Neutralizing Antibodies to Severe Fever with Thrombocytopenia Syndrome Virus 4 Years after Hospitalization, China

Huang, Yu; Zhao, Li; Wen, Hong Ling; Yang, Yi; Yu, Hao; Yu, Xue Jie

doi:10.3201/eid2211.160414

Cited by 23 publications

(28 citation statements)

References 14 publications

(16 reference statements)

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“…The presence of antibody to SFTSV in an individual is considered as evidence of past SFTSV infection. In the cases of recovery from SFTS infection, antibody possessing neutral activity against SFTSV has been reported even 4 years after the viral infection . In the present study, no antibody‐positive samples indicating a history of SFTSV infection were found among 3990 donations obtained from the Chugoku‐Shikoku district in Japan.…”

Section: Discussioncontrasting

confidence: 45%

Investigation of antibody to severe fever with thrombocytopenia syndrome virus (SFTSV) in blood samples donated in a SFTS‐endemic area in Japan

et al. 2018

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The risk of transfusion-transmitted infection (TTI) for severe fever with thrombocytopenia syndrome virus (SFTSV) is a concern because person-to-person transmission resulting from contact with SFTSV-contaminated blood has been reported. To obtain information regarding the risk of TTI-SFTSV, antibody testing was performed for blood samples donated in an severe fever with thrombocytopenia syndrome-endemic area in Japan. No antibody-positive samples were detected among 3990 samples. This finding suggested that there were few cases of SFTSV infection among donors and that the risk of TTI-SFTSV was also estimated low in Japan.

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Section: Discussioncontrasting

confidence: 45%

Investigation of antibody to severe fever with thrombocytopenia syndrome virus (SFTSV) in blood samples donated in a SFTS‐endemic area in Japan

et al. 2018

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“…Studies have shown that neutralizing antibodies against SFTSV surface glycoprotein (glycoprotein N, Gn) are highly associated with patient survival (11)(12)(13). Our previous study in a patient cohort demonstrated that the presence of serum anti-Gn antibodies was correlated with survival, while the mortality of SFTS patients without serum anti-Gn antibodies was as high as 66.7% (14).…”

Section: Introductionmentioning

confidence: 90%

A single-domain antibody inhibits SFTSV and mitigates virus-induced pathogenesis in vivo

Wu¹,

Li²,

Huang³

et al. 2020

JCI Insight

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“…Recent studies have shown that 100% of SFTS confirmed cases produce neutralizing antibodies to SFTSV and can last for four years with a decrease in titers 17 . We also performed a follow-up study of eight people with neutralizing antibodies in 2014 and 2017.…”

Section: Discussionmentioning

confidence: 99%

Neutralizing antibodies to Severe Fever with Thrombocytopenia Syndrome Virus in general population, Shandong Province, China

Shao

et al. 2018

Sci Rep

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by SFTS virus (SFTSV) in East Asia. The research on seroprevalence of SFTSV in healthy people and risk factors had been detailed. However, the levels of neutralizing antibodies against SFTSV in general population were currently unclear. In the present study, we tested 1375 healthy persons from Penglai County, eastern China, for SFTSV neutralizing antibodies; 0.58% (8/1,375) was positive and the positive rates were not significantly different among people at different age groups, occupations and genders. Besides, a follow-up study was conducted and the titer of neutralizing antibodies decreased over time in all eight people but one, and the neutralizing antibodies of five lasted for the entire study period of seven years. Our results suggesting that subclinical infection or a relatively mild form of SFTS illness is occurring in this population, but a small percentage of sera have neutralizing capacity to SFTSV. Hence, most people are just susceptible to SFTSV infection.

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Neutralizing Antibodies to Severe Fever with Thrombocytopenia Syndrome Virus 4 Years after Hospitalization, China

Cited by 23 publications

References 14 publications

Investigation of antibody to severe fever with thrombocytopenia syndrome virus (SFTSV) in blood samples donated in a SFTS‐endemic area in Japan

Investigation of antibody to severe fever with thrombocytopenia syndrome virus (SFTSV) in blood samples donated in a SFTS‐endemic area in Japan

A single-domain antibody inhibits SFTSV and mitigates virus-induced pathogenesis in vivo

Neutralizing antibodies to Severe Fever with Thrombocytopenia Syndrome Virus in general population, Shandong Province, China

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