Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis

Kim, Kyung-Mo; Oh, Young Lyun; Ko, Jae Sung; Choe, Yon Ho

doi:10.1007/s00535-003-1282-9

Cited by 26 publications

(22 citation statements)

References 30 publications

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“…However, other studies have reported a significant incidence of gastric atrophy (42%-55%) and intestinal metaplasia (13%-21%) in children (11,14) . Interestingly, a higher incidence of atrophic gastritis has been observed in children from countries with high incidence of gastric cancer (20) .…”

Section: Discussionmentioning

confidence: 89%

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Langner

Machado

Patricio

et al. 2009

Arq. Gastroenterol.

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-Context -Although Helicobacter pylori infection is prevalent in our country, there are few studies evaluating the associated histological abnormalities in children. Objective -To evaluate the histological features of the gastric mucosa in children and adolescents with Helicobacter pylori gastritis. Methods -One hundred and thirty two gastric biopsies from 22 symptomatic patients infected with H. pylori (14F/8M, median age 10 y 5 mo, age range 2 y 11 mo to 16 y 9 mo) were evaluated. Evaluated gastric regions included: antrum (lesser and greater curvature), corpus (lesser and greater curvature), incisura angularis and fundus. Histological examination was performed according to the Updated Sydney System, and regional scores for polymorphonuclear and mononuclear cell infiltrate as well as bacterial density were generated. Results -Fifteen (68.2%) patients presented H. pylori-chronic active gastritis, six (27.3%) presented antrum-predominant H. pylori-chronic active gastritis, and one (4.5%) presented corpus-predominant H. pylori-chronic active gastritis. Polymorphonuclear cell infiltrate and mononuclear cell infiltrate were observed in 93.9% and 98.5% of the biopsy specimens, respectively. Higher histological scores for polymorphonuclear infiltrate, mononuclear infiltrate, and bacterial density were observed in the gastric antrum. Intestinal metaplasia and gastric atrophy were not identified in any patient. Lymphoid aggregates and lymphoid follicles were observed in the gastric antrum of three (13.6%) and seven (31.8%) patients, respectively, but they were not related to antral nodularity. Conclusions -Chronic active gastritis was observed in all patients with H. pylori infection. However, antral or corporeal predominance was not observed in most patients.

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Section: Discussionmentioning

confidence: 89%

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Langner

Machado

Patricio

et al. 2009

Arq. Gastroenterol.

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“…However, one study reported relatively high prevalence of gastric atrophy and low-grade intestinal metaplasia in H. pylori -infected children compared to uninfected children [ 18 ].…”

Section: Histopathologic Findings In H Pylori -Infected Childrenmentioning

confidence: 99%

Specific Conditions: Children

Yang

2016

Helicobacter Pylori

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Helicobacter pylori ( H. pylori ) infection is usually acquired during childhood, causing various diseases even in children. When applying diagnostic tests to children suspected of H. pylori infection, there are some differences between children and adults, although endoscopy with biopsies is also recommended for the initial diagnosis of H. pylori infection in children. On endoscopy, nodular gastritis is a pathognomonic gross fi nding of childhood H. pylori infection. On histopathology of gastric tissues, infi ltration of lymphocytes and plasma cells and formation of mucosa-associated lymphoid tissue are the prominent features in children. Noninvasive diagnostic methods are also available and well validated in children. Both the 13 C-urea breath test (UBT) and the H. pylori stool antigen test based on the enzyme immunoassay using monoclonal antibody are reliable in identifying H. pylori status before and after therapy. However, when applying UBT to children younger than 6 years, test results should be interpreted cautiously because they tend to have high false positives. Serologic tests or urine tests are not recommended in children because of low diagnostic accuracy.

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“…Half of the global population is infected by HP [6]. Chronic inflammation with H. pylori infection leads to mucosal atrophy and intestinal metaplasia, conditions that are believed to be precursors of gastric cancer [6,12]. The development of gastric cancer has been shown to be a multi step process, ranging from chronic gastritis to atrophy, intestinal metaplasia, dysplasia and finally gastric cancer [9].…”

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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P53 protein and Ki-67 expression in chronic gastritis patients with positive Helicobacter pylori infection

Hegazi

Hassan

El-Atrebi

et al. 2011

Journal of Genetic Engineering and Biotechnology

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The present study was carried out to assess the predictive value and expression of the proliferative activity of Ki-67 and the expression of p53 protein in Helicobacter pylori associated chronic gastritis. This study comprised archival blocks from 20 dyspeptic patients who at National Hepatology and Tropical Medicine Research Institute underwent a diagnostic oesophago-gastroduodenoscopy with multiple gastric antral endoscopic biopsies for histological examination. The blocks were cut at 5 nM thicknesses, stained by hematoxylin and eosin to score the inflammatory grade and subjected to Giemsa stain to assess H. pylori infection, and then immune-histochemical method was done to determine protein P53 and Ki-67. The obtained results indicated that there was no significant association between the expression of Ki67 and P53 in the studied cases. There was no significant association between Ki67 and P53 in the presence of intestinal atrophy, intestinal metaplasia, intestinal activity and intestinal inflammation. While, there was significant association between Ki67 and P53 in intestinal dysplasia, P = 0.015, 0.025, respectively. It could be concluded that the significant association of the proliferative marker Ki-67 and apoptotic marker p53 protein with intestinal dysplasia may be one of the main predictive values in the development of gastric carcinoma in patients with gastritis secondary to H. pylori infection.

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Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis

Cited by 26 publications

References 30 publications

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Specific Conditions: Children

P53 protein and Ki-67 expression in chronic gastritis patients with positive Helicobacter pylori infection

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