Helicobacter pylori and Non‐malignant Diseases

Abstract

This paper reviews new literature data from March 2004 to April 2005 about the association between Helicobacter pylori and non-malignant disease of the upper gastrointestinal tract. Eradication of H. pylori is indicated for all patients with non-malignant diseases associated with this pathogen. However, its effect is variable, ranging from the highest benefit in the cure of peptic ulcer disease to a small benefit in patients with non-ulcer dyspepsia. Test and treat strategy is still cost-effective for management of patients with uninvestigated dyspepsia. The only limitations of the strategy are the patient's age and the cost benefit ratio in case of low prevalence of the infection. H. pylori eradication is of value in chronic NSAID users, but is insufficient to prevent NSAID-related ulcer disease. In developed countries H. pylori eradication does not cause gastro-esophageal reflux disease (GORD), however, a negative association between H. pylori and GORD does exist, especially in Asia, but the nature of this relationship should be further clarified.

Prevalence of Helicobacter pylori in Turkish children with celiac disease and its effect on clinical, histopathological, and laboratory parameters

“…There are numerous studies on the possible role of this bacterium in the etiology in both gastrointestinal and extra-gastrointestinal situations. These studies have concluded that while HP infection can cause some diseases, it can also protect against others [22]. For example, it was reported that HP infection decreases the risk of allergic reactions, atopic diseases, autoimmune thyroid disease, autoimmune gastritis and other inflammatory situations [23–25].…”

“…Similarly, Siamondi et al [32] also detected a slight correlation between duodenal histological findings and HP prevalence. Kupcinskas and Malfeltheiner [22] reported that the presence of HP infection was observed more frequently in CD patients with a slight change in their histopathology. There are also some studies that claim the opposite argument; for example, Rostami-Nejad et al [30] reported that there is no relationship between histopathological damage and HP infection in CD cases.…”

Celiac disease and Hp infection association in Iran

“…Hp has been positively identified as the main cause of active chronic gastritis and its major complications (peptic ulcer disease, gastric adenocarcinoma, and primary gastric MALT lymphoma), with numerous studies carried out to explore the possible etiological role of this bacterium in a variety of both gastrointestinal and extra-intestinal conditions (28,29). Investigations on the relationship between Hp infection and CD have yielded conflicting results (11,12), probably because of the different prevalence of Hp in the populations studied.…”

Randomized comparison of two rescue therapies for Helicobacter pylori infection

“…Helicobacter pylori ( H. pylori ) infection plays an important role in the development of chronic gastritis, gastric ulcer, duodenal ulcer, gastric adenocarcinoma and gastric mucosa‐associated lymphoid tissue lymphoma (MALToma) [1–4]. Cure of H. pylori infection prevents ulcer recurrence [3,4], and may lead to a significant reduction of gastric cancer risk among those without any gastric atrophy, intestinal metaplasia and dysplasia [5].…”