Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals

Hu, Di-Shuang; Zhu, S.-H.; Xu, Li; Chen, Qin-Fen; Cui, Lin; Fang, Daoquan; Wu, Jiansheng

doi:10.1155/2019/8748459

Cited by 12 publications

(14 citation statements)

References 38 publications

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“…8,9,11 And in non-diabetic individuals, subjects with high HGI have a higher prevalence of non-alcoholic fatty liver disease, carotid atherosclerosis. 30,31 This study found a higher prevalence of vitamin D deficiency in patients with high HGI, and the HGI levels were inversely correlated with vitamin D.…”

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confidence: 55%

The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

Li¹,

Wang²,

Jia³

et al. 2021

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Objective This study aimed to investigate the relationship between hemoglobin glycation variation index (HGI) and vitamin D in patients with type 2 diabetes mellitus (T2DM). Materials and Methods This is a cross-sectional study that recruited 347 patients with T2DM. The subjects were divided into no vitamin D deficiency group (25(OH)D ≥20 ng/mL) and vitamin D deficiency group (25(OH)D < 20 ng/mL). HGI was calculated as the difference between the measured and predicted values of HbA1c using the linear relationship between HbA1c level and fasting plasma glucose levels. All study participants were divided into high HGI and low HGI groups using the median of HGI as the boundary. At last, the subjects were divided into male group and female group, and these groups were further subdivided into vitamin D deficiency group and no vitamin D deficiency group. Results The levels of HGI were significantly higher in the vitamin D deficiency group compared with the no vitamin D deficiency group for all patients. The same was true for female patients but not for male patients. The prevalence of vitamin D deficiency in the high HGI group was higher than that in the low HGI group. The high HGI group had lower vitamin D levels compared to the low HGI group. Compared to the male group, the female group had lower vitamin D levels but higher HGI levels. A negative correlation existed between 25(OH) D and HGI in all subjects, as well as in the female-only subgroups. In the male-only subgroups, there was no correlation between them, and this positive correlation still existed after adjusting for other factors in multilinear regression analysis. Conclusion Our study showed for the first time that HGI is inversely associated with vitamin D in all patients with T2DM, and the correlation was also found in female patients, but not in male patients.

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confidence: 55%

The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

Li¹,

Wang²,

Jia³

et al. 2021

DMSO

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“… 32 HbA 1C may also vary due to biological differences among individuals, apart from hyperglycemic episodes. 33 Hyperglycemic episodes, in addition to the production of advanced glycation end-products also affect lipid metabolism and result in increased synthesis of TAGs that tend to deposit in various tissues of the body, including liver. TAG deposition in adipose tissue increases BMI, while in liver parenchyma it leads to fatty liver.…”

Section: Discussionmentioning

confidence: 99%

HbA1C as a Biomarker of Non-alcoholic Fatty Liver Disease: Comparison with Anthropometric Parameters

