Expression of Concern: Calcium plus vitamin D supplementation influences biomarkers of inflammation and oxidative stress in overweight and vitamin D‐deficient women with polycystic ovary syndrome: a randomized double‐blind placebo‐controlled clinical trial
Abstract:We found that calcium plus vitamin D cosupplementation for 8 weeks among overweight and vitamin D-deficient women with PCOS had beneficial effects on inflammatory factor and biomarkers of oxidative stress.
“…Subjects with PCOS are susceptible to some metabolic disorders and inflammation [12,13]. We found that taking CoQ10 for 12 weeks in subjects with PCOS downregulated LDLR expression, but did not affect Lp(a) expression.…”
Objective: This research was conducted to assess the effects of coenzyme Q10 (CoQ10) intake on gene expression related to insulin, lipid and inflammation in subjects with polycystic ovary syndrome (PCOS). Methods: This randomized double-blind, placebo-controlled trial was conducted on 40 subjects diagnosed with PCOS. Subjects were randomly allocated into two groups to intake either 100 mg CoQ10 (n ¼ 20) or placebo (n ¼ 20) per day for 12 weeks. Gene expression related to insulin, lipid and inflammation were quantified in blood samples of PCOS women with RT-PCR method.
“…Subjects with PCOS are susceptible to some metabolic disorders and inflammation [12,13]. We found that taking CoQ10 for 12 weeks in subjects with PCOS downregulated LDLR expression, but did not affect Lp(a) expression.…”
Objective: This research was conducted to assess the effects of coenzyme Q10 (CoQ10) intake on gene expression related to insulin, lipid and inflammation in subjects with polycystic ovary syndrome (PCOS). Methods: This randomized double-blind, placebo-controlled trial was conducted on 40 subjects diagnosed with PCOS. Subjects were randomly allocated into two groups to intake either 100 mg CoQ10 (n ¼ 20) or placebo (n ¼ 20) per day for 12 weeks. Gene expression related to insulin, lipid and inflammation were quantified in blood samples of PCOS women with RT-PCR method.
“…Vitamin D is a well-documented suppressor of oxidative stress [13][14][15]. Vitamin D-dependent activation (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), calcium (Ca), and phosphorus (P) levels were measured using an autoanalyzer (No.…”
“…Subjects with PCOS are susceptible to several metabolic complications, including insulin resistance and inflammation . We found that fish oil supplementation for 12 weeks to PCOS women upregulated gene expression of PPAR‐γ, but unchanged GLUT‐1 expression.…”
Overall, fish oil supplementation for 12 weeks to subjects with PCOS significantly improved gene expression of PPAR-γ, IL-1 and IL-8, but did not influence gene expression of LP(a), LDLR, GLUT-1, TNF-α and TGF-β.
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