<i>Helicobacter pylori</i>infection and esophageal cancer risk: An updated meta-analysis

Xie, Fa Jun; Zhang, Yi Ping; Zheng, Qiu; Jin, Hongchuan; Wang, Fa Liang; Chen, Ming; Shao, Lan; Zou, De Hong; Yu, Xin; Mao, Wei

doi:10.3748/wjg.v19.i36.6098

Cited by 137 publications

(112 citation statements)

References 40 publications

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“…At the same time, adenocarcinoma rates have been increasing in Western countries, including the United States, Australia, France, and England, likely due to increasing obesity, which increases the risk for GERD, Barrett esophagus, and subsequent development of esophageal adenocarcinoma (88). Increasing adenocarcinoma rates might also be related to the declining prevalence of H. pylori infection, which may protect against this type of esophageal cancer (89)(90)(91).…”

Section: Esophagusmentioning

confidence: 99%

Global Cancer Incidence and Mortality Rates and Trends—An Update

Torre

Siegel

Ward

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

3,112

2,186

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There are limited published data on recent cancer incidence and mortality trends worldwide. We used the International Agency for Research on Cancer's CANCERMondial clearinghouse to present age-standardized cancer incidence and death rates for [2003][2004][2005][2006][2007]. We also present trends in incidence through 2007 and mortality through 2012 for select countries from five continents. High-income countries (HIC) continue to have the highest incidence rates for all sites, as well as for lung, colorectal, breast, and prostate cancer, although some low-and middle-income countries (LMIC) now count among those with the highest rates. Mortality rates from these cancers are declining in many HICs while they are increasing in LMICs. LMICs have the highest rates of stomach, liver, esophageal, and cervical cancer. Although rates remain high in HICs, they are plateauing or decreasing for the most common cancers due to decreases in known risk factors, screening and early detection, and improved treatment (mortality only). In contrast, rates in several LMICs are increasing for these cancers due to increases in smoking, excess body weight, and physical inactivity. LMICs also have a disproportionate burden of infection-related cancers. Applied cancer control measures are needed to reduce rates in HICs and arrest the growing burden in LMICs.Cancer Epidemiol Biomarkers Prev; 25(1); 16-27. Ó2015 AACR.

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Section: Esophagusmentioning

confidence: 99%

Global Cancer Incidence and Mortality Rates and Trends—An Update

Torre

Siegel

Ward

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

3,112

2,186

View full text Add to dashboard Cite

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“…Недавний метаанализ F. Xie и соавт. [70] под-твердил обратную корреляцию между инфекцией H. pylori и АКП у жителей восточных и западных стран. Тем не менее остается неясным, может ли эрадикация микроорганизма приводить к прогрессированию клинической и эндоскопической картины ГЭРБ, так как результаты исследований в этом направлении про-тиворечивы [71,72].…”

Section: терапевтический архив 8 2015unclassified

Helicobacter pylori infection and extragastroduodenal diseases

Маев¹,

Andreev²,

Kucheryavyi³

2015

Ter. arkh.

