<i>Fatty liver index</i> and <i>hepatic steatosis index for prediction of</i> non‐alcoholic fatty liver disease in type 1 diabetes

Sviklāne, Laura; Olmane, Evija; Dzērve, Zane; Kupčs, Kārlis; Pīrāgs, Valdis; Sokolovska, Jeļizaveta

doi:10.1111/jgh.13814

Cited by 105 publications

(85 citation statements)

References 32 publications

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“…Suspected NAFLD was defined alternatively as hepatic steatosis index (HSI) > 36, fatty liver index (FLI) ≥ 60, either, or both. 3 NAFLD-associated advanced fibrosis was defined as BMI ≥ 25 kg/m 2 , ALT > 40 U/L (men), or > 30 U/L (women) and either AST-to-platelet ratio index (APRI) > 1, fibrosis-4 (FIB-4) index > 2.67, or NAFLD fibrosis score (NFS) > 0.676. 4 Cirrhosis was defined as APRI > 2 and either ALT > 40 U/L (men) or > 30 U/L (women), alkaline phosphatase > 113 U/L, or total bilirubin > 1.3 mg/dL, and NASH cirrhosis as cirrhosis plus either obesity, insulin resistance, or metabolic syndrome.…”

Section: Methodsmentioning

confidence: 99%

Trends in Prevalence of Nonalcoholic Fatty Liver Disease in US Adults with Prediabetes

Chaitoff

Rothberg

et al. 2019

J GEN INTERN MED

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In this population-based study, we found that between 44 and 62% of US adults with prediabetes had concurrent suspected NAFLD, equivalent to 27-38 million patients, and similar to the numbers of prediabetic patients with hypertension or dyslipidemia. Our study appears to be the first to establish a populationbased estimate of suspected NAFLD prevalence trends in prediabetic US adults. In Germany, the prevalence of NAFLD measured by localized proton magnetic resonance spectroscopy was 45-78%, 5 while in Korea, it was 60% based on ultrasound. 6 The prevalence of prediabetes in the USA has been increasing for two decades, reaching 34% in 2015. Although intensive lifestyle modification and metformin have been shown to reduce progression to diabetes by 27% and 18%, respectively, 1 it is not known whether these interventions can affect liver function and prevent NAFLD progression. It is also not known to what extent these interventions are being used in clinical practice. Our findings that at least 27 million US adults have

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Section: Methodsmentioning

confidence: 99%

Trends in Prevalence of Nonalcoholic Fatty Liver Disease in US Adults with Prediabetes

Chaitoff

Rothberg

et al. 2019

J GEN INTERN MED

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“…Compared to the heavy toll imposed on the liver by T2DM, epidemiological data on the burden of NAFLD imposed by T1DM (i.e., a disease that is characterized by an altered porto-systemic gradient of insulin and a lesser degree of insulin resistance compared to T2DM) appear to be more variable (summarized in Supplementary Table 2) [59][60][61][62][63][64][65][66][67] .…”

Section: T1dmmentioning

confidence: 99%

Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus

2017

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Nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus are common diseases that often coexist and might act synergistically to increase the risk of hepatic and extra-hepatic clinical outcomes. NAFLD affects up to 70-80% of patients with type 2 diabetes mellitus and up to 30-40% of adults with type 1 diabetes mellitus. The coexistence of NAFLD and diabetes mellitus increases the risk of developing not only the more severe forms of NAFLD but also chronic vascular complications of diabetes mellitus. Indeed, substantial evidence links NAFLD with an increased risk of developing cardiovascular disease and other cardiac and arrhythmic complications in patients with type 1 diabetes mellitus or type 2 diabetes mellitus. NAFLD is also associated with an increased risk of developing microvascular diabetic complications, especially chronic kidney disease. This Review focuses on the strong association between NAFLD and the risk of chronic vascular complications in patients with type 1 diabetes mellitus or type 2 diabetes mellitus, thereby promoting an increased awareness of the extra-hepatic implications of this increasingly prevalent and burdensome liver disease. We also discuss the putative underlying mechanisms by which NAFLD contributes to vascular diseases, as well as the emerging role of changes in the gut microbiota (dysbiosis) in the pathogenesis of NAFLD and associated vascular diseases.

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“…e Hepatic Steatosis Index (HSI) is a preliminary screening tool for NAFLD, which uses a formula based on BMI, ALT (IU/L), and AST (IU/L), and the presence or absence of diabetes as follows: HSI � 8 * (ALT/AST ratio) + BMI(+2, if T2DM; +2, if female). Additionally, NAFLD was defined as HSI above 36 [25].…”

Section: Calculation Of Hgi Hsi and Nfsmentioning

confidence: 99%

Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals

Zhu

et al. 2019

Canadian Journal of Gastroenterology and Hepatology

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Purpose. Limited studies have preliminarily identified a positive association between nonalcoholic fatty liver disease (NAFLD) and hemoglobin glycation index (HGI). However, this association has not been fully established. We aim to investigate the association between NAFLD and HGI in Chinese nondiabetic individuals and to construct a risk score based on HGI to predict a person’s risk of NAFLD. Methods. After strict exclusion criteria, 5,903 individuals were included in this retrospective cross-sectional study. We randomly selected 1,967 subjects in the enrollment to obtain an equation of linear regression, which was used to calculate predicted HbA1c and drive HGI. The other subjects were classified into four categories according to HGI level (≤−0.22, −0.21∼0.02, 0.03∼0.28, and ≥0.29). All subjects retrospectively reviewed the baseline characteristics, laboratory examinations, and abdominal ultrasonography. Results. The prevalence of NAFLD in this population was 20.7%, which increases along with the growth of HGI levels (P<0.001). Adjusted to multiple factors, this trend still remained significant (OR: 1.172 (95% CI, 1.074–1.279)). The combined NAFLD risk score based on HGI resulted in an area under the receiver operator characteristic curve (AUROC) of 0.85 provided sensitivity, specificity, positive predictive value, and a negative predictive value for NAFLD of 84.4%, 71.3%, 65.0%, and 88.0%, respectively. Conclusions. NAFLD is independently associated with HGI levels in Chinese nondiabetic individuals. And, NAFLD risk score may be used as one of the risk predictors of NAFLD in nondiabetic population.

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Fatty liver index and hepatic steatosis index for prediction of non‐alcoholic fatty liver disease in type 1 diabetes

Abstract: Key words fatty liver index, hepatic steatosis index, metabolic syndrome, non-alcoholic fatty liver disease, type 1 diabetes mellitus.Accepted for publication 27 April 2017.

Cited by 105 publications

References 32 publications

Trends in Prevalence of Nonalcoholic Fatty Liver Disease in US Adults with Prediabetes

Trends in Prevalence of Nonalcoholic Fatty Liver Disease in US Adults with Prediabetes

Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus

Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals

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