Ganodermataceae: Natural Products and Their Related Pharmacological Functions

Abstract

The objective of this paper is to review the natural products and the pharmacological functions of Ganodermataceae family. Presently, studies on the bioactive components of Lingzhi are focused on polysaccharides and triterpenes/triterpenoids compounds. New Ganoderma polysaccharides, including their molecular weights, glycosyl residue compositions, glycosyl linkage and branches, are summarized in this paper. Also presented are new types of triterpenes and their characteristics from Lingzhi. Taking Ganoderma lucidum as an example, we reviewed its pharmacological functions in anti-tumor and immune-modulating activities for treating hypoglycemosis, hepatoprotection, and the effect on blood vessel system. Based on the advances in Lingzhi research in the past few decades, both G. lucidum and G. sinense are considered as the representative species of medicinal mushroom Lingzhi in China. Until 2001, G. tsugae was only advised to be used as the materials of the health products. The biologically-active components related to pharmacological functions of these three species were studied more than other Ganodermataceae family species; however, which have been used in less modern folk medicine.

Antioxidative and Antiinflammatory Activities of the Chloroform Extract of Ganoderma lucidum Found in South India

“…The major chemical components of G. lucidum are known to be polysaccharides and triterpenoids [35]. Thus triterpenoids of chloroform extract might be responsible for the antioxidant and inflammatory activities [36]. Kim et al (1999) [37] identified ganoderic acid A, B, G, and H, the triterpene component of commercial strain of G. lucidum, for its antiinflammatory activity.…”

Nutritional and medicinal importance of mushrooms

“…Russell and Paterson (2006) observed that triterpenoides are the main chemical compounds in G. lucidium. Camptothecin is responsible for antioxidant properties in G. lucidum (Zhou et al, 2007).…”

Molecular docking studies on rocaglamide, a traditional Chinese medicine for periodontitis

“…Thus, the development of strategies is based on these two factors. Compounds of natural origin are invaluable in novel drug discovery, and many natural compounds have been reported to have dual functions [17,20]. The present study was focused on a compound with antimicrobial and anti-inflammatory properties.…”