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АннотацияНа настоящее время достоверно определена клиническая значимость инфекции Helicobacter pylori в рамках развития целого ряда заболеваний гастродуоденальной зоны, включая хронический гастрит, язвенную болезнь желудка и двенад-цатиперстной кишки, MALT-лимфому, а также аденокарциному желудка. В консенсусе Маастрихт IV (2010 г.), определя-ющем международные стандарты диагностики и лечения инфекции H. pylori, экспертный совет постановил, что имеются доказательства возможной ассоциации инфекции H. pylori с развитием ряда экстрагастродуоденальных заболеваний (ЭГДЗ), представленных железодефицитной анемией неуточненной этиологии, идиопатической тромбоцитопенической пурпурой и дефицита витамина В 12 . При этих заболеваниях рекомендовано проведение диагностики инфекции H. pylori и при положительных результатах тестирования -эрадикация микроорганизма. За последнее время проведено большое количество исследований, посвященных изучению связи инфекции H. pylori и с другими ЭГДЗ. В настоящей статье приво-дится обзор теоретических и эпидемиологических данных ассоциации H. pylori с заболеваниями органов сердечно-сосу-дистой системы (атеросклероз, инфаркт миокарда), центральной нервной системы (болезнь Альцгеймера, болезнь Пар-кинсона), поджелудочной железы (аутоиммунный панкреатит, рак поджелудочной железы), онкологическими (аденомы толстой кишки, колоректальный рак, гепатоцеллюлярная карцинома), дерматологическими (хроническая спонтанная кра-пивница, псориаз) а также другими ЭГДЗ. В обзоре освещается потенциальная защитная роль H. pylori при заболеваниях с атопическим элементом генеза и осложненном течении гастроэзофагеальной рефлюксной болезни (пищевод Барретта, аденокарцинома пищевода). At present, the clinical significance of Helicobacter pylori infection has been validly determined within the development of a diversity of gastroduodenal diseases, including chronic gastritis, gastroduodenal ulcer, MALT lymphoma, and gastric adenocarcinoma. The Expert Council's Maastricht IV consensus (2010) determining international standards for the diagnosis and treatment of H. pylori infection is that there is evidence that the latter may be associated with the development of a number of extragastroduodenal diseases (EGDDs) presented by iron-deficiency anemia of unspecified etiology, idiopathic thrombocytopenic purpura, and vitamin B 12 deficiency. In these diseases, it is recommended that infection with H. pylori be diagnosed and, if the test is positive, this microorganism be eradicated. A large number of investigations have been recently conducted to examine the association of H. pylori infection with other EGDDs. This paper reviews theoretical and epidemiological data on the association of H. pylori with diseases of the cardiovascular (atherosclerosis, myocardial infarction) and central nervous (Alzheimer's disease, Parkinson's disease) systems, pancreas (autoimmune pancreatitis, pancreatic cancer), oncological (colonic adenomas, colorectal cancer, hepatocellular carcinoma), dermatological (chronic spontaneous urticaria), and ot...

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“…However, H pylori infection has been associated with a lower risk of esophageal cancer, probably due to reduced acid reflux and epithelial damage in those tissues. 67,68 Esophageal cancer is a serious malignancy with regard to mortality (sixth among all cancers worldwide) and prognosis. Its incidence is expected to increase during the next 10 years.…”

Section: Aerodigestive Cancersmentioning

confidence: 99%

Mechanistic and Technical Challenges in Studying the Human Microbiome and Cancer Epidemiology

Verma

2016

Technol Cancer Res Treat

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This article reviews the significance of the microbiome in cancer epidemiology, mechanistic and technical challenges in the field, and characterization of the microbiome in different tumor types to identify biomarkers of risk, progression, and prognosis. Publications on the microbiome and cancer epidemiology were reviewed to analyze sample collection and processing, microbiome taxa characterization by 16S ribosomal RNA sequencing, and microbiome metabolite characterization (metabotyping) by nuclear magnetic resonance and mass spectrometry. The analysis identified methodology types, research design, sample types, and issues in integrating data from different platforms. Aerodigestive cancer epidemiology studies conducted by different groups demonstrated the significance of microbiome information in developing approaches to improve health. Challenges exist in sample preparation and processing (eg, standardization of methods for collection and analysis). These challenges relate to technology, data integration from ''omics'' studies, inherent bias in primer selection during 16S ribosomal RNA sequencing, the need for large consortia with well-characterized biospecimens, cause and effect issues, resilience of microbiota to exposure events (requires longitudinal studies), and expanding studies for fungal and viral diversity (most studies used bacterial 16S ribosomal RNA sequencing for microbiota characterization). Despite these challenges, microbiome and cancer epidemiology studies are significant and may facilitate cancer risk assessment, diagnosis, and prognosis. In the future, clinical trials likely will use microbiota modifications to improve the efficacy of existing treatments.

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Helicobacter pyloriinfection and esophageal cancer risk: An updated meta-analysis

Abstract: H. pylori infection is associated with a decreased risk of ESCC in Eastern populations and a decreased risk of EAC in the overall population.

Cited by 137 publications

References 40 publications

Global Cancer Incidence and Mortality Rates and Trends—An Update

Global Cancer Incidence and Mortality Rates and Trends—An Update

Helicobacter pylori infection and extragastroduodenal diseases

Mechanistic and Technical Challenges in Studying the Human Microbiome and Cancer Epidemiology

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