Masroor

Haque

2021

Journal of Clinical and Translational Hepatology

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Background and Aims Multiple non-invasive methods including radiological, anthropometric and biochemical markers have been reported with variable performance. The present study assessed glycosylated hemoglobin (HbA 1C ) as a biomarker to predict non-alcoholic fatty liver disease (NAFLD) and its severity, compared with body mass index (BMI), waist to hip ratio (WHR) and waist circumference (WC) Methods This case control study included 450 individuals, including 150 cases and 300 age- and gender-matched controls recruited from the Dow Radiology Institute on the basis of radiological findings of fatty infiltration on abdominal ultrasound through convenient sampling. BMI, WHR and WC were measured according to standard protocols. HbA 1C was determined by turbidimetric inhibition immunoassay Results Among the cases and controls, 66% and 32% had HbA 1C levels higher than 5.7% respectively. HbA 1C and BMI were significantly associated with NAFLD [crude odds ratio (cOR)=4.12, 2.88, 2.25 (overweight) and 4.32 (obese)]. WC was found to be significantly associated with NAFLD for both genders (cOR in males=5.50 and females=5.79, p <0.01). After adjustment for other parameters, HbA 1C and WC were found to be significantly associated with NAFLD (aOR=3.40, p <0.001) along with WC in males (aOR=2.91, p <0.05) and in females (aOR=4.28, p <0.05). A significant rise in severity of hepatic steatosis was noted with increases in HbA 1C , BMI and WC. HbA 1C possessed a positive predictive value of 76% for the study population [0.76, confidence interval (CI): 0.715-0.809], 70.6% for males (0.706, CI: 0.629-0.783) and 80% for females (0.80, CI: 0.741-0.858). Conclusions Higher than normal HbA 1C and WC measurements possess a more than 70% potential to predict NAFLD. It is the single risk factor that is strongly associated with NAFLD after adjustment for indices of body measurements. HbA 1C may be presented as a potential biomarker for NAFLD in examination with other anthropometric measures in the adult population.

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“…Similarly, Cohen et al, reported that patients with NAFLD exhibited an increased plasma concentration of TG and TC ( Cohen and Fisher, 2013 ). Moreover, Hu et al (2019) suggested that Glu levels are related to NAFLD. Hb has also been found to be associated with NAFLD ( Jiang et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Associations Among Methylene Tetrahydrofolate Reductase rs1801133 C677T Gene Variant, Food Groups, and Non-alcoholic Fatty Liver Disease Risk in the Chinese Population

Hao

Xiang

et al. 2021

Front. Genet.

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ObjectivesTo investigate the associations among the methylene tetrahydrofolate reductase rs1801133 C677T gene variant, food groups, and the risk of non-alcoholic fatty liver disease in the Chinese population.MethodsA study of gene polymorphism was conducted using the polymerase chain reaction method. A total of 4,049 adults participated in the study, and all underwent physical examination and genotyping. Participants filled out a dietary questionnaire to enable us to assess the frequency and quantity of food consumption.ResultsThe important variables identified as risk factors of non-alcoholic fatty liver disease were age, smoking, sex, body mass index, hyperlipidemia, diabetes, and methylene tetrahydrofolate reductase genotype (T – allele carriers). The homocysteine content was higher in the non-alcoholic fatty liver disease group than in the control group, and was higher in the T- allele than C- allele carriers. The homocysteine content was the highest in the T- allele carriers. Additionally, certain food groups such as milk and beans were associated with a lower risk of non-alcoholic fatty liver disease. Food groups such as meat, were associated with a higher risk of non-alcoholic fatty liver disease. Fresh fruit and vegetables, salted and smoked foods, desserts, cereals, fish, and eggs were not associated with the risk of non-alcoholic fatty liver disease. However, the influence of salted and smoked foods on non-alcoholic fatty liver disease was different in the C-allele and T-allele carriers of methylene tetrahydrofolate reductase (CT + TT vs. CC, OR = 1.196, P = 0.041 for 1–4 times food per week, OR = 1.580, P = 0.004 for 5–7 times per week). Similarly, salted and smoked foods were also a risk factor for the development of non-alcoholic steatohepatitis in patients with non-alcoholic fatty liver disease.ConclusionThis study found that the T-allele of the C677T variant of methylene tetrahydrofolate reductase was a risk factor for non-alcoholic fatty liver disease among Chinese people. These results can likely aid the development of novel approaches for managing non-alcoholic fatty liver disease risk.

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Association between Hemoglobin Glycation Index and NAFLD in Chinese Nondiabetic Individuals

Cited by 12 publications

References 38 publications

The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

HbA1C as a Biomarker of Non-alcoholic Fatty Liver Disease: Comparison with Anthropometric Parameters

Associations Among Methylene Tetrahydrofolate Reductase rs1801133 C677T Gene Variant, Food Groups, and Non-alcoholic Fatty Liver Disease Risk in the Chinese Population

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