Prevalence of Helicobacter pylori in Turkish children with celiac disease and its effect on clinical, histopathological, and laboratory parameters

Abstract

IntroductionThe aim of the study was to assess the prevalence of Helicobacter pylori (HP) in children with celiac disease (CD) and its relationship with clinical, histopathological, and laboratory parameters.Material and methodsTwo hundred and fifty-six patients with serologically and histopathologically diagnosed CD at the Pediatric Gastroenterology Department, Turkey, from January 2012 to March 2017, were included in the study, as well as 1012 patients with dyspeptic complaints. Biopsies of the duodenum and antrum were taken; the existence of HP and the histological level of damage were studied. HP (+) and HP (–) cases were compared according to age, sex, noted complaints, and clinical and laboratory features.ResultsSeventy (27.4%) CD patients and 270 (26.7%) patients with dyspeptic complaints were HP (+). The diagnostic age was higher in HP (+) cases, and diarrhea and abdominal distension were significantly higher. Although hemoglobin, ferritin, vitamin B12, and transferrin saturation were lower in HP (+) cases, the differences were not statistically significant. The serum folate level in the HP (+) group was significantly lower compared to the HP (–) group.ConclusionsThe prevalence of HP was not increased in cases of CD. The CD was diagnosed later in HP (+) cases, distension and diarrhea complaints were more frequent, and folate deficiency was significant.

Intracellular Presence of Helicobacter pylori and Its Virulence-Associated Genotypes within the Vaginal Yeast of Term Pregnant Women

“…Due to its high prevalence and associated pathologies, H. pylori is the subject of detailed studies. Nevertheless, the manner in which it disseminates is not yet fully understood [ 36 , 37 , 38 , 39 , 40 ]. So far, H. pylori genes have been amplified from different samples of human origin, such as oral plaque, feces, nasal secretions, lacrimal fluid and saliva, the oral cavity being considered one of the main sources of infection [ 41 , 42 ].…”

Review: Helicobacter pylori infection in children

“…A number of studies identified correlations of H pylori infection in children with a variety of gastrointestinal diseases including autoimmune gastritis, 14 celiac disease, 15,16 and parasitic infection 17 . However, association does not prove causation and confounding factors likely account for these associations.…”

Review article: exposure to microbes and risk of coeliac disease

“…A weak protective role of H. pylori in CD was reported in some but not all previous studies. However, since study participants are mostly enrolled from endoscopy clinics, there is always a risk of selection bias due to a high prevalence of H. pylori in those referred for upper endoscopy 71‐80 . Studies using randomly selected controls and non‐invasive methods to identify H. pylori have uniformly reported no significant associations 81‐86 .…”