P53 protein and Ki-67 expression in chronic gastritis patients with positive Helicobacter pylori infection

Hegazi, A. A.; Hassan, Elham A.; El-Atrebi, Kamal A; El-Bassyouni, Hala T.

doi:10.1016/j.jgeb.2011.05.008

Cited by 5 publications

(4 citation statements)

References 9 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the age range from 14-84 years with mean 46 years ± 17.2, male to female ratio was 7:8, in Morales-Fuentes et al (28) study the range of age was 55-81 years and male to female ratio 5:6, while in Azza et al (25) study the patients mean age was 53 years ± 5.1 and male to female ratio 1.75:1, and in Zainab et al (29) study the patients' age range was 11 -82 years (mean of 46.5 years) with a male to female ratio of 1.38:1. Ki67 & P53 expressions in this study were signi cantly detected more in age group (42-55) years, also the expression of both Ki67 & P53 were seen in females more than males .This discrepancy of results among different studies might be due to bias in data collection of some researches.…”

Section: Discussionmentioning

confidence: 45%

“…Many researchers have studied the expression of Ki67 & P53 in both positive and negative HP gastritis, gastric ulcer, and cancer. In this study, the expression of Ki67 & P53 were assessed only in positive HP gastritis and the expression of Ki67 & P53 were detected in 83.3% of cases, a higher percentage more than many other studies, such as: Azza et al (25) study in which Ki67 & P53 expression were 54.5%, 72.7% respectively, Cesar et al (26) study in which P53 expression was 45%, Afaf et al (27) study in which P53 expression was 32.7%, while in Morales-Fuentes et al (28) study, the P53 expression was 91% which is more than this study. The differences could be due to the different sample size of the cases taken by the studies, different genetic background, variation in food types between the nations, etc.…”

Section: Discussionmentioning

confidence: 65%

See 1 more Smart Citation

An Immuno-Histochemical Assessment of Ki67, P53 Over-Expression in Helicobacter Pylori Positive Gastritis.

Tawfeeq

Hamdi

Al-azzo

2021

Preprint

View full text Add to dashboard Cite

Background and Objective: Helicobacter pylori infection of the stomach is a common disease and the resulting changes from it are numerous and deserve to be in the focus of researchers' attention. The aim of this study is to assess the expression of mutant P53 protein and Ki-67 markers in patients with gastritis secondary to Helicobacter pylori.Methods: Thirty samples with positive Helicobacter pylori gastritis were included in a retrospective study in Mosul / Iraq. The histological parameters were assessed using the Sydney system, then the expression of Ki67 and P53 expression were studied by immunohistochemical methods. The significance level was appointed at (0.05).Results: Ki67 and P53 expression were found in 83.3% of the total cases. The study results show that 92% of positive Ki67, P53 cases had chronic inflammatory cell infiltration, polymorph nuclear cells infiltration, and atrophy. Whereas 96% of positive Ki67 cases had no metaplasia, 92% of the positive P53 cases had no metaplasia. The results also showed that only 16% of the positive Ki67 cases had dysplastic changes, and 24 % of the positive cases of P53 cases were showed dysplasia. moreover, whenever P53 was negative; there is neither metaplasia nor dysplasia in the tissue, this does not apply to Ki67 negative cases.Conclusions: Ki67, P53 expressions increase with chronicity of Helicobacter pylori-positive gastritis, P53 expression is amplified when atrophy is present in these samples

show abstract

Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 65%

An Immuno-Histochemical Assessment of Ki67, P53 Over-Expression in Helicobacter Pylori Positive Gastritis.

