Heamonchus Contortusinfection in Sheep and Goats: alterations in haematological, biochemical, immunological, trace element and oxidative stress markers

Abstract

Haemonchus contortus (H. contortus) is one of the most pathogenic gastrointestinal nematodes of sheep and goats. The present study was aimed to investigate the impact of H.contortus natural infection in sheep and goats. The haematological, biochemical, immunological and oxidative stress markers were estimated. Blood samples were collected from clinically infected animals for analysis. Abomasum examination was performed after slaughter the animals to confirm the presence of H.contortus adult worm. Parasitologically, H.contortus worms were detected and counted in the abomasum of infected animals. Haematological findings revealed that naturally infected sheep and goats exhibited microcytic hypochromic anaemia, leukopenia, lymphopenia and neutropenia with eosinophilia. H.contortus infection-induced hypoproteinemia, hypoalbuminemia, and hypoglobulinemia. Also, it markedly lowered the serum IgG&IgM and elevated serum IgE levels. Serum concentration of superoxide dismutase (SOD) was reduced, whereas lipid peroxidation (MDA) levels were elevated. However, serum levels of iron (Fe), zinc (Zn) and copper (Cu) were markedly lowered and the total iron-binding capacity (TIBC) was elevated. Finally, this work clears that H.contortus infection in sheep and goats induced alterations in haematological, biochemical and immune marker, with stimulation of oxidative stress, these results may be good and helpful for detect and diagnose of H.contortus infection in sheep and goats.

Effects of Medicinal Plants and Organic Selenium against Ovine Haemonchosis

“…A similar increase in MCV was reported for Creole goats infected with H. contortus fed four diets with different contents of protein and energy [ 44 ]. Clinical signs of haemonchosis such as anemia have been correlated with clinicopathological and parasitological findings and are helpful for detecting and diagnosing H. contortus infections in sheep and goats [ 47 ].…”

Anaplasma phagocytophilum and Anaplasma ovis–Emerging Pathogens in the German Sheep Population

“…DNA or of antibodies against Anaplasma species. The analysis was hampered by the presence of selenium deficiency and endoparasitism, and both diseases influence hematological and biochemical values [ 42 , 43 , 44 ]. Nevertheless, it is still worth discussing the major findings.…”

“…Selenium deficiency and/or endoparasitism were diagnosed in all flocks and might concur to the ill thriftiness [ 82 , 83 ]. Both diseases are regularly diagnosed in sheep flocks [ 83 , 84 , 85 ] and have an impact on hematological and biochemical values [ 42 , 43 , 44 ]. Reticulocytes were not determined, and thrombocytopenia was not confirmed by examination of blood smears due to operational reasons.…”

Effectiveness Comparison Between Young Leaf Extracts Acacia nilotica with Desmanthus virgatus Against Vermicidal Potency of Haemonchus contortus In-vitro

“…Ternak yang terinfeksi H. contortus dapat menunjukkan gejala klinis, diantaranya: penurunan produksi dan reproduksi, konjungtiva pucat atau anemia. Domba dan kambing yang terinfeksi secara alami menunjukkan anemia hipokromik mikrositik, eosinophilia, leukopenia, limfopenia, dan neu tro penia (Alam et al, 2020). Gangguan hematologi ini berpengaruh terhadap penurunan kondisi fisiologinya sehingga ternak tersebut lebih peka terhadap infeksi mikroorganisme yang lain.…”