GSTT1,GSTM1andCYP2E1genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

Colombo, Jucimara; Rossit, Andreéa Regina Baptista; Caetano, Alaor; Borim, Aldenis Albaneze; Wornrath, Durval; Silva, Ana Elizabete

doi:10.3748/wjg.v10.i9.1240

Cited by 41 publications

(25 citation statements)

References 53 publications

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“…GSTM1, GSTT1 and GSTP1 genes of the GST super gene family exhibit polymorphisms, which are associated with reduced enzyme activity (Pemble et al, 1994;Hayes et al, 1995;Ali-Osman et al, 1997). The results on the association of GST polymorphisms with gastric cancer are contradictory by previous studies (Colombo et al, 2004;Tamer et al, 2005You et al, 2005Martinez et a;. The difference might be due to ethnic variations, or differences in expression of GST genes.…”

Section: Introductionmentioning

confidence: 88%

Glulathione-S-transferases Gene Polymorphism in Prediction of Gastric Cancer Risk by Smoking and Helicobacter Pylori Infection Status

Chen¹,

Huang²,

Duan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aim: To evaluate the association of glutathione S-transferases gene polymorphisms with the risk of gastric cancer, with reference to smoking and Helicobacter pylori infection. Methods: We conducted a 1:1 matched casecontrol study with 410 gastric cancer cases and 410 cancer-free controls. Polymorphisms of GSTM1, GSTT1 and GSTP1 were determined using PCR-CTPP. Results: The GSTM1 and GSTT1 null genotypes were significantly associated with the risk of gastric cancer after adjusting for potential confounding factors (OR=1.68, 95% CI=1.32-2.23 for null GSTM1, OR=1.73; 95% CI=1.24-2.13 for null GSTT1). The combination of null GSTM1 and null GSTT1 conferred an elevated risk (OR=2.54, 95% CI=1.55-3.39). However, no association was found for GSTP1 polymorphism The smoking modified the association of GSTM1 and GSTT1 null genotypes with the risk of gastric cancer. Conclusion: GSTM1 and GSTT1 null genotypes are associated with increased risk of gastric cancer, and smoking modifies the association.

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Section: Introductionmentioning

confidence: 88%

Glulathione-S-transferases Gene Polymorphism in Prediction of Gastric Cancer Risk by Smoking and Helicobacter Pylori Infection Status

Chen¹,

Huang²,

Duan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Deletion of GSTT1 was found not to be associated with gastric cancer risk in several studies in a variety of populations (17,(20)(21)(22)(23)(24)(25)(26)(27). One study in Poland found a significant increase in risk for null GSTT1 limited to cases with age <50 years (28); another study in China reported a significant OR of 2.5 for GSTT1 deletion (29).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

Agudo¹,

Sala

Pera³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C>A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus À3859G>A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis. (Cancer Epidemiol Biomarkers Prev

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“…Homozygous deletions of these genes, referred to as GSTM1 null and GSTT1 null, respectively, result in lack of enzyme activity. Null mutations of these genes have been associated with increased risk for a number of cancers in some studies (6-11), but not in others (12)(13)(14)(15)(16). Two studies have reported modest associations between nasopharyngeal carcinoma and GSTM1 and/or GSTT1 deletions; however, these studies were quite small, with less than 100 nasopharyngeal carcinoma cases (17,18).…”

Section: Introductionmentioning

confidence: 96%

GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese

Guo

O’Brien

Zeng

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Southern China is a major nasopharyngeal carcinomaendemic region. Environmental factors and genetic susceptibility contribute to nasopharyngeal carcinoma development in this area. Polymorphic deletions of GSTM1 and GSTT1 genes involved in the detoxification of potentially carcinogenic agents may be a risk factor for nasopharyngeal carcinoma. To investigate the roles of genetic variations of GSTM1 and GSTT1 in nasopharyngeal carcinoma susceptibility in the Chinese population, we conducted a case-control study of 350 nasopharyngeal carcinoma cases and 622 controls. GSTM1 and GSTT1 deletion variants were genotyped by multiplex PCR assays. Logistic regression analysis was used to estimate odds ratios and 95% confidence intervals (95% CI). No significant association was observed for either GSTM1-or GSTT1-null genotype independently in the contribution to nasopharyngeal carcinoma risk. To explore possible joint effects of the GSTM1-and GSTT1-null polymorphisms with each other and with other risk factors for nasopharyngeal carcinoma, we examined the association between each combined genotype and the risk for nasopharyngeal carcinoma stratified by gender and EBV replication status. We found that individuals who carried GSTM1/ GSTT1 -double null genotype had a higher risk for nasopharyngeal carcinoma in the male population (odds ratio, 1.76; 95% confidence interval, 1.04-2.97; P = 0.03); however, this was not significant after correction for multiple comparisons. No statistical difference was found between cases and controls in females and the subpopulation positive for immunoglobulin A antibodies to EBV capsid antigen for combined genotypes. Our results suggest that the GSTM1/GSTT1 -double null genotype may be a risk factor for nasopharyngeal carcinoma among males in southern China, but this result warrants confirmation in other studies. (Cancer Epidemiol Biomarkers Prev 2008;17(7):1760 -3)

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GSTT1,GSTM1andCYP2E1genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

Cited by 41 publications

References 53 publications

Glulathione-S-transferases Gene Polymorphism in Prediction of Gastric Cancer Risk by Smoking and Helicobacter Pylori Infection Status

Glulathione-S-transferases Gene Polymorphism in Prediction of Gastric Cancer Risk by Smoking and Helicobacter Pylori Infection Status

Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

GSTM1 and GSTT1 Gene Deletions and the Risk for Nasopharyngeal Carcinoma in Han Chinese

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