Helicobacter pyloriand Gastritis in Children with Abdominal Complaints

Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis

“…[16][17][18] Both gastric atrophy and intestinal metaplasia are considered to be premalignant stomach cancer lesions. 2,19,20 In contradiction to previous studies that did not use the updated Sydney system, and which reported that gastric atrophy and intestinal metaplasia were rare in children, 21,22 our study showed a significantly higher prevalence of gastric atrophy in H. pylori-infected children. In addition, we also noted intestinal metaplasia in 13.5% of H. pylori-infected children, though the difference from the uninfected group was not statistically significant.…”

“…24 The higher prevalence of glandular atrophy in our study may have resulted from a more cautious evaluation of low-grade glandular atrophy with the updated Sydney system, because grade 1 atrophy may have been regarded as negative in most of the studies of children in which the updated Sydney system was not used. 21,22 The higher prevalence of glandular atrophy in our study, even though most was low grade, suggests that the process of gastric atrophy begins in the early phase of H. pylori infection. Intestinal metaplasia is also known to be rare in children; nevertheless, we found that low-grade intestinal metaplasia occurred in 13.5% of infected children, but that intestinal metaplasia was absent in all H. pylori-uninfected children.…”

Helicobacter pylori (H. pylori) in Gastric Mucosa of Children with Abdominal Complaints: Immunohistochemistry Detects Antigen‐Reactive Corpus Mucosa Cells

“…The prevalence of Helicobacter pylori ( H. pylori ) infection in Estonian children is high. Over 50% of children are affected based on either histological [ 1] or serological [ 2] methods.…”

Validierung eines kindgerechten 13 C-Harnstoff-Atemtests zur Helicobacter-pylori-Diagnostik

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Eine Infektion mit Helicobacter pylori gilt mittlerweile auch im Kindesalter als eine der Hauptursachen fü r das Entstehen von chronisch rezidivierenden Bauchschmerzen auf dem Boden einer Typ-B-Gastritis [2,7,12,13,18,21,23].Zunä chst war nur eine invasive gastroskopische Diagnosestellung mö glich. Dabei wurde eine Biopsie entnommen und diese histologisch begutachtet oder mit einem Ureaseschnelltest untersucht.

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“…Eine Infektion mit Helicobacter pylori gilt mittlerweile auch im Kindesalter als eine der Hauptursachen fü r das Entstehen von chronisch rezidivierenden Bauchschmerzen auf dem Boden einer Typ-B-Gastritis [2,7,12,13,18,21,23].…”