Tawfeeq

Hamdi

Al-azzo

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…It is conceivable that tumours with a worse outcome may have a higher proliferation index with Ki-67 and a higher probability of mutation in tumour suppressor genes, such as P53 (24). This may be one of the main mechanisms in the development of carcinoma (37).…”

Section: Discussionmentioning

confidence: 99%

Correlation between Expression of Ki67 with Her-2 and p53 Tumour Markers in Breast Cancer Patients

Sheikhpour¹,

Poorhosseini²

2015

West Indian Med J

View full text Add to dashboard Cite

Introduction: Breast cancer is the most common cancer in women. The importance of several molecular markers in breast cancer has generated interest in recent years. The assessment of biomarkers such as Ki67, Her-2 and P53 can be valuable in predicting the outcomes of diseases and decision-making for their optimal treatment. The purpose of this study is to investigate the relationships among Ki67, Her-2 and P53 tumour markers in breast cancer patients. Subjects and methods: In this study, 184 breast cancer patients were chosen. Immunohistochemistry technique was used for detecting the expressions of Ki67, Her-2 and P53 proteins in breast cancer patients. For the correlations among the parameters, Fisher exact test and Spearman's rho were used. In all the tests, the p-value was considered significant if it were less than 0.05. Results: In this study, Ki67 positive, P53 and Her-2 positive, were found, respectively in 53.2%, 38.5% and 54.6 % of the patients. There was a significant relationship between Ki67 and P53 (p < 0.05). But, there were no relationships among Ki67 and Her-2 and the clinicopathological parameters (p > 0.05). Conclusion: Breast cancer progression is often associated with the alterations in the expressions of Ki67, P53 and Her-2 tumour markers. These changes may affect the treatment decisions. Also, the significant relationship between Ki67 and P53 protein showed that cell proliferation may be related to the over-expression of P53 protein in breast cancer patients.

show abstract

“…The International Agency for Research on Cancer (IARC) classified H. pylori bacterium as a Group I carcinogen [ 25 ] H. pylori is a pathogen that colonises the gastric epithelium and causes chronic inflammation and considerably increases the risk of developing GC [ 26 ] . Our study showed that H. pylori were significantly associated with intestinal-type and diffuse GCs compared to GISTs and chronic gastritis, this comes by previous reports [ 27 ] [ 28 ] [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Overview of MDM2 and B-RAF Expression in Gastric Lesions

Aboushousha¹,

Helal²,

Hammam³

et al. 2018

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND:Globally, gastric cancer (GC) it is the fourth most common cancer and the third cause of cancer-related deaths. Overexpression of MDM2 and B-RAF appeared to be increased in malignancy and associated with poor prognosis in several human tumours, but their role in gastric cancer remains controversial.AIM:We had investigated the immunohistochemical expression of MDM2 and B-RAF in 136 gastric lesions with/without H. pylori association.MATERIAL AND METHODS:Studied specimens include chronic gastritis (32), intestinal type GC (70), diffuse GC (22) and gastrointestinal stromal tumours (GIST) (12).RESULTS:MDM2 expression increased significantly in intestinal GC compared to other groups (p < 0.001), while B-RAF expression increased significantly in GIST compared to other groups (p < 0.001). H. pylori increased expression of MDM2 in intestinal GC cases but did not affect B-RAF expression. MDM2 expression correlated with high grade of tumor differentiation (p < 0.001), deep invasion (p < 0.05), nodal metastases (p < 0.05) and distant metastases (p < 0.1) in intestinal GC, while B-RAF expression did not correlate with TNM stage (p < 0.1).CONCLUSION:MDM2 up-regulation was more frequent in intestinal GC, while B-RAF up-regulation was more frequent in GIST compared to other groups; MDM2 expression in intestinal GC was correlated with H. pylori association, high grade of differentiation, deep invasion, nodal and distant metastases, meanwhile, B-RAF expression was correlated with high-grade intestinal GC but did not correlate with H. pylori or TNM stage. The possible role of both MDM2 and B-RAF in predicting progression of gastric tumours and prognosis deserves further investigations.

show abstract

P53 protein and Ki-67 expression in chronic gastritis patients with positive Helicobacter pylori infection

Cited by 5 publications

References 9 publications

An Immuno-Histochemical Assessment of Ki67, P53 Over-Expression in Helicobacter Pylori Positive Gastritis.

An Immuno-Histochemical Assessment of Ki67, P53 Over-Expression in Helicobacter Pylori Positive Gastritis.

Correlation between Expression of Ki67 with Her-2 and p53 Tumour Markers in Breast Cancer Patients

Overview of MDM2 and B-RAF Expression in Gastric Lesions

Contact Info

Product

Resources

About