<i>Gynura procumbens</i> Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil

Nazri, Khuzaidatul Azidah Ahmad; Fauzi, Norsyahida Mohd; Buang, Fhataheya; Saad, Qodriyah Haji Mohd; Husain, Khairana; Jantan, Ibrahim; Jubri, Zakiah

doi:10.1155/2019/7246756

Cited by 16 publications

(13 citation statements)

References 58 publications

(59 reference statements)

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“…In the present study, we have evaluated the analgesic, anti-inflammatory, anticoagulant, and antidepressant activities of saffron ethanolic extracts in mice. The selection of 80% ethanol and/or ethanolic extracts was chosen for the study due to their efficiency against cancer [ 43 , 44 ], blood pressure [ 45 , 46 ], inflammation [ 47 ], and nociception [ 48 , 49 ]. None of the orally administered saffron extracts (800 mg/kg) caused any mortality or prominent behavioral abnormalities in mice during the 7-days acute toxicity study.…”

Section: Discussionmentioning

confidence: 99%

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan

Muhamad

Ismail

et al. 2020

Plants

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Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate, carrageenan-induced paw edema, capillary tube and forced swim test, respectively in mice. The results indicated that among all the extracts, stigma ethanolic extract (SEE) represented maximum latency activity (72.85%) and edema inhibition (77.33%) followed by petal ethanolic extract (PEE) with latency activity and edema inhibition of 64.06 and 70.50%, respectively. Corm ethanolic extract (CEE) and leaf ethanolic extract (LEE) displayed mild analgesic activity of 22.40% and 29.07%, respectively. Additionally, LEE (53.29%) and CEE (47.47%) exhibited mild to moderate response against inflammation. The coagulation time of SEE (101.66 s) was almost equivalent to the standard drug, aspirin (101.66 s), suggesting a strong anticoagulant effect followed by PEE (86.5 s). LEE (66.83 s) represented moderate inhibitory effect on coagulation activity while CEE (42.83 s) showed neutral effect. Additionally, PEE and SEE also expressed itself as potential antidepressants with immobility time ≤76.66 s, while CEE (96.50 s) and LEE (106.83 s) indicated moderate to mild antidepressant efficacy. Based on the in vivo activities, saffron extract, particularly SEE and PEE, can be used as a potential nutraceutical and therapeutic agent due to its significant pharmacological activities.

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Section: Discussionmentioning

confidence: 99%

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Khan

Muhamad

Ismail

et al. 2020

Plants

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“…The biomarkers modulation and metabolomics indicators for DM have their roots in the genetic regime, as catalase gene regulation is known to improve the antioxidant catalase enzyme due to the functional role of phytochemicals. 40 The current investigation explored the antidiabetic and hypolipidemic aspects of C. circinalis leaf extract, which might be of great significance. The findings confirmed the ethnopharmacological use of C. circinalis to treat hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

Polyphenol fingerprinting and hypoglycemic attributes of optimized Cycas circinalis leaf extracts

et al. 2020

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BACKGROUND Cycas circinalis leaves are used to treat diabetes mellitus in local medicinal systems without any scientifically proved information on their medicinal potential and phytochemicals. In this study, the total phenolic contents, total flavonoid contents, and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging and inhibitory effects on α‐glucosidase and α‐amylase were determined for optimized hydroethanolic leaf extracts. Secondary metabolites were identified using ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry (UHPLC–QTOF‐MS/MS). In vivo studies on diabetic albino mice were also carried out to evaluate the impact of the most active extract on their blood glucose levels. RESULTS The 60% ethanolic extract showed the highest extract yield (209.70 ± 0.20 g kg−1) and total phenolic (154.24 ± 3.28 mg gallic acid equivalent) and flavonoid (78.52 ± 1.65 mg rutin equivalent per gram dried extract) contents and exhibited the maximum DPPH scavenging activity (IC50 = 59.68 ± 2.82 μg mL−1). The IC50 values for inhibition of α‐glucosidase (58.42 ± 2.22 μg mL−1) and α‐amylase (74.11 ± 1.70 μg mL−1) were also significant for the 60% ethanolic extract. The untargeted UHPLC–QTOF‐MS/MS‐based metabolite profiling confirmed the presence of iridoid glucoside, gibberellin A4, O‐β‐d‐glucosyl‐4‐hydroxy‐cinnamate, 3‐methoxy‐2‐phyenyl‐4H‐furo[2,3‐h]chromen‐4‐one, kaempferol, withaferin A, amentoflavone, quercitin‐3‐O‐(6″‐malonyl glucoside), ellagic acid, and gallic acid. Plant extract at a dose of 500 mg kg−1 body weight reduced the blood glucose level by a considerable extent and also improved the lipid profile of diabetic mice after a 28‐day trial. CONCLUSION The findings revealed the medicinal potential of C. circinalis leaves to treat diabetes mellitus and provided the nutraceutical leads for functional food development. © 2020 Society of Chemical Industry

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“…The major compounds present in the extract have been identified previously by us, by using a validated HPLC method and LC-MS/MS analysis (Ahmad Nazri et al. 2019 ). The HPLC chromatogram and LC-MS/MS data are shown in Supplementary 1 (S1) .…”

Section: Methodsmentioning

confidence: 99%

“…GP or ATV was administered in a maximum volume of 1 mL to each rat accordingly (Ahmad Nazri et al. 2019 ). Toxicity effects from GP and ATV supplementation were verified by liver function test.…”

Section: Methodsmentioning

confidence: 99%

Gynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet

Nazri

Saad

Fauzi

et al. 2021

Pharmaceutical Biology

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Context Gynura procumbens (Lour.) Merr. (Asteraceae) has been reported to have various pharmacological activities including anti-inflammatory effects. Objective This study sought to determine whether Gynura procumbens (GP) could improve vascular reactivity by suppressing inflammation in postmenopausal rats fed with five-times heated palm oil (5HPO) diet. Materials and methods Forty-eight female Sprague-Dawley rats were randomly divided into sham [non-ovariectomized; grouped as control, GP extracts (250 and 500 mg/kg), atorvastatin (ATV, 10 mg/kg)] and postmenopausal (PM) groups [ovariectomized rats fed with 5HPO; grouped as PM, GP extracts (250 and 500 mg/kg) and ATV (10 mg/kg)]. Each group ( n = 6) was either supplemented with GP extract or ATV orally once daily for 6 months. Results In comparison with the untreated PM group, 250 and 500 mg/kg GP supplementation to PM groups reduced the systolic blood pressure (103 ± 2.7, 86 ± 2.4 vs. 156 ± 7.83 mmHg, p < 0.05), intima-media thickness (101.28 ± 3.4, 93.91 ± 2.93 vs. 143.78 ± 3.31 µM), vasoconstriction percentage induced by phenylephrine (102.5%, 88.3%, vs. 51.8%), sICAM-1 (0.49, 0.26 vs. 0.56 pg/mL) and sVCAM-1 (0.39, 0.25 vs. 0.45 pg/mL). GP extract supplementation increased vasorelaxation percentage induced by acetylcholine (78.4% vs. 47.3%) and sodium nitroprusside (84.2% vs. 53.7%), increased changes in plasma nitric oxide level (1.25%, 1.31% vs. 1.9%), and suppressed the elevation of TNF-α (0.39 vs. 1.02 pg/mL), IL-6 (0.43 vs. 0.77 pg/mL) and CRP (0.29 vs. 0.69 ng/mL) in the PM groups. Conclusions GP extract might improve vascular dysfunction by suppressing the inflammatory response, consequently preventing blood pressure elevation.

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Gynura procumbens Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil

Cited by 16 publications

References 58 publications

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice

Polyphenol fingerprinting and hypoglycemic attributes of optimized Cycas circinalis leaf extracts

Gynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet

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