<i>Haemaphysalis longicornis</i>Ticks as Reservoir and Vector of Severe Fever with Thrombocytopenia Syndrome Virus in China

Luo, Li; Zhao, Li; Wen, Hong Ling; Zhang, Zhen Tang; Liu, Jian Wei; Fang, Li Zhu; Xue, Zai Feng; Dong, Qiang; Zhang, Xiao Shuang; Ding, Shu Jun; Lei, Xiao Ying; Yu, Xue Jie

doi:10.3201/eid2110.150126

Cited by 273 publications

(205 citation statements)

References 18 publications

(27 reference statements)

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“…Finally, ticks can acquire the virus by feeding on blood of the SFTSV-infected host animals and transstadially and transovarially transmit it to other developmental stages of ticks. SFTSV infected ticks can transmit the virus to host animals during feeding [24, 25]. The other identified risk factor of weeds and shrubs present around the house is consistent with the fact that Haemaphysalis longicornis is known as a bush or scrub tick that is free-living in the environment waiting a suitable host (e.g.…”

Section: Discussionmentioning

confidence: 68%

Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study

Wang

et al. 2016

PLoS ONE

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BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus. Previous studies about risk factors for SFTSV infection have yielded inconsistent results, and behavior factors have not been fully clarified.MethodsA community-based, 1:4 matched case-control study was carried out to investigate the risk factors for SFTS in China. Cases of SFTS were defined as laboratory-confirmed cases that tested positive for real-time PCR (RT-PCR) for severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) or positive for IgM antibodies against SFTSV. Controls of four neighborhood subjects were selected by matching for sex, age, and occupation. Standardized questionnaires were used to collect detailed information about their demographics and risk factors for SFTSV infection.ResultsA total of 334 subjects participated in the study including 69 cases and 265 controls. The median age of the cases was 59.5 years, 55.1% were male, and 87.0% were farmers. No differences in demographics were observed between cases and controls. In the final multivariate analysis, tick bites two weeks prior to disease onset (OR = 8.04, 95%CI 3.34–19.37) and the presence of weeds and shrubs around the house (OR = 3.46, 95%CI 0.96–12.46) were found to be risk factors for SFTSV infection; taking preventative measures during outdoor activities (OR = 0.12, 95%CI 0.01–1.01) provided greater protection from SFTSV infection.ConclusionsOur results further confirm that SFTSV is transmitted by tick bites and prove that preventative measures that reduce exposure to ticks can prevent SFTSV infection. More efforts should be directed toward health education and behavior change for high-risk populations, especially outdoor workers, in SFTS endemic areas.

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Section: Discussionmentioning

confidence: 68%

Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study

Wang

et al. 2016

PLoS ONE

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“…Previous studies have suggested that Haemaphysalis longicornis and Rhipicephalus microplus ticks are the most likely vectors of SFTSV transmission to humans ( 10 , 11 ). H. longicornis ticks are widespread in South Korea and their density is high during May–August, when temperatures are usually warm ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Severe Fever with Thrombocytopenia Syndrome in Patients Suspected of Having Scrub Typhus

Wi¹,

Woo²,

Park³

et al. 2016

Emerg. Infect. Dis.

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“…SFTS is caused by SFTS virus (SFTSV), a tickborne bunyavirus that is transmitted through tick bites ( 1 , 3 , 4 ) and person to person by contact with patient blood ( 5 , 6 ). Clinically, SFTS is characterized by a sudden onset of fever, thrombocytopenia, hemorrhagic tendency, gastrointestinal symptoms, and multiple organ dysfunction and a high case-fatality rate of 12%–30% ( 1 ).…”

mentioning

confidence: 99%

Neutralizing Antibodies to Severe Fever with Thrombocytopenia Syndrome Virus 4 Years after Hospitalization, China

Huang¹,

Zhao²,

Wen³

et al. 2016

Emerg. Infect. Dis.

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Haemaphysalis longicornisTicks as Reservoir and Vector of Severe Fever with Thrombocytopenia Syndrome Virus in China

Abstract: Transstadial and transovarial virus transmission occur among ticks, and transmission to mice can occur through a tick bite.

Cited by 273 publications

References 18 publications

Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study

Risk Factors for Bunyavirus-Associated Severe Fever with Thrombocytopenia Syndrome: A Community-Based Case-Control Study

Severe Fever with Thrombocytopenia Syndrome in Patients Suspected of Having Scrub Typhus

Neutralizing Antibodies to Severe Fever with Thrombocytopenia Syndrome Virus 4 Years after Hospitalization, China

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