). However, a positive correlation was found between iron-deficiency anaemia (IDA) and H. pylori infection (OR=16.23, 95% CI 4.19 to 62.93, p<0.0001) during pregnancy.ConclusionH. pylori infection is associated with increased risk of IDA but not with deficiency of other micronutrients in pregnancy.PROSPERO registration numberCRD42019135683.

Treatment regimens used in the management of Helicobacter pylori in Colombia

“… 7 , 17 The prevalence in women in most studies is probably due to iron deficiency, which is more common in women 18 and associated with an increased risk of H. pylori infection. 19 …”

Effect of Helicobacter pylori Infection on Macromineral and Trace Element Status—Systematic Review and Meta‐Analysis

“…Additionally, the same result was obtained when comparing Hp ‐positive and control children concerning serum zinc status. In similar studies conducted in adults (24) and in pregnant women (25), the low number of primary studies addressing this question prevented a quantitative analysis of these outcomes.…”

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

“…This finding suggests a significant relationship between H. pylori and increased homocysteine levels. However, in another analysis conducted on pregnant women, it was observed that neither vitamin B12 (OR = 0.74, 95% CI: 0.45–1.21) nor folate (OR = 1.07, 95% CI: 0.73–1.58) could account for changes in homocysteine levels 89 . These results indicate that the influence of H. pylori infection on homocysteine levels may vary depending on the population studied or other factors that were not accounted for in this analysis